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2016 Revision to the WHO classification of acute lymphoblastic leukemia

.48.9377 Moorman AV Robinson H Schwab C Richards SM Hancock J Mitchell CD et al Risk-directed treatment intensification significantly reduces the risk of relapse among children and adolescents with acute lymphoblastic leukemia and intrachromosomal amplification of chromosome 21: a comparison of the MRC ALL97/99 and UKALL2003 trials J Clin Oncol 2013 31 3389 96 7 Den Boer ML, van Slegtenhorst M, De Menezes RX, Cheok MH, Buijs-Gladdines JG, Peters ST, et al . A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

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Advances of studies on blood diseases and bone marrow microvessel

: Evidence favoring loss of marrow angiogenesis inhibitory activity with disease progression. Blood 2004;104:1159-65. 4. Norén-Nyström U, Heyman M, Frisk P, Golovleva I, Sundström C, Porwit A, et al. Vascular density in childhood acute lymphoblastic leukaemia correlates to biological factors and outcome. Br J Haematol 2009;146:521-30. 5. Antic D, Jovanovic MP, Fekete MD, Cokic V. Assessment of bone marrow microvessel density in chronic lymphocytic leukemia. Appl Immunohistochem Mol Morphol 2010;18:353-6. 6. Matuszewski L

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Confounding Factors of the Diabetes - Metformin - Cancer Relationship

associated with poor survival in colorectal cancer patients. PLoS One 7: e38953, 2012. 37. Han L, Ma Q, Li J et al. High glucose promotes pancreatic cancer cell proliferation via the induction of EGF expression and transactivation of EGFR. PLoS One 6: e27074, 2011. 38. Pan J, Chen C, Jin Y et al. Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells. Cell Cycle 11: 2314-2326, 2012. 39. Gallagher EJ, LeRoith D. Diabetes, cancer, and metformin: connections of metabolism and

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