energy level, radio waves are emitted. These discoveries were awarded the Nobel Prize in Physics in 1952 (jointly to Felix Bloch and Edward Mills Purcell “for their development of new methods for nuclear magnetic precision measurements and discoveries in connection therewith”). During the following decades, magnetic resonance was used mainly for studies of the chemical structure of substances. In the beginning of the 1970s, Paul C. Lauterbur and Sir Peter Mansfield made pioneering contributions which later led to the applications of magnetic resonance in medical
93. Ogawa T, Japan Neurotrauma Databank C. [Current clinical trends in brain trauma--Japan Neurotrauma Databank]. Brain Nerve. 2010;62(1):13-24.
94. Yokota H, Naoe Y, Nakabayashi M, Unemoto K, Kushimoto S, Kurokawa A, et al. Cerebral endothelial injury in severe head injury: the significance of measurements of serum thrombomodulin and the von Willebrand factor. J Neurotrauma. 2002;19(9):1007-15.
95. Yokota H, Yamamoto Y, Naoe Y, Fuse A, Sato H, Unemoto K, et al. Measurements of cortical cellular pH by intracranial tonometer in severe
Pablo Ajler, Alvaro Campero, Federico Landriel, Ezequiel Goldschmidt, Santiago Hem and Antonio Carrizo
. Decisions regarding adjuvant pharmacological or radiation therapy when laboratory or clinical abnormalities persisted were made following current practice guidelines by the endocrinologist monitoring the patient.
Evaluation and follow-up
Following discharge, patients were evaluated subsequently at months 3 and 6 after surgery. The first evaluation was used to define cure and included clinical assessment as well as random IGF-1 and GH level measurements following OGTT. A new MRI scan was obtained at this time. Biochemical control was defined as normal IGF-1