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Comparison of Four Methods for Corneal Thickness Measurement

References 1. Barkana Y, Gerber Y, Elbaz U, Schwartz S, Ken- Dror G, Avni I, et al. Central corneal thickness measurement with the Pentacam Scheimpflug system, optical low-coherence reflectometry pachymeter, and ultrasound pachymetry. J Cataract Refract Surg. 2005;3 (9): 729-35. 2. Doughty MJ, Zaman ML. Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol. 2000;44(5):367-408. 3. Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ

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Measurement and Comparison of Costs of Hypertensive Patients Aged 40-89 Years Treated with Lisinopril and Perindopril

Summary

A cross-sectional study was carried out in 2016 in the research project No 4/2016. We selected 98 patients aged 40-89 and diagnosed with hypertension. The patients were admitted to Cardiology Clinic One of the University Hospital in Pleven. The study aimed to measure and compare direct and indirect costs of hypertensive patients aged 40-89 years, who were treated with lisinopril and perindopril. We estimated the total and average costs of 50 (51.0%) patients treated with lisinopril and 48 (49.0%) treated with perindopril. Males were 46.4%, and the mean age of the sample was 65.9.0±11.2 years. Data were processed by Statistical Package for Social Science version 19.0 (SPSS.v.19.0). Total costs exceeded amount reimbursed for the clinical path (BGN 420.00) in 64.6% of the patients treated with perindopril and 48.0% of the patients treated with lisinopril. We found that treatment costs within 6-months after discharge were BGN 673.82 in patients treated with lisinopril, as compared to BGN 171.92 reimbursed by the National Health Insurance Fund (NHIF), and BGN 781.18 for those treated with perindopril, compared to BGN 216.33 reimbursed by NHIF. The NHIF reimbursement rate for antihypertensive treatment is insufficient to cover all direct costs. Increased hospital costs and out-of-pocket payments present a significant restriction on access to treatment for arterial hypertension.

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Assessment of the Impact of Oxidative Stress on Frozen Seminal Plasma in Fertile and Infertile Men by Examining the Total Antioxidant Capacity

Abstract

The aim of the study was to explore the impact of oxidative stress on frozen seminal plasma in fertile and infertile men by examining the total antioxidant capacity. Patients: Infertile patients from male infertility clinic with various diagnoses and fertile men. Design: Seminal plasma from proven fertile men [n=50] and infertile patients [n=50] were examined for total antioxidant capacity (TAC) level, semen parameters such as morphology, motility and concentration, and DNA integrity test. Interventions: Seminal plasma TAC measurement by luminometric assay using the TAC assay kit, semen analysis parameters, DNA integrity test. Fertile men showed higher TAC values (median and SD): 1201µM (SD±548), as compared with the infertile patients: 831μM (SD±343). The result from sperm morphology of fertile patients showed a mean percentage of 4.8 % (SD±1.68) whereas the percentage in the infertile group was 2.68% (SD ±1.68). The same group of samples, analyzed for DNA damage showed a mean of DFI 10.38% (SD±5.17%) in fertile men and a mean of DFI 17.22% (SD±7.22%) in infertile men. Total antioxidant capacity of the seminal plasma as measured by the luminоmetric assay is a reliable and simple test for diagnosing and management of male infertility.

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Leptin and Gaba Interactions on Thermoregulation of Rats

Abstract

Leptin inhibits feeding, reduces body weight and increases thermogenesis. Experimental data suggest involvement of GABAergic mechanisms in the regulation of feeding behavior and energy balance. The present study was set to determine the effect of combinations from leptin, GABAB-agonist baclofen and GABAB-antagonist CGP35348 on thermoregulation of male Wistar rats, using in vivo and in vitro experiments. The substances used for in vivo experiments were administered intraperitoneally (i.p.). The measurement of the body temperature was done via thermistor probes (TX8) and monitored on multichannel recorder Iso-Thermex16. In vitro experiments were conducted on rat PO/AH neurons, recorded extracellulary by conventional electrophysiological equipment, using brain slice preparations. The separate intraperitoneal injection of leptin as well as GABAB-antagonist CGP35348 produced significant hyperthermia in rats while the GABAB-agonist baclofen caused a decrease in the core body temperature. The probable synergy between the hyperthermic effects of leptin and GABAB-antagonist did not occur. On the contrary, the effect of this combination was lower as compared to the result of the separate administration of GABAB-antagonist. When leptin was applied just prior to GABAB-agonist baclofen, neither of their separate effects appeared. In vivo effects determined correlated with in vitro changes of firing rate observed in PO/AH neurons. The data from this study provide a new point of view concerning the interactions of leptin and GABA on the level of thermoregulation. These results represent a step forward in understanding the complicated mechanisms involved in thermoregulation.

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Effects Of Glucose And Bilirubin On The Kinetic Jaffe's And The Enzymatic Methods For Serum Creatinine Assay

References 1. Crocke H, Shephard S MD, White HG. Evaluation of an enzymatic method for determining creatinine in plasma. J Clin Pathol. 1988;41(5):576-81. 2. Peake M, Whiting M. Measurement of serum creatinine - Current status and future goals. Clin Biochem Rev. 2006;27(4):173-84. 3. Panteghini M, IFCC Scientific Division. Enzymatic assays for creatinine: time for action. Clin Chem LabMed. 2008;46(4):567-72. 4. Chromy V, Rozkosna K, Sedla KP. Determination of serum creatinine by Jaffe method and how to calibrate to eliminatematrix

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Dry Age-Related Macular Degeneration – A New Approach In Optical Coherence Tomography Monitoring And Quantitative Assessment

;293(15):1841-5. 15. Loduca AL, Zhang C, Zelkha R, Shahidi M. Thickness Mapping of Retinal Layers by Spectral Domain Optical Coherence Tomography. Am J Ophthalmol. 2010;150(6);849-55. 16. Huang J, Liu X, Wu Z, Xiao H, Dustin L, Sadda S. Macular Thickness Measurements in Normal Eyes with Time Domain and Fourier Domain Optical Coherence Tomography. Retina. 2009;29(7):980-7. 17. Early Treatment Diabetic Retinopathy Study Design and Baseline Patient Characteristics. ETDRS Report Number 7. Ophthalmology. 1991;98(5 Suppl):741-56. 18. Chakravarthy U, Wong TY, Fletcher A

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Attitudes Of Regular Alcohol Drinking Adolescents To Intersubjective Relations And Everyday Life

urban youths. Am J Public Health. 2005;95(5):887-93. 7. Seth P, Sales JM, DiClemente RJ, Wingood GM, Rose E, Patel SN. Longitudinal examination of alcohol use: a predictor of risky sexual behavior and Trichomonas vaginalis among African-American female adolescents. Sex Transm Dis. 2011;38(2):96-101. 8. Eysenck HJ, Eysenck SBG. Manual of the Eysenck Personality Questionnaire. London: Hodder and Stoughton; 1975. 9. Eysenck SBG, Eysenck HJ. The measurement of psychoticism: a study of factor stability and reliability. Br J Soc Clin Psychol. 1968

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Original Article. Matrix Metalloproteinase Mmp-2 and Mmp-9 Activities in Seminal Plasma

cytometric measurement of sperm nuclear DNAfragmentation in infertile men with normal standard sperm parameters. J Mens Health. 2009;6(1):50-5. 13. Bungum M. Sperm DNAintegrity assessment:anew tool in diagnosis and treatment of fertility. Obstet Gynecol Int. 2012;2012:1-6. 14. Nikolettos N, Kupker W, Demirel C, Schopper B, Blasig C, Sturm R, et al. Fertilization potential of spermatozoa with abnormal morphology. Hum Reprod. 1999;14(1):47-70. 15. Saengsoi W, Shia WY, Shyu C L,Wu JT,Warinrak C, Lee WM, et al. Detection of

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Alterations in Platelet Activity and Elastic Modulus of Healthy Subjects, Carriers of G20210A Polymorphism in the Prothrombin Gene

thromboembolism and their adult family members. Genet Med. 2011 ;13(l):67-76. doi: 10.1097/GIM.0b013e3181 fbe46f. PubMed PMID:21150787. 12. Franz CM, Puech P-H. Atomic Force Microscopy: A versatile tool for studying cell morphology, adhesion and mechanics. Cell Mol Bioeng. 2008;l(4):289-300. doi: 10.1007/s 12195-008-0037-3. 13. Lee IS, Marchant RE. Force measurements on platelet surfaces with high spatial resolution under physiological conditions. Colloids Surf B Biointerfaces. 2000;19(4):357-65. 14. Ortega JE, Barron

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Comparative Study Of The Protective Effect Of Aronia Melanocarpa Fruit Juice And Quercetin In A Model Of Paracetamol-Induced Hepatotoxicity In Rats

Sci Food Safety. 2012;11(5):471-89. 6. Valcheva-Kuzmanova S, Gadjeva V, Ivanova D, Belcheva A. Antioxidant activity of Aronia melanocarpa fruit juice in vitro. Acta Aliment. 2007;36(4):425-8. 7. Valcheva-Kuzmanova S, Blagović B, Valić S. Electron spin resonance measurement of radical scavenging activity of Aronia melanocarpa fruit juice. Pharmacog Mag. 2012;8(30):171-4. 8. Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem. 2003;51(2):502-9. 9. Wu XL

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