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compared to reference D, and D/U14bf and D/L11bf had 0.003– 0.006 ± 0.002–0.003 p-distance from D ( Table 4 ). Note that D/U1bf and D/U9bf harbored the same ompA polymorphisms that caused 0.000 p-distance against D ( Table 4 ). ompA variants were also observed in 1 clinical F and 2 Hs. Most polymorphisms were of different nt positions, and many encoded for amino acid changes and thus high dN/dS. Bidirectional sequencing indicated H/U20bf and H/ L23bf containing a substitution that caused a stop codon (W295). However, these ompA variants remained phylogenetically

count in HIV monoinfected, and patients coinfected with HIV and HBV or HCV currently on combination ART (n= 199) HBsAg - /anti-HCV - (n = 160) HBsAg/anti-HCV - (n = 23) HBsAg - /anti-HCV + (n = 16) P P Median Range Median Range Median Range AST(U/L) 23.0 (9-1338) 33.0 P < 0.05 (16-124) 0.001* 44.5 P < 0.001 (21-208) <0.001* ALT(U/L) 22.5 (6-765) 22.0 12-99) 0.280 51.5 b (13-149) <0.001* CD4+cells (cells/μL) 388.5 (4-1601) 279.0 (1-810) 0.091 311.0 (1291238) 0.46 AST = aspartate aminotransferase, ALT = alanine aminotransferase, HIV= human immunodeficiency virus