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A Genomic Approach to Characterize the Vulnerable Patient – a Clinical Update

a knowledge-driven approach in cardiovascular disease (CVD). PLoS One . 2018;13:e0207371. 34. Csont T, Murlasits Z, Ménesi D, et al. Tissue-specific Gene Expression in Rat Hearts and Aortas in a Model of Vascular Nitrate Tolerance. J Cardiovasc Pharmacol . 2015;65:485-493. 35. Kato N, Liang Y-Q, Ochiai Y, Jesmin S. Systemic evaluation of gene expression changes in major target organs induced by atorvastatin. Eur J Pharmacol . 2008;584:376-389.

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Epicardial Fat and Coronary Vulnerability

. Measurement of epicardial fat thickness by transthoracic echocardiography for predicting high-risk coronary artery plaques. Heart Vessels . 2016;31:1758-1766. 17. Larsen BA, Laughlin GA, Saad SD, et al. Pericardial fat is associated with all-cause mortality but not incident CVD: the Rancho Bernardo Study. Atherosclerosis . 2015;239:470-475. 18. Rabkin SW, Campbell H. Comparison of reducing epicardial fat by exercise, diet or bariatric surgery weight loss strategies: a systematic review and meta-analysis. Obes Rev . 2015;16:406-415. 19. Higgins JP

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Can Erectile Dysfunction Predict Major Cardiovascular Events?

Abstract

It is estimated that erectile dysfunction (ED) affects more than 150 million people worldwide and this number is expected to double by the year 2025. Vascular component represents the most important etiological cause of erectile dysfunction. ED shares almost all risk factors, such as hypertension, diabetes mellitus, hyperlipidaemia and smoking, with arteriosclerosis. Moderate to severe ED is associated with a considerably increased risk for coronary heart disease (CHD). This review was conducted in May 2016, when the PubMed database was searched using the combination of the terms “erectile dysfunction” and “cardiovascular diseases”, “coronary artery diseases” and “risk factors”. In this review, we analyzed the published literature, regarding the predictive role of ED in CVD and the association of ED risk factors with CVD risk factors, aiming to draw particular attention on the role of sexual inquiry of all men to prevent or decrease major cardiovascular events. In conclusion, the early detection of ED can prevent major cardiovascular events with early management of cardiovascular risk and permits to include patients in a risk stratification group. Erectile function should be evaluated using questionnaires in all male patients to prevent and decrease the rates of major cardiovascular events.

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High-Risk Coronary Plaques Complicated with Acute Coronary Syndrome in Young Patients

REFERENCES 1. World Health Organization. Cardiovascular diseases (CVDs), 2017. Available from: http://www.who.int/mediacentre/factsheets/fs317/en/ . 2. Opolski MP, Kępka C, Rużyłło W. Computed tomography for detection of vulnerable coronary plaque – A Cassandra’s dream? Postępy w Kardiologii Interwencyjnej/Advances in Interventional Cardiology . 2014;10:147-152. 3. Choy SY, Mintz GS. What have we learned about plaque rupture in acute coronary syndromes? Curr Cardiol Rep . 2010;12:338-343. 4. Lafont A. Basic aspects of plaque

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Factors Associated with Development of in Coronary Stent Restenosis — the Results of a Multislice Computed Tomography 1-year Follow-up Study

Abstract

Introduction: Percutaneous coronary intervention is the first therapeutic choice in the treatment of symptomatic coronary artery disease and Multi-Slice Computed Tomography Coronary Angiography (MSCT-CA) is a new non-invasive diagnostic tool in the follow-up of these patients. The aim of our study was to evaluate the rate of in-stent restenosis (ISR), to identify the predictive factors for ISR at 1 year after PCI and to assess the progression of non-culprit lesions, using a MSCT-CA follow-up.

Material and methods: The study included 30 patients with acute coronary syndrome treated with one BMS implantation. The patients were divided into Group A (9 patients) presenting ISR and Group B (21 patients) without ISR at 1 year MSCT-CA follow-up.

Results: ISR lesions were mostly localized on the LAD (45%). No significant difference between the study groups was identified for risk factors, as male gender (77.7% vs. 85.71%, p = 0.62), hypertension (88.8% vs. 95.23%, p = 0.51), smoking status (33.3% vs. 72.22%, p = 0.23), history of CVD (55.5% vs. 47.61%, p >0.99), diabetes (11.11% vs. 19.04%, p >0.99), hyperlipidemia (22.22% vs. 52.38%, p = 0.22), CKD (44.44% vs. 14.28%, p = 0.15), age, triglycerides and SYNTAX Score. A significant difference was recorded in baseline cholesterol level (141.7 ± 8.788 vs. 182.8 ± 12; p = 0.029). Ca Score at 1 year was significantly higher in patients with ISR (603.1 ± 529.3 vs. 259.4 ± 354.6; p = 0.005). 66.67% of patients from Group A presented significant non-culprit lesions at baseline vs. 23.81% in Group B (p = 0.041).

Conclusions: MSCT-CA is a useful non-invasive diagnostic tool for ISR in the follow-up of patients who underwent primary PCI for an acute coronary syndrome. The presence of significant non-culprit lesions at the time of the primary PCI could be a predictive factor for ISR. A Ca Score >400 determined at 1-year follow-up is associated with a higher rate of ISR, and could be considered a significant cardiovascular risk factor for this group of patients. Further studies are required in order to elucidate the role of various imaging biomarkers in predicting the development of ISR.

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Positive Remodeling as a Biomarker of Plaque Vulnerability — at the Border Between Invasive and Noninvasive Assessment

REFERENCES 1. World Health Organization, Cardiovascular disease (CVDs), 2016. Available from: http://www.who.int/mediacentre/factsheets/fs317/en/# . 2. Finn AV, Nakano M, Narula J, Kolodgie FD, Virmani R. Concept of vulnerable/unstable plaque. Arteriosclerosis, thrombosis, and vascular biology . 2010;30:1282-1292. 3. Davies MJ, Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med . 1984;310:1137-1140. 4. Davies MJ. Stability and instability: two faces of coronary atherosclerosis: the Paul

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Hybrid Imaging in the Assessment of Myocardial Ischemia and Viability

References 1. World Health Organization, Cardiovascular disease (CVDs), 2016. Available from: http://www.who.int/mediacentre/factsheets/fs317/en/# 2. Townsend N, Nichols M, Scarborough P, Rayner M. Cardiovascular disease in Europe — epidemiological update 2015. Eur Heart J . 2015;36:2673-2674. 3. Nichols M, Townsend N, Scarborough P, Rayner M. Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J . 2014;35:2950-2959. 4. Camici PG, Prasad SK, Rimoldi OE. Stunning, hibernation, and assessment of myocardial viability

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Magnetic Resonance Imaging of Myocardial Function Following Intracoronary and Intramyocardial Stem Cell Injection

REFERENCES 1. European Cardiovascular Disease Statistics 2017. Avaible at: http://www.ehnheart.org/cvd-statistics.html 2. Konstam MA, Kramer DG, Patel AR, et al. Left ventricular remodeling in heart failure current concepts in clinical significance and assessment. J Am Coll Cardiol Img . 2011;4:98-108. 3. Abbate A, Biondi-Zoccai GG, Appleton DL, et al. Survival and cardiac remodeling benefits in patients undergoing late percutaneous coronary intervention of the infarct-related artery: evidence from a meta-analysis of randomized controlled

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