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.M., Maniloff, J., Mayo, M.A., McGeoch, D.J., Pringle, C.R., Wickner, R.B. (Eds) - Virus Taxonomy , Classification and Nomenclature of Viruses, Academic 339 Press, New York, pp. 835-849. Erles K., C. Toomey, H. Brooks, J. Brownlie, 2003 - Detection of a group 2 coronavirus in 345 dogs with canine infectious respiratory disease. Virology 310, 216-223. Gorbalenya A. E., L. Enjuanes, J. Ziebuhr, E.J. Snijder, 2006 - Nidovirales: evolving the 354 largest RNA virus genome. Virus Res., 117, 17-37. Pedersen Niels C., 2009 - A review of feline infectious peritonitis virus

-MS/MS system for plant metabolomics. Comput Struct Biotechnol J 4: e201301011. Wang C., Horby P.W., Hayden F.G., Gao G.F. (2020): A novel coronavirus outbreak of global health concern. The Lancet 395: 470–473.

enable them to switch to new hosts ( 49 ). These newly created viruses can acquire zoonotic potential, as witnessed by the severe acute respiratory syndrome (SARS), the epidemic from Southern China in 2003 caused by SARS-CoVs. This disease, termed “atypical pneumonia”, was diagnosed in humans in 29 countries and had a nearly 10% mortality rate. In 2012, there emerged a subsequent disease caused by a novel coronavirus, the so-called Middle East respiratory syndrome (MERS) with even higher mortality rates. Both SARS- and MERS-CoVs crossed the species barrier from bats to

REFERENCES 1. Alenius, S., Niskanen, R., Junti, N., Larsso, B. (1991). Bovine coronavirus as the causative agent of winter dysentery: serological evidence. Acta Vet Scand. 32, 163-170. PMid:1666489 2. Yang, D., Leibowitz, L. (2015). The structure and functions of coronavirus genomic 3′ and 5′ ends. Virus Res. 206, 120-133. https://doi.org/10.1016/j.virusres.2015.02.025 PMid:25736566 PMCid:PMC4476908 3. Hansa, A., Rai, R., Dhama, K., Wani, M. (2012). ELISA screening of faecal samples for bovine coronavirus and virus detection by RT-PCR in Northern India. Asian J

., Farag N.H., Haddadin A., Al-Sanouri T., Tamin A., Harcourt J.L., Kuhar D.T., Swerdlow D.L., Erdman D.D., Pallansc h M.A., Haynes L.M., Gerber S.I., Jordan MERS-Co V Investigation Team. (2014). Hospitalassociated outbreak of Middle East respiratory syndrome coronavirus:aserologic, epidemiologic, and clinical description. Clin. Infect. Dis., 59: 1225-1233. Al-Tawfiq J.A., Memish Z.A. (2014). Middle East respiratory syndrome coronavirus: epidemiology and disease control measures. Infect. Drug. Resist., 7: 281-287. Alexandersen S., Kobinger G.P., Soule G., Wernery U

ABSTRACT -

Leptospirosis is a zoonosis of constant importance as causative microbial agent, maintained by subclinical infections in wild and domestic animals. Currently, for active immunization in dogs is used an inactivated vaccine, produced by specialized companies in different countries. The vast majority are polyvalent vaccines, which include the two leptospire serovars (Leptospira canicola and Leptospira icterohaemorhagiae) and viral antigens for prevention of infectious hepatitis Rubarht, Carré's disease, coronavirus and parainfluence. Specific immunity induced by this inactivated vaccine, is active, individual, installs in 10 to 21 days after administration, lasting a variable time (4-6 months) and never causes a 100% protection. This paper aims to investigate how this immune response in carnivores and its protection.

Abstract

This study investigated for 14 days post-weaning, the influence of dietary supplementation of synbiotics in the form of probiotic cheeses containing cultures of L. plantarum and L. fermentum and crushed flaxseed (source of ω-3 polyunsaturated fatty acids — PUFAs and fibre) on 36 commercial piglets originating from an infected herd (Coronavirus and E. coli) during the critical period of weaning. We focused on the health and metabolism of PUFAs in this critical period of a piglet’s life. The dietary supplementation positively affected: the overall health state of weaners, reduced diarrhoea by 29 % by 14 days post-weaning and significantly increased the counts of lactic acid bacteria, bifidobacteria and the production of volatile fatty acids. The PUFA concentrations in the m. biceps femoris of the piglets were analysed by gas chromatography. High levels of ω-3 alpha-linolenic acid (ALA) in flaxseed increased significantly the level of ALA, eicosapentaenic acid (EPA) and docosahexaenic acid (DHA) in the pig muscles on days 7 and 14 post-weaning. The levels of ω-6 linolenic acid (LA) were less affected by the diet, but were increased on day 14 post-weaning, while the conversion products of LA, and arachidonic acid (AA), were decreased on days 7 and 14. The increased level of dietary ALA favoured the activity of Δ-6-desaturase for the conversion of ALA to EPA and DHA, at the expense of AA synthesis from LA. The ability of synbiotics to incorporate high levels of DHA in the pig muscles appear prospective for improving the nutritional properties of pork and reducing the occurrence of civilization diseases in consumers of this product of animal origin.

-B), Picornaviruses (e.g., human rhinovirus), coronaviruses (e.g., human coronavirus), Pneumoviridiae (e.g., human metapneumovirus), and potentially other viruses. Diagnostics of viral infections in hematological patients Laboratory test for viral infections with focus on latent and chronic infections should be performed in many hematological conditions, especially at diagnosis of the disease, and before HCT (both in recipient and donor). Additionally, after HCT monitoring for CMV and EBV, reactivation is mandatory in allo-HCT setting, and for several other viruses

infectious bronchitis virus isolated from domestic chicken flocks and coronaviruses from feral pigeons in Brazil between 2003 and 2009. Avian Dis. , 54, 1191—1196. 12. Ganapathy, K., Wilkins, M., Forrester, A., Lemiere, S., Cserep, T., Mcmullin, P., Jones, R. C., 2012: QX-like infectious bronchitis virus isolated from cases of proventriculitis in commercial broilers in England. Vet Rec. , 171, 597. 13. Guy, J. S., 2000: Turkey coronavirus is more closely related to avian infectious bronchitis virus than to mammalian coronaviruses. Avian Pathol. , 29, 2017—212. 14

hepatitis virus (MHV), infectious bronchitis virus (IBV), severe acute respiratory syndrome-coronavirus (SARS-CoV), and other coronaviruses can cause G0/G1- or G2/M-phase arrest ( 3 , 7 , 19 , 26 , 27 , 28 ). Nevertheless, the mechanisms by which epidemic strains of PEDV affect the mammalian cell cycle have not been elucidated. In this study, Vero cells were infected with the epidemic SHpd/2012 PEDV strain to determine the effect on cell cycle progression, to explore the molecular mechanisms producing the effects of PEDV on the cell cycle, and to provide theoretical