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.M., Maniloff, J., Mayo, M.A., McGeoch, D.J., Pringle, C.R., Wickner, R.B. (Eds) - Virus Taxonomy , Classification and Nomenclature of Viruses, Academic 339 Press, New York, pp. 835-849. Erles K., C. Toomey, H. Brooks, J. Brownlie, 2003 - Detection of a group 2 coronavirus in 345 dogs with canine infectious respiratory disease. Virology 310, 216-223. Gorbalenya A. E., L. Enjuanes, J. Ziebuhr, E.J. Snijder, 2006 - Nidovirales: evolving the 354 largest RNA virus genome. Virus Res., 117, 17-37. Pedersen Niels C., 2009 - A review of feline infectious peritonitis virus

References 1. Abdelmageed MI, Abdelmoneim AH, Mustafa MI, Elfadol NM, Murshed NS, Shantier SW, Makhawi AM (2020) Design of multi epitope-based peptide vaccine against E protein of human 2019-nCoV: An immunoinformatics approach. BioRxiv 2020.02.04.934232. doi: 10.1101/2020.02.04.934232 2. Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR (2018) Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase

ABSTRACT -

Leptospirosis is a zoonosis of constant importance as causative microbial agent, maintained by subclinical infections in wild and domestic animals. Currently, for active immunization in dogs is used an inactivated vaccine, produced by specialized companies in different countries. The vast majority are polyvalent vaccines, which include the two leptospire serovars (Leptospira canicola and Leptospira icterohaemorhagiae) and viral antigens for prevention of infectious hepatitis Rubarht, Carré's disease, coronavirus and parainfluence. Specific immunity induced by this inactivated vaccine, is active, individual, installs in 10 to 21 days after administration, lasting a variable time (4-6 months) and never causes a 100% protection. This paper aims to investigate how this immune response in carnivores and its protection.

Program. Cornell University, Cooperative Extension. Saif L.J. & Wesley R.D. (1999): Transmissible gastroenteritis coronavirus and Porcine respiratory coronavirus. Dis. swine 8th ed : 325-395. Sasaki T., Kobayashi M., Agui N. (2000): Epidemiological potential of excretion and regurgitation by Musca domestica (Diptera: Muscidae) in the dissemination of Escherichia coli O157: H7 to food. J. Med. Entomol., 37(6): 945-949. Shono T., Zhang L., Scott J.G. (2004): Indoxacarb resistance in the house fly, Musca domestica. Pestic. Biochem. Physiol., 80: 106-112. Siri A