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I. Capík and O. Nagy

. Mastrocinque, S., Fantoni, D. T., 2003: A comparison of preoperative tramadol and morphine for the control of early postoperative pain in canine ovariohysterectomy. Vet. Anaesth. Analg., 30, 220-228. 8. Moody, D. E., Fang Lin, S. N., Weyant, D. M., Strom, S. C., Omiecinski, C. J., 2009: Effect of Rifampin and Nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes. Drug Metab. Dispos., 37, 2323-2329. 9. Paul-Murphy, J. R., Brunson, D. B., Miletic, V., 1999: Analgesic effects of butorphanol and

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Alenka Akšamija, Gordana Horvat, Dubravko Habek, Damir Žalac and Eva Jendriš

;4:184-6. Paterna JC, Boess F, Stäubli A, Boelsterli UA. Antioxidant and cytoprotective properties of D-tagatose in cultured murine hepatocytes. Toxicol Appl Pharmacol 1998;148:117-25. Kelly BD, Heneghan MA, Bennani F, Connolly CE, O'Gorman TA. Nitrofurantoin-induced hepatotoxicity mediated by CD8+ T cells. Am J Gastroenterol 1998;93:819-21. Paiva LA, Wright PJ, Koff RS. Long-term hepatic memory for hypersensitivity to nitrofurantoin. Am J Gastroenterol 1992;87:891-3.

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Monika Johansson, Jana Tomankova, Shengjie Li and Galia Zamaratskaia

metabolism - Basic concepts and methods of assessment. Cell Mol Neurobiol 19: 309-323. Jurica J, Kyr M, McCaskey Hadasova E, Tomandl J. (2009). Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration. Neuroendocrinol Lett 30 (Suppl 1): 92-95. Lahoz A, Donato MT, Montero S, Castell JV, Gómez-Lechón MJ. (2008). A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations. Rapid Commun . Mass Spectrom 22: 240

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Hinako Sashida, Ryô Harasawa, Toshihiro Ichijo, Hiroshi Satoh and Kazuhisa Furuhama

R., Parbhoo S.P.: Haemolytic anaemia in the Gunn rat following transplantation of isolated hepatocytes injected with Haemobartonella muris. Br J Exp Pathol 1981, 62, 8-12.

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Muhammad Osama Butt, Nasir Hassan Luck, Syed Mujahid Hassan, Zaigham Abbas and Muhammed Mubarak

( Figure 1 ). There was scanty fibrosis in between the hepatocytes. The features were suggestive of early PH. Figure 1 Liver biopsy findings on histopathology. (A) Low-power view showing dilated and congested sinusoids. (Hematoxylin and eosin [H&E], ×100); (B) Medium-power view showing dilated and congested sinusoids (H&E, ×200); (C) Low-power view showing one cystic space filled with red blood cells (H&E, ×100); (D) Reticulin stain highlighting the cystic space filled with blood (reticulin, ×200) She was managed conservatively and advised for regular

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K. Stebelova, J. Kosnacova and M. Zeman

. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 338, 1422-1426, 1998. Graham C, Cook MR, Kavet R, Sastre A, Smith DK. Prediction of nocturnal plasma melatonin from morning urinary measures. J Pineal Res 24, 230-238, Erratum in: J Pineal Res 26, 128, 1999, 1998. Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR. Melatonin - a pleiotropic, orchestrating regulator molecule. Prog Neurobiol 93, 350-384, 2011. Karasek M. Melatonin, human aging, and age

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Agnieszka Pedrycz, Małgorzata Tomasiak and Beata Cichacz

References 1. Allyson L., Anding, Eric H. Baehrecke.: Autophagy in Cell Life and Cell Death. www.sciencedirect.com/science/article/pii/S0070215315000484, 2015 2. Baran P.: Death types analysis of liver hepatocytes in pregnant female rats induced by the preeclampsia imposed on the nephrotic syndrome. Doctoral thesis 2013 3. Clausen T.H., Lamark T., Isakson P., Finley K., Larsen K.B., Brech A., Overvatn A., Stenmark H., Bjorkoy G., Simonsen A., Johansen T.: p62/SQSTM1 and ALFY interact to facilitate the formation

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Ela Andra Cocariu, V. Mageriu, Florica Stăniceanu, Alexandra Bastian, C. Socoliuc and Sabina Zurac

G, JORIS I. Cells , Tissues and Disease: Principles of General Pathology , 2 nd Edition, Oxford University Press, 2004. 12. KARADŽIĆ R, ILIĆ G, ANTOVIĆ A, BANOVIĆ LK. Autolytic ultrastructural changes in rat and human hepatocytes . Rom J Leg Med 2010; 18 :247 – 52. 13. GUNDLACH G, LUTTERMANN-SEMMER E. The effect of pH and temperature on the stability and enzymatic activity of prostatic acid phosphatase. Studies on the optimization of a continuous monitored determination of acid phosphatase . J Clin Chem Clin Biochem. 1987; 25 (7):441-6. 14

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Doaa Mahmoud-Ghoneim, Amr Amin and Peter Corr

D, Benedetti A, Francis H, et al. Taurocholate feeding prevents CCl 4 -induced damage of large cholangiocytes through PI3-kinase-dependent mechanism, Am J Physiol-Gastr Liver Physiol 2003; 284 : G290-301. Gagandeep S, Rajvanshi P, Sokhi RP, Slehria S, Palestro CJ, Bhargava KK, et al. Transplanted hepatocytes engraft, survive and proliferate in the liver of rats with carbon tetrachloride-induced cirrhosis. J Pathol 2000; 191 : 78-85. Cai J, Ito M, Nagata H, Westernman KA, Lafleur D, Chowdhury JR, et al

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Roberta Klobučar, Roko Žaja, Damjan Franjević, Anamaria Brozović and Tvrtko Smital

, Sauerborn Klobučar R, Smital T. Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line. Aquat Toxicol 2007;81:365-76. Žaja R, Munić V, Sauerborn Klobučar R, Ambriović-Ristov A, Smital T. Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol 2008;90:322-32. Cai S-Y, Soroka CJ, Ballatory N, Boyer JL. Molecular characterization of a multidrug