Maria-Magdalena Sandu, Diana Cristina Protasiewicz, Adela Gabriela Firănescu, Elena Cristina Lăcătuşu, Mihaela Larisa Bîcu and Maria Moţa
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9. Colagiuri S, Borch-Johnsen K, Glümer C, Vistisen D. There really is an epidemic of type 2 diabetes. Diabetologia 48: 1459–1463, 2005.
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11. Gregg EW, Cadwell BL, Cheng YJ et al. Trends in the prevalence and ratio of diagnosed to undiagnosed diabetes according to obesity levels in the U.S. Diabetes Care 27: 2806
1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047-1053, 2004.
2. Panzram G. Mortality and survival in type 2 (non-insulindependent) diabetesmellitus. Diabetologia 30: 123-131, 1987.
3. Pahor M, Elam MB, Garrison RJ, Kritchevsky SB, Applegate WB. Emerging noninvasive biochemical measures to predict cardiovascular risk. Arch Intern Med 159: 237-245, 1999.
4. Gerstein HC, Mann JF, Pogue J et al . Prevalence and
M Šeruga, J Makuc, M Završnik, I Cilenšek, R Ekart and D Petrovič
Type 2 diabetesmellitus (T2DM) is a multifactorial chronic metabolic disease characterized by post-prandial hyperglycemia that causes long-term macrovascular or microvascular complications. Microvascular complications are diabetic nephropathy (DN), neuropathy and diabetic retinopathy (DR) [ 1 , 2 ]. Diabetesmellitus (DM) is the most common cause of chronic kidney disease and end-stage renal disease [ 1 , 2 ]. In the pathogenesis of DN several environmental, genetic, and epigenetic factors are involved in complex interactions [ 3 - 5 ].
Cristian Serafinceanu, Viviana Elian, Doina Catrinoiu, Cristian Guja, Bogdan Mihai, Maria Mota, Gabriela Roman and Romulus Timar
1. International Diabetes Federation. The Global Picture in IDF Diabetes Atlas Eight Edition 2017; 40:65, 2017
2. Roman G, Bala C, Creteanu G et al. Obesity and health-related lifestyle factors in the general population in Romania: a cross sectional study. Acta Endocrinologica (Buc) 11(1): 64-71, 2015.
3. Mota M, Popa SG, Mota E et al. Prevalence of diabetesmellitus and prediabetes in the adult Romanian population: PREDATORR study. J Diabetes 8(3):336-44, 2016.
4. KDIGO 2012 Clinical
3. The BARI Investigators. Seven-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status. J Am Coll Cardiol2000; 35:1122-9. http://dx.doi.org/10.1016/S0735-1097(00)00533-7
4. Kang X, Berman DS, Lewin HC, Cohen I, Friedman JD, Germano G, et al. Incremental prognostic value of myocardial perfusion single photon emission computed tomography in patients with diabetesmellitus. Am Heart J 1999;138:1025-32 http://dx.doi.org/10.1016/S0002
Cristina Căpăţînă, Ionela Baciu, Daniela Greere, Andra Caragheorgheopol and Cătălina Poiană
Background and aims. Endogenous Cushing’s syndrome is a rare disease associated with severe morbidity and increased mortality if untreated. Diabetes mellitus is a frequent initial complaint of these patients. Our aim was to investigate the clinical characteristics at the time of diagnosis in a cohort of patients with endogenous Cushing’s syndrome (CS).
Material and methods. A retrospective analysis of the presentation of 68 cases diagnosed with endogenous Cushing’s syndrome followed-up in our institution was performed.
Results: There were 57 women and 11 men, aged 18-74 years (mean 45.57±14.2). 38 had Cushing’s disease (CD) while 30 had adrenal CS. The most frequent signs/symptoms leading to the initial consultation and diagnostic suspicion were central obesity (55 cases, 80.88%), purple striae (28 cases, 41.1%), secondary arterial hypertension (27 cases, 39.7%), secondary diabetes mellitus (24 cases, 35.29%), hirsutism in 23/55 women (41.81%), hypogonadism in 23 cases (33.82%), proximal myopathy in 17 cases (25%), edema (10 cases, 14.7%). 13 cases (19.11%) also had secondary osteoporosis (diagnosed by dual energy x-ray absorptiometry - DXA osteodensitometry). Among the two diagnostic groups there were several differences. Proximal myopathy, secondary hypertension and diabetes mellitus were all more frequent in cases with adrenal Cushing compared to those with CD. (p= 0.011, 0.006 and 0.024, respectively). This did not reflect more severe hypercortisolism in adrenal CS, as the hormonal values were similar in the two groups.
Conclusion: If associated with certain clinical signs, some nonspecific (central obesity, edema, arterial hypertension), other more suggestive of CS (purple striae, proximal myopathy) diabetes mellitus could be the initial sign of this severe condition.
alban , P. A., D onath , M. Y. (2002): Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest. , 110: 851 – 860. DOI: 10.1172/jci15318
N agakubo , D., S hirai , M., N akamura , Y., K aji , N., A risato , C., W atanabe , S., T akasugi , A., A sai , F. (2014): Prophylactic effects of the glucagon-like Peptide-1 analog liraglutide on hyperglycemia in a rat model of type 2 diabetesmellitus associated with chronic pancreatitis and obesity. Comp. Med. , 64: 121 – 127
O kamoto , M., T aira , K
S Merlo, J Novák, N Tkáčová, J Nikolajević Starčević, M Šantl Letonja, J Makuc, A Cokan Vujkovac, J Letonja, D Bregar, M Zorc, M Rojko, S Mankoč, P Kruzliak and D Petrovič
Type 2 diabetesmellitus (T2DM) represents a chronic illness characterized by the disability of the body to utilize glucose either because of insulin resistance in peripheral tissues or because of a decreased production of insulin by the pancreas [ 1 ]. Type 2 diabetesmellitus is known to promote the atherosclerotic process, which is characterized by endothelial dysfunction and by accumulation of foam cells and vessel wall inflammation. As the process continues, the narrowing of the vessel lumen occurs, leading to acute cardiovascular events
Adela-Gabriela Firănescu, Adina Popa, Maria-Magdalena Sandu, Diana Cristina Protasiewicz, Simona Georgiana Popa and Maria Moţa
1. Morton R. Phthisiologia: or a treatise of consumptions. London: Smith and Walford , 1694.
2. Rajalakshmi S, Veluchamy G. Yugi's pramegam and diabetesmellitus: an analogue. Bull Indian Inst Hist Med Hyderabad 29: 83–87, 1999.
3. Harries AD, Satyanarayana S, Kumar AMV et al. Epidemiology and interaction of diabetesmellitus and tuberculosis and challenges for care: a review. Public Health Action 3 [Suppl 1]: S3-S9, 2013.
4. Dooley KE, Chaisson RE. Tuberculosis and diabetesmellitus: convergence of two epidemics
Sorina Alina Cristea, Doina Catrinoiu and L. R. Craciun
Background: The last International Diabetes Federation statement showed that in 2015, there were 415 million people diagnosed with diabetes and the expectation for 2040 is around 642 million people all over the world. Diabetes Mellitus is a disease associated with major negative consequences due to its acute and chronic complications with chronic hyperglycemia playing a major role.
Method: We are presenting a case of 52 year old male patient, known with Type 2 Diabetes Mellitus for 10 years without treatment due to personal decision, who was admitted through the Emergency Unit in Neurology Department for bilateral myalgia of hips and arms, proximal force deficiency of bilateral lower limbs, acute retention of urine, fever, simptomatology which started about 48 before admission. The suspected diagnosis was acute polyradiculoneuritis but the paraclinical investigations performed on Neurology Unit excluded it and evaluated the present disease as Acute Diabetic Neuropathy. Through the passing days, the patient developed paraplegia and major unbalanced glycemic control (although he received multiple rapid human subcutaneous insulin injection) so they’ve decided to transfer him into Diabetology Department. At the moment of admission into Diabetology Unit, the patient had high fever, superficial and deep sensitivity disorders, urethral catheter and no faeces for 7 days. We’ve continued our investigations and came with a positive diagnosis of Unballanced and Complicated Type 2 Diabetes Mellitus with insulin therapy, Parainfectious Acute Transverse Myelitis, Prostatic and Seminal Vesicles Abces with rectal fistula, Sepsis, Acute Retention of Urine, Urina Infection with Pseudomonas Aeruginosa.
Conclusion: The diagnosis of Unballanced Diabetes Mellitus involves differential diagnosis due to lack of specific simptomatology in Diabetic Neuropathy and associated immune deficiency.