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Relationship Between Apoptotic-Like Changes in Stored Boar Semen and DNA Fragmentation in Preimplantation Embryos

References Anzar M., Liwei H., Buhr M. M., Kroetsch T. G., Pauls K. P. (2002). Sperm apoptosis in fresh and cryopreserved bull semen detected by flow cytometry and its relationship with fertility. Biol. Reprod., 66: 354-360. Brison D. R., Schultz R. M. (1997). Apoptosis during mouse blastocyst formation: evidence for a role for survival factors including transforming growth factor. Biol. Reprod., 56: 1088-1096. Bryła M., Trzcińska M., Wieczorek J. (2009). Analysis of in vivo - and

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Hydrazinyldiene-chroman-2,4-diones in inducing growth arrest and apoptosis in breast cancer cells: Synergism with doxorubicin and correlation with physicochemical properties

. Jashari, E. Popovski, P. B. Selmani, B. Mikhova, G. Dräger, E. Alili-Idrizi and K. Mladenovska, Synergy of novel coumarin derivatives and tamoxifen in blocking growth and inducing apoptosis of breast cancer cells, Mac. Pharm. Bull. 60 (2014) 35-44. 14. N. C. Bols, V. R. Dayeh, L. E. J. Lee and K. Schirmer, Use of Fish Cell Lines in the Toxicology and Ecotoxicology of Fish, in Biochemistry and Molecular Biology of Fishes - Environmental Toxicology (Eds. T. P. Mommsen and T. W. Moon), Vol. 6, Elsevier Science, Amsterdam 2005, pp. 43

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Carbon nanotubes with controlled length – preparation, characterization and their cytocompatibility effects

.1016/j.ijbiomac.2010.01.006. 10. Elgrabli, D., Abella-Gallart, S., Robidel, F., Rogerieux, F., Boczkowski, J. & Lacroix, G. (2008). Induction of apoptosis and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes. Toxicology, 253, 131–136. DOI: 10.1016/j.tox.2008.09.004. 11. De Nicola, M., Gattia, D.M., Bellucci, S., Bellis, G.D., Micciulla, F., Pastore, R., Tiberia, A., Cerella, C., D’Alessio, M., Antisari, M.V., Marazzi, R., Traversa, E., Magrini, A., Bergamaschi, A. & Ghibelli, L. (2007). Effect of

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The Relationship Between Apoptotic Activity and Prognostic Factors in Neuroblastomas

based on recommendations of international neuroblastoma pathology committee (Modification of shimada classification). Pediatr Dev Pathol. 2000;3:184-99. 4. Hiyama E, Hiyama K, Ohtsu K, Yamaoka H, Ichikawa T, Shay JW, Yokoyama T. Telomerase activity in neuroblastoma: Is it a prognostic indicator of clinical behaviour?. Eur J Cancer. 1997;33:1932-6. 5. Schwab M, Westermann F, Hero B, Berthold F. Neuroblastoma: Biology and molecular and chromosomal pathology. Lancet Oncol. 2003;4:472-80. 6. Tsujimoto Y. Role of Bcl-2 family proteins in apoptosis

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Immunohistochemical study of Aquaporin-1, Cyclooxygenase-2 and Apoptosis Protease-Activating Factor-1 expression in breast cancers. Preliminary study

-85 5. Rolland, P.H., Martin, P.M. & Jacquemier, J. et al. (1980). Prostaglandin in human breast cancer: evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells. J Natl Cancer Inst. 64, 1061-1070 6. Khuder, S.A. & Mutgi, A.B. (2001). Breast cancer and NSAID use: a meta-analysis. Br J Cancer. 84, 1188-1192 7. Campioni, M., Santini, D., Tonini, G., Murace, R., Dragonetti, E. & Spugnini, E.P. et al. (2005). Role of Apaf-1, a key regulator of apoptosis, in melanoma

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Analysis of proapoptotic changes in boar spermatozoa stored at 16 °C in different short-term semen extenders

References 1. Anzar M., He L., Buhr M.M., Kroetsch T.G., Pauls K.P.: Sperm apoptosis in fresh and cryopreserved bull semen detected by flow cytometry and its relationship with fertility. Biol Reprod 2002, 66 , 354-360. 2. Fraser L., Lecewicz M., Strzeżek J.: Fluorometric assessments of viability and mitochondrial status of boar spermatozoa following liquid storage. Pol J Vet Sci 2002, 5 , 85-92. 3. Fraser L., Pareek C.S., Strzeżek J.: Identification of amplified fragment length polymorphism markers

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Correlation between expressions of hypoxia -inducible factor (HIF-1α), blood vessels density, cell proliferation, and apoptosis intensity in canine fibromas and fibrosarcomas

their microenvironment. Cancer Cell 2003, 4, 133-146. 6. Bos R., Zhong H., Hanrahan C.F., Mommers E.C., Semenza G.L., Pinedo H.M., Abeloff M.D., Simons J.W., van Diest P.J., van der Wall E.: Levels of hypoxia-inducible factor-1α during breast carcinogenesis. J Natl Cancer Inst 2001, 93, 309-314. 7. Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C.J., Ratcliffe P., Moons L., Jain R.K., Collen D., Keshert E.: Role of HIF-1α in hypoxia-mediated apoptosis

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Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities

. Tomasi, S. Laufer and T. Guarnieri, Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade, Carcinogenesis 29 (2008) 371–380; https://doi.org/10.1093/carcin/bgm265 14. S. Tavolari, A. Munarini, G. Storci, S. Laufer, P. Chieco and T. Guarnieri, The decrease of cell membrane fluidity by the non-steroidal anti-inflammatory drug Licofelone inhibits epidermal growth factor receptor signalling and triggers apoptosis in HCA-7 colon

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Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study

Abstract

Extensive in vitro studies have been conducted to evaluate the anticancer activity of oral hypoglycemic agents. Many of these studies experienced detrimental limitations, since they were conducted on cancer cells commonly grown in culture media consisting of extremely high concentrations of growth factors and glucose. The present study was aimed at exploring the antiproliferative effects of the commonly studied metformin and the less frequently reported phenformin oral hypoglycemic agents on different molecular subtypes of breast cancer under rich glucose and glucose deprived conditions. Our results indicate that under glucose deprived conditions, which better reflect the factual glucose-starved solid tumors in vivo, biguanides exert more antiproliferative activities against the three molecular subtypes of breast cancer cell lines examined in this study. In addition, the observed antiproliferative activities of biguanides appear to be mediated by apoptosis induction in breast cancer cells. This induction is significantly augmented under glucose deprived conditions.

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Evaluation of miR-9 and miR-143 expression in urine specimens of sulfur mustard exposed patients

Abstract

Sulfur mustard (SM) or mustard gas is a chemical alkylating agent that causes blisters in the skin (blister gas), burns the eyes and causes lung injury. Some major cellular pathways are involved in the damage caused by mustard gas such as NF-κb signaling, TGF-β signaling, WNT pathway, inflammation, DNA repair and apoptosis. MicroRNAs are non-coding small RNAs (19–25 nucleotides) that are involved in the regulation of gene expression and are found in two forms, extracellular and intracellular. Changes in the levels of extracellular microRNAs are directly associated with many diseases, it is thus common to study the level of extracellular microRNAs as a biomarker to determine the pathophysiologic status. In this study, 32 mustard gas injured patients and 32 healthy subjects participated. Comparative evaluation of miR-9 and miR-143 expression in urine samples was performed by Real Time PCR and Graph Pad software. The Mann Whitney t-test analysis of data showed that the expression level of miR-143 and miR-9 had a significant decrease in sulfur mustard individuals with the respective p-value of 0.0480 and 0.0272 compared to normal samples, with an imbalance of several above mentioned pathways. It seems that reducing the expression level of these genes has a very important role in the pathogenicity of mustard gas injured patients.

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