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Altered canonical hedgehog-gli signalling axis in pesticide-induced bone marrow aplasia mouse model

and immunosuppression: the risks to public health. Health Policy Plan 1997;12:97-106. 14. Kevin Y, Urayama JK, Wiencke B, Chokkalingam AP, Metayer C, Wiemels JL. MDR1 Gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 2007;16:1172-7. 15. Ledirac N, Antherieu S, Uby AD, Caron JC, Rahmani R. Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive oxygen species. Toxicol Sci 2005

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Infectious complications in children and adults with hematological malignancies

]. Fig. 1 Overall cumulative incidence of infections in pediatric hematology and oncology (PHO) and pediatric hematopoietic stem cell transplantation (HCT) settings between 2012 and 2017: (A and B) including possible, probable, and proven IFD; (C and D) including probable and proven but not possible IFD Infections in pediatric hematology and oncology setting Acute lymphoblastic leukemia (ALL) The analysis included 1363 patients, with newly diagnosed ALL (2012–2017). The patients received therapy according to the ALL IC-BFM 2002 and 2009 (Intercontinental

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Therapy-related myelodysplastic syndrome after successful treatment of acute promyelocytic leukemia: case report and literature review

, Al - Modhwahii, Andersen MK, Behrendtz M, Forestier E, Hasle H, et al. Methotrexate (6- mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia. Results from the NOPHO ALL- 92 study. Blood 2009;113:6077-884. DOI: 10.1182/blood-2008-11-187880 29. Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood 2017 Jan;129(4):424-47. DOI: 10.1182/blood-2016

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Association Between Glutathione S-Transferase Omega 1 A140D Polymorphism in the Turkish Population and Susceptibility to Non-Small Cell Lung Cancer

, Tjonneland A. Polymorphisms of glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women. Eur J Cancer Prev 2008;17:225-9. doi: 10.1097/ CEJ.0b013e3282b6fe1e 24. Pongstaporn W, Pakakasama S, Sanguansin S, Hongeng S, Petmitr S. Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia. J Cancer Res Clin Oncol 2009;135:673-8. doi: 10.1007/s00432-008-0501-4 25. Wang YH, Yeh SD, Shen KH, Shen CH, Juang GD, Hsu LI, Chiou HY, Chen CJ. A significantly joint

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Review. Development, Applications, Benefits, Challenges and Limitations of the New Genome Engineering Technique. An Update Study

. 35. Kim E, Hurtz C, Koehrer S, et al. Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK. Blood. 2016. doi.org/10.1182/blood-2016-06-722900. 36. Huibin T, Joseph BS. CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer: a personalized molecular surgical therapy. EMBO. 2016;8(2):83-85. 37. Xun LX, Leqiang S, Teng Y, et al. A CRISPR/Cas9 and Cre/Lox systembased express vaccine development strategy against reemerging Pseudorabies virus. Sci Rep. 2016; 6

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Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cells (CAR-T) immunotherapy: a systematic review of case reports

immunotherapy for refractory acute lymphocytic leukemia. Chin J Blood Transfusion. 2016;29:1104-1107 (in Chinese). Chen XL Feng YM Zeng YJ Exploration of integrated nursing care on CAR-T cell immunotherapy for refractory acute lymphocytic leukemia Chin J Blood Transfusion 2016 29 1104 1107 (in Chinese) 15 Feng N, Du X, Zhang C, Hao J, Zeng L. Nursing care of patients with recurrent refractory acute lymphoblastic leukemia treated with chimeric antigen receptor. Chongqing Med. 2016;45:140-141 (in Chinese). Feng N Du X Zhang C Hao J Zeng

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CYP3A5 Polymorphism In Serbian Paediatric Epileptic Patients On Carbamazepine Treatment

in a Japanese population. Hum Mutat 2003; 618:1-7. 35. Arvanitidis K, Ragia G, Iordanidou M, et al. Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population. Fundam Clin Pharmacol 2007; 21(4):419-26. 36. Hilli J, Rane A, Lundgren S, et al. Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population. Fundamental & Clinical Pharmacology 2007; 21:379–86. 37. Borst L, Wallerek S, Dalhoff K, et al. The impact of CYP3A5*3 on risk and prognosis in childhood acute lymphoblastic

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Application of Genomics in Clinical Oncology

genome epidemiology. Nat Genet 2006; 38 : 3-5. Grimwade D, Haferlach T. Gene expression profiling in acute myeloid leukemia. N Engl J Med 2004; 350 ; 16 : 1676-8. Xiong H, Chen YW. Kernel-based distance metric learning for microarray data classification. BMC Bioinformatics 2006; 7 : 299. Yeoh EJ, Ross ME, Shirtleff SA, Williams WK, Patelo D, Mahariz R, et al. Classification subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene profiling

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Study of CD25 expression on leukemic cells: a prognostic factor in acute myeloid leukemia

receptor induces T-cell proliferation and differentiation [ 8 ]. Recent research has described CD25 as a poor prognostic factor in acute lymphoblastic leukemia [ 9 ]. Moreover, in AML, previously published data from small retrospective studies have suggested an unfavorable impact of CD25 [ 10 , 11 ]. Therefore, our aim was to evaluate the expression of CD25 in adult Egyptian patients with newly diagnosed AML and thereafter study its impact on prognosis. 2 Subjects and methods The current study was conducted with 50 newly diagnosed adult AML patients before

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LncRNA NEAT1 promotes endometrial cancer cell proliferation, migration and invasion by regulating the miR-144-3p/EZH2 axis

EC cells inhibited cancer cell proliferation, migration and invasion, which are consistent with of the results of Dong et al . These results suggested that NEAT1 may play carcinogenic roles in the progression of EC. Acting as a competitive endogenous RNAs, lncRNAs regulate protein expression by binding to miRNAs. For example, NEAT1 inhibits glioma cell migration and invasion via modulating SOX2 by targeting miR-132. 19 In acute lymphoblastic leukaemia, NEAT1 can regulate miR-335-3p expression, and the dysregulation of miR-335-3p is associated with poor

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