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Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method

). Biotransformation, hepatopancreas DNA binding and pharmacokinetics of benzo[a]pyrene after oral and parenteral administration to the American lobster, Homarus americanus. Chem Biol Interact   95 : 141-160. James MO, Altman AH, Morris K, Kleinow KM, Tong Z. (1997). Dietary modulation of phase 1 and phase 2 activities with benzo(a)pyrene and related compounds in the intestine but not the liver of the channel catfish, Ictalurus punctatus. Drug Metab Dispos   25 : 346-354. Jiang H, Gelhaus SL, Mangal D, Harvey RG, Blair IA

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Developmentand Validation of a Questionnaire about Patient Knowledge of Adverse Effects of Statins

References 1. Bellosta S, Paoletti R, Corsini A. Safety of statins: focus on clinical pharmacokinetics and drug interactions. Circulation. 2004;109(Suppl):III50-7. http://dx.doi.org/10.1161/01.cir.0000131519.15067.1f 2. Shankar-Hari M, Kruger PS, Di Gangi S et al. Statin therapy in critical illness: an international survey ofintensive care physicians’ opinions, attitudes and practice. BMC Clin Pharmacol. 2012;12:13-20. http://dx.doi.org/10.1186/1472-6904-12-13 3. Jukema JW, Cannon CP, de Craen AJ et al. The

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Osteoporosis: Therapeutic Options

combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older a meta analyse. Lancet 2007;370:657-66. 36. Mithal A, Wahl DA, Bonjour J. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009;20(11):1807-20. 37. Bikle D. Vitamin D and bone. Curr Osteoporos Rep 2012;10(2):151-9. 38. Russell R. Bisphosphonates: from bench to bedside. Ann N Y Acad Sci 2006;1068:367-401. 39. Kimmel B. Mechanism of action, pharmacokinetics and

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The Wnt Signalling Pathways: A Short Review and Specific Roles in Bone Biochemistry

-related stimulus toward a cure for osteoporosis, Frontiers in Endocrinology, 2015; 6:1-4 39. Fulciniti M, Tassone P, Hideshima T et al. - Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma, Blood Journal, 2009; 114:371-379 40. Goldstein SD, Trucco M, Guzman WB et al. - A monoclonal antibody against the Wnt signaling inhibitordickkopf-1 inhibits osteosarcoma metastasis in a preclinical model, 2016; Oncotarget, 7:21114-21123 41. Betts AM, Clark TH, Yang J et al. – The application of target information and preclinical pharmacokinetic

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Cognitive Impairment in Schizophrenia, Neurotransmitters and the New Atypical Antipsychotic Aripiprazole

’s essential psychopharmacology: the prescriber’s guide. Antidepressants 4th ed. New York; Cambridge University Press; 2011:22. 24. Kubo M, Koue T, Maune H, et al. Pharmacokinetics of aripiprazole, a new antipsychotic, following oral dosing in healthy adult Japanese volunteers: influence of CYP2D6 polymorphism. Drug Metab Pharmacokinet 2007;22(5):358-66. 25. Burstein ES, Ma J, Wong S, et al. Intrinsic Efficacy of Antipsychotics at Human D2, D3, and D4 Dopamine Receptors: Identification of the Clozapine Metabolite N-Desmethylclozapine as a D2/D

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Updates on the Treatment of Pterygium

. (1991). Lipophilicity, solubility and permeability of loteprednol etabonate: a novel, soft anti-inflammatory steroid. J Biopharm Sci. 2(2):115-25. 32. Wu WM, Huang F, Lee Y, Buchwald P, Bodor N. (2008). Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats. J Pharm Pharmacol. 60(3):291-7. 33. Nguyen HT, Samudre SS, Lattanzio FA, Williams PB, Sheppard JD. (2008). Loteprednol etablonate reduces Inflammatory Response associated with Pterygium Progression. Investig Ophthalmol Vis Sci 49: 6027. 34. Karalezli A, Kucukerdonmez C

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Efficacy of Intravenous Administration of Iron Sucrose for Treatment of Iron Deficiency Anaemia in Patients With Abnormal Uterine Bleeding

-2115(03)00113-1 Hashmi Z, Bashir G, Azeem P, Shah S. Effectiveness of intravenous iron sucrose complex versus intramuscular iron sorbitol in iron deficiency anemia Ann Pak Inst Med Sci 2006; 2: 188-91. Petewusnyk G, Huch R, Huch A, Breymann C. Parenteral iron therapy in obstetrics: 8 years experience with iron-sucrose complex. Br J Nutr 2002;88:3-10. http://dx.doi.org/10.1079/BJN2002577 Danielson B G. Structure, Chemistry, and Pharmacokinetics of Intravenous Iron Agents J Am Soc Nephrol 2004; 15: 93

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Changes In QTc Interval Duration Among Heroin Addicts On Methadone Treatment

. Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin. Pharmacokinet.41, 1153–1193 (2002). 8. Gerber, J.G., Rhodes, R.J. & Gal, J. Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19. Chirality 16, 36–44 (2004). 9. Crettol, S. et al. Methadone enantiomer plasma levels CYP2B6, CYP2C19 and CYP2C9 genotypes, and response to treatment. Clin. Pharmacol. Ther. 78, 593–604 (2005). 10. McCance-Katz EF, Sullivan LE, Nallani S. Drug interactions of clinical

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Probit analysis of comparative assays on toxicities of lead chloride and lead acetate to in vitro cultured human umbilical cord blood lymphocytes

: 663–67. Tzimas G, Thiel R, Chahoud I, Nau H. (1997). The area under the concentration–time curve of all-trans-retinoic acid is the most suitable pharmacokinetic correlate to the embryotoxicity of this retinoid in the rat. Toxicol Appl Pharmacol 143 : 436–444. US Environmental Protection Agency (USEPA). (2001). EPA-902-B01-001: best management practices for lead at outdoor shooting ranges EPA-902-B01-001. United States Environmental Protection Agency Region 2. Wang X, Wang M, Dong W, Piao F, Li S. (2013). Subchronic exposure to lead acetate

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Antivirals for Virus Induced Exacerbations of Asthma and COPD Treatment

or chronic obstructive pulmonary disease. Ann. Allergy Asthma Immunol. 2001;87:447-454. 22. Hayden FG, Belshe RB, Clover RD, et al. Emergence and Apparent Transmission of Rimantadine-Resistant Influenza A Virus in Families. N. Engl. J. Med. 1989;321:1696-1702. 23. Davies B.E. Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations. J. Antimicrob. Chemother. 2010;65:ii5-ii10. 24. Jefferson T, Jones M, Doshi P, et al. Oseltamivir for influenza in adults and children: systematic review

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