Jānis Gardovskis, Ilze Štrumfa, Edvīns Miklaševičs, Arvīds Irmejs, Genādijs Trofimovičs, Egils Vjaters, Viktors Borošenko, Inga Melbārde-Gorkuša, Andris Gardovskis, Andrejs Vanags, Andris Ābele, Signe Subatniece, Marianna Bitiņa, Liāna Švampāne, Jekaterina Žestkova, Dace Bērziņa, Karina Aksenoka, Viesturs Boka, Aldis Puķītis, Aiga Stāka and Laima Tihomirova
patients with familial adenomatous polyposis (FAP). Human Mutation: Mutation in Brief , No. 705, http://www3.interscience.wiley.com/homepages/38515/pdf/mutation/705.pdf http://www3.interscience.wiley.com/homepages/38515/pdf/mutation/705.pdf
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Wei-Chieh Wu, Yi-Ru Chang, Yo-Liang Lai, An-Cheng Shiau, Ji-An Liang, Chun-Ru Chien, Yu-Cheng Kuo and Shang-Wen Chen
was approved by the local Institutional Review Board (CMUH106-REC3-119).
Patients were divided into two cohorts (60 for training, 30 for validation). In the training cohort, patients with gynecological (cervix or endometrium), rectal, or prostatecancer treated with pelvic irradiation by daily IGRT between January 2012 and January 2015 at China Medical University Hospital were included. The sample size for gynecological, rectal, and prostatecancers was 20 each. The patient-related parameters and BMFs were retrieved. Staging was based on the staging system (7 th
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Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO. Curcumin and kolaviron ameliorate di‐n‐butylphthalate‐induced testicular damage in rats. Basic Clin Pharmacol Toxicol 100
third-degree blood relative (on the same side of the family) diagnosed with breast and/or epithelial ovarian/fallopian tube/primary peritoneal cancer ≤50 years
Diagnosed at any age with ≥2 first-, second-, or third-degree blood relatives (on the same side of the family) with breast and/or epithelial ovarian/ fallopian tube/primary peritoneal cancer at any age
Diagnosed at any age with ≥2 first-, second-, or third-degree blood relatives (on the same side of the family) with pancreatic cancer or aggressive prostatecancer (Gleason score ≥7) at any age
Los Angeles County. Br J Cancer. 63, 963-966. https://doi.org/10.1038/bjc.1991.210 PMid:2069852 PMCid:PMC1972548
24. Watanabe, S., Koessel, S (1993). Colon cancer: an approach from molecular epidemiology. J Epidemiol. 3, 47-61. https://doi.org/10.2188/jea.3.47
25. Severson, R.K., Nomura, A.M., Grove, J.S., Stemmermann, G.N. (1989). A prospective study of demographics, diet, and prostatecancer among men of Japanese ancestry in Hawaii. Cancer Res. 49, 1857-1860. PMid:2924323
26. Anthony, M.S., Clarkson, T.B., Hughes, C.L.Jr., Morgan, T.M., Burke
Marco Giovanni Persico, Federica Eleonora Buroni, Francesca Pasi, Lorenzo Lodola, Carlo Aprile, Rosanna Nano and Marina Hodolic
patients with gliomas. 4 - 6 18 F-fluorodeoxyglucose ( 18 F-FDG) Positron Emission Tomography (PET) in brain tumours was the first application of this modality in oncology 7 , 8 , however because of the high physiologic glucose uptake of normal brain tissue, 18 F-FDG did not gain widespread use in brain tumours imaging. 9 , 10
PET imaging with [ 11 C]- and [ 18 F]-labelled choline derivates is frequently used in the staging and detection of recurrent prostatecancer disease due to the increased choline kinase expression in this malignancy. Moreover, choline kinase
Triazinopyrazolothieno pyrimidine derivatives 1–5 were evaluated for their anti-inflammatory, analgesic and anticancer activities and acute toxicity. Anti-inflammatory activity of the compounds was studied using the carrageenan test. All tested compounds showed analgesic activity, 3-methoxycarbonyl-4,6-dimethyl-8-[(N-methylindolyl)methyl] pyrimido [5′,4′:4,5]thieno [3′,2′-3,4]pyrazolo [5,1-c]triazine (4) showed activity comparable to that of diclofenac. Compounds 1–5 were also screened for anticancer activity on a human lung cancer cell line (A549) and a human prostate cancer cell line (DU145) using the MTT micro-cultured tetrazolium assay method. Compound 4 showed also significant anticancer activity against both cancer cell lines, comparable to that of doxorubicin. The most active compounds were tested for their acute toxicity and median lethal doses were evaluated.