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Prognostic role of diffusion weighted and dynamic contrast-enhanced MRI in loco-regionally advanced head and neck cancer treated with concomitant chemoradiotherapy

, motion correction algorithm was applied that allowed for pairwise in-plane (acquisition plane) rigid co-registration of all raw perfusion images of a given slice location with well-chosen reference image over time. Quantitative DCE-MRI parameters were volume transfer constant (K trans ), extracellular extravascular volume fraction (v e ) and plasma volume fraction (V p ). The pharmacokinetic modelling was done on a pixel-by-pixel basis using the extended Tofts model - a two compartment model, which is suitable for any freely diffusible tracer. The equation modelling

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Loose ends in the eradication of Helicobacter pylori infection

] low compliance, [ 4 ] and hypersecretion of hydrochloric acid. [ 5 ] However, the evidence is scarce for other factors, particularly the impact biotype, [ 6 ] smoking, [ 7 ] diabetes mellitus (DM), [ 8 ] and previous treatment failure. In particular, it is unknown whether the body mass index (BMI) influences in a clinically significant way the pharmacokinetics and/or pharmacodynamics of the drugs involved in eradication (in particular, the proton pump inhibitors and antibiotics). Furthermore, to date, studies are in most cases controlled in relation to the

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Safety and efficacy of doxorubicin-eluting superabsorbent polymer microspheres for the treatment of liver metastases from neuroendocrine tumours: preliminary results

10.1159/000329602 18 Varela M, Real M, Burrel M, Forner A, Sala M, Brunet M, et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol 2007; 46 : 474-81. 10.1016/j.jhep.2006.10.020 10.1016/j.jhep.2006.10.020 Varela M Real M Burrel M Forner A Sala M Brunet M Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics J Hepatol 2007 46 474 474 10.1016/j.jhep.2006.10.020 19 Vogl T, Lammer J

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Helicobacter pylori treatment results in Slovenia in the period 2013-2015 as a part of European Registry on Helicobacter pylori Management

inhibitors in the treatment of Helicobacter pylori infection. Aliment Pharmacol Ther 2012; 36 : 414-25. 10.1111/j.1365-2036.2012.05211.x McNicholl AG Linares PM Nyssen OP Calvet X Gisbert JP. Meta-analysis: esomeprazole or rabeprazole vs. first-generation pump inhibitors in the treatment of Helicobacter pylori infection Aliment Pharmacol Ther 2012 36 414 25 10.1111/j.1365-2036.2012.05211.x 16 Serrano D, Torrado S, Torrado-Santiago S, Gisbert J P. The influence of CYP2C19 genetic polymorphism on the pharmacokinetics/-pharmacodynamics of proton pump inhibitor

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Lipodystrophy HIV-related and FGF21: A new marker to follow the progression of lipodystrophy?

Complete Lipodystrophy and Insulin-Resistant Diabetes Physiol Res 2014 4 63 483 90 22 Gaich G, Chien JY, Fu H, Glass LC, Deeg MA, Holland WL, et al . The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab 2013;18: 333–40. 10.1016/j.cmet.2013.08.005 Gaich G Chien JY Fu H Glass LC Deeg MA Holland WL et al The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes Cell Metab 2013 18 333 40 23 Dong JQ, Rossulek M, Somayaji VR, Baltrukonis D, Liang Y, Hudson K, et al . Pharmacokinetics and

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Progress and current status of influenza researches in China

hemagglutinin Cell Host Microbe 2017 22 471 – 83 21 Kadam RU, Juraszek J, Brandenburg B, Buyck C, Schepens WBG, Kesteleyn B, et al Potent peptidic fusion inhibitors of influenza virus. Science 2017; 358: 496–502. Kadam RU Juraszek J Brandenburg B Buyck C Schepens WBG Kesteleyn B et al Potent peptidic fusion inhibitors of influenza virus Science 2017 358 496 – 502 22 Koshimichi H, Ishibashi T, Kawaguchi N, Sato C, Kawasaki A, Wajima T. Safety, tolerability, and pharmacokinetics of the novel anti-influenza agent baloxavir

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Viral hepatitis in hemodialysis: An update

standard of care and emerging direct-acting antiviral agents. J Viral Hepat 2012;19:449-64. 166. Peck-Radosavljevic M, Boletis J, Besisik F, Ferraz ML, Alric L, Samuel D, et al. Low-dose peginterferon alfa-2a (40KD) is safe and produces a SVR in patients with chronic hepatitis C and end-stage renal disease. Clin Gastroenterol Hepatol 2011;9:242-8. 167. Glue P, Fang JW, Rouzier-Panis R, Raffanel C, Sabo R, Gupta SK, et al. Pegylated interferon-alpha2b: Pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy data. Hepatitis C

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Is there a role for contrast-enhanced ultrasound in the detection and biopsy of MRI only visible breast lesions?

. Pharmacokinetic analysis of malignant pleural mesothelioma-initial results of tumor microcirculation and its correlation to microvessel density (CD-34). Acad Radiol 2008; 15 : 563-70. 10.1016/j.acra.2007.12.014 Giesel FL Choyke PL Mehndiratta A Zechmann CM von Tengg-Kobligk H Kayser K. Pharmacokinetic analysis of malignant pleural mesothelioma-initial results of tumor microcirculation and its correlation to microvessel density (CD-34) Acad Radiol 2008 15 563 70 10.1016/j.acra.2007.12.014 14 Knopp MV, Weiss E, Sinn HP, Mattern J, Junkermann H, Radeleff J, et al

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Optimal use of corticosteroids in nephrology

. Bergmann TK, Barraclough KA, Lee KJ, Staatz CE. Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation. Clin Pharmacokinet 2012;51:711-41. 83. Meier-Kriesche HU, Baliga R, Kaplan B. Decreased renal function is a strong risk factor for cardiovascular death after renal transplantation. Transplantation 2003;75:1291-5. 84. Pascual J, van Hooff JP, Salmela K, Lang P, Rigotti P, Budde K. Three-year observational follow-up of a multicenter, randomized trial on tacrolimus-based therapy with

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Interventional Treatment of Cardiac Emergencies in Children with Congenital Heart Diseases

.1016/j.jcin.2015.05.027. 61. Sivakumar K, Bhagyavathy A, Coelho R, et al. Longevity of neonatal ductal stenting for congenital heart diseases with duct-dependent pulmonary circulation. Congenit Heart Dis. 2012;7:526-533. doi: 10.1111/j.1747-0803.2012.00657.x. 62. Amoozgar H, Cheriki S, Borzoee M, et al. Short-term result of ductus arteriosus stent implantation compared with surgically created shunts. Pediatr Cardiol. 2012;33:1288-1294. 63. Lee K, Seto W, Benson L, et al. Pharmacokinetics of sirolimus-eluting stents implanted in the neonatal arterial

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