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Diagnostic accuracy of three biomarkers in identifying serious bacterial infections in children younger than 36 months with fever without source / Acurateţea diagnostică a trei biomarkeri în identificarea infecţiilor bacteriene severe la copiii cu vârsta sub 36 luni cu febră fără focar

Abstract

Objectives: Our study aimed to evaluate and compare the accuracy of C-reactive protein, Procalcitonin and Interleukine-6 in identifying serious bacterial infections (SBI) in children with fever without source.

Methods: 139 children, aged 7 days to 36 months, addressing the Emergency Department from a Romanian university hospital, were prospectively enrolled during 2013. C-reactive protein, Procalcitonin and Interleukin-6 were determined for every patient. SBI diagnosis was based on cultures results and chest radiographs.

Results: 31 patients (22.3%) had SBI. C-reactive protein [AUC: 0.87 (95%CI: 0.81-0.92)] and Procalcitonin [AUC: 0.83 (95%CI: 0.76-0.89)] proved strong prediction value for SBI and performed better than Interleukin-6 [AUC: 0.77 (95%CI: 0.69-0.84)]. For the group of children with the duration of fever less than 8 hours, Interleukin- 6 was the best predictor [AUC: 0.88 (0.76-0.95)].

Conclusions: Both C-reactive protein and Procalcitonin are strong and similar predictors for SBI, and Interleukin- 6 might be a better SBI screening tool for children with shorter duration of fever.

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History of internal radiation exposure in a wild masked palm civet (Paguma larvata) at Fukushima assessed by autoradiography of vibrissae

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CYHV-3 Infection Dynamics in Common Carp (Cyprinus Carpio) – Evaluation of Diagnostic Methods

. Beevers N., Way K., Le Duff R.M., Martin P., Joiner C.: Reactivation of koi carp herpesvirus infections in common carp Cyprinus carpio. Dis Aquat Organisms 2005, 67, 15-23. 10. St. Hilarie S., Beevers N., Joiner C., Wood G., Dunn P., Way K.: Development of a serological tool for koi herpesvirus surveillance. Proceedings of EAFP 13th International Conference. Grado, Italy, 2007.

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Eosinophil activation markers in clonal and non-clonal eosinophilia

Abstract

Eosinophils are leukocytes with multiple functions in physiologic and pathologic circumstances. Eosinophilia is typically associated with reactive conditions (helmintic infections, allergic or drug reactions and atopic disorders) and sometimes with hematologic and non- hematologic malignancies. Evaluation of a patient with eosinophilia requires numerous imaging investigations and laboratory tests for establishing the right treatment. We measured the degree of eosinophilic activation using serologic biomarkers such as serum eosinophil cationic protein (ECP) , interleukin-5 (IL-5) and eosinophilic cationic protein/eosinophil count (ECP/Eo) ratio in order to differentiate earlier among distinct eosinophilic conditions: clonal, non-clonal with malignancy and reactive eosinophilia with inflammation. The median ECP value in eosinophilic patients was significantly higher when compared to that of the control group (19.55 vs. 4.93 ng/mL, p<0.05). Within patients with eosinophilia, the clonal eosinophilia group showed a significantly higher median ECP value compared to the median ECP values of the non-clonal eosinophilia groups - (30.15 vs. 19.5 ng/mL, p<0.05 and respectively 30.15 vs. 13.3 ng/mL, p<0.05). Also patients having non-clonal eosinophilia with malignancy had a significantly higher median ECP value compared to those of reactive eosinophilia and inflammation (19.5 vs. 13.3 ng/mL, p<0.05). While ECP serum levels seemed to be a discriminatory tool for different groups of eosinophilic patients IL-5 and ECP/Eo were less useful for this purpose. However our results must be confirmed in larger studies

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Letter to the Editor: Serum fibronectin and C-reactive protein in prediction of preterm delivery

and Term La bor, Life Sci J, 2013, 10(6s):368-371. 4. Cunningham G, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY. Pretem birth. In Twickler DM, Wendel GD. Williams Obstetrics 23rd Edition. Mc Graw Hil Medical, USA. 2010, 804-32. 5. Di Renzo GC, Roura LC, Facchinetti F, Antsaklis A, Breborowicz G, Gratacos E et al. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal

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Potential role of beavers (Castor fiber) in contamination of water in the Masurian Lake District (north-eastern Poland) with protozoan parasites Cryptosporidium spp. and Giardia duodenalis

.: Prevalence and age-related variation of Cryptosporidium species and genotypes in dairy calves. Vet Parasitol 2004, 122, 103-117. 20. Schets F.M., van Wijnen J.H., Schijven J.F., Schoon H., de Roda Husman A.M.: Monitoring of waterborne pathogens in surface waters in Amsterdam, the Netherlands, and the potential health risk associated with exposure to Cryptosporidium and Giardia in these waters. Appl Environ Microbiol 2008, 74, 2069-2078. 21. Smith H.V., Caccio S.M., Tait A., McLauchlin J., Thompson R.C.: Tools for investigating the

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Use of Silver Nitrate for the Assessment of Sperm Measurements in Selected Farm and Free-Living Animal Species

Angelis P., Claussen O.P.: Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod 1999, 14, 1039-1049. 11. Guzick D.S., Overstreet J.W., Factor-Litvak P., Brazil C.K., Nakajima S.T., Coutifarls C., Carson S.A., Cisneros P., Steinkampf M.P., Hill J.A., Xu D., Vogel D.L.: Sperm morphology, motility, and concentration in fertile and infertile men. N Eng J Med 2001, 345, 1388-1393. 12. Henkel R., Schreiber G., Sturmhoefel A., Hipler U.C., Zermann D.H., Menkveld R.: Comparison of three staining methods

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Seroprevalence of Coxiella burnetii in Polish cattle herds

-Badora J., Mackiewicz B., Dutkiewicz J.: Prevalence of antibodies to Coxiella burnetii among farming population in eastern Poland. Ann Agric Environ Med 2003, 10, 265-267. 5. Cygan Z., Buczek J., Modzelewska A., Guzik Z.: Q fever diagnosed serologically in herd of dairy cows. Med Weter 1983, 39, 536-538. 6. Czaplicki G., Houtain J-Y., Mullender C., Manteca C., Saegerman C.: Bulk tank milk, reliable tool for diagnosing Q fever? Epidemiol Santeï Anim 2009, 56, 117-127. 7. Frangoulidis D., Walter M.C., Antwerpen M., Zimmermann

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Assessment of preoperative and postoperative prealbumin in thoracic surgery – a two months experience in a Romanian university hospital / Evaluarea preoperatorie şi postoperatorie a prealbuminei în chirurgia toracică - experiența de 2 luni a unui spital universitar din România

in adult patients receiving enteral nutrition in an urban medical center. JPEN J Parenter Enteral Nutr. 2012 Mar;36(2):197-204. DOI: 10.1177/0148607111413896 35. Sharma A, Giraddi G, Krishnan G, Shahi AK. Efficacy of Serum Prealbumin and CRP Levels as Monitoring Tools for Patients with Fascial Space Infections of Odontogenic Origin: A Clinicobiochemical Study. J Maxillofac Oral Surg. 2014 Mar;13(1):1-9. DOI: 10.1007/s12663-012-0376-4 36. Bernstein LH. The systemic inflammatory response syndrome C-reactive protein and transthyretin

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Optimisation and comparison of three PCR procedures for molecular identification of Taenia solium

.M., Montero E., Puente Lopez-Velez R., Hernandez M., Sciutto E., Harrison L.J.S., Parkhouse R.M.E., Garate T.: PCR tools for the differential diagnosis of Taenia saginata and Taenia solium taeniasis/cysticercosis from different geographical locations. Diagn Microbiol Infect Dis 2002, 42, 243-249. 7. Harrington A.T., Creutzfeldt C.J., SenGupta D.J., Hoogestraat D.R., Zunt J.R., Cookson B.T.: Diagnosis of neurocysticercosis by detection of Taenia solium DNA using a global DNA screening platform. Clin Infect Dis 2009, 48, 86-90. 8. Jardim

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