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Kelemen Hajnal, Hancu Gabriel, Rusu Aura, Varga Erzsébet and Székely Szentmiklósi Blanka

combination with polymeric nanoparticle delivery platforms for enhanced antitumor efficacy. Angew Chem Int Ed. 2014;53(43):11532-11537. 39. Lang BC, Yang J, Wang Y, et al. An improved design of water-soluble propofol prodrugs characterized by rapid onset of action. Anesth Analg. 2014;118(4):745-754. 40. Wozniak KM, Vornov JJ, Mistry BM. Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers. J Transl Med. 2015;13:170. 41. Sharma SK, Bagshawe KD. Antibody-directed enzyme prodrug therapy

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Marcin Wrzosek

., Accatino A., Priano L., Neiger-Aeschbacher G., Cizinauskas S., Jaggy A.: Quantitative electroencephalographic findings in beagles anaesthetized with propofol. Vet J 2003, 166, 58–66. 5. Berger H.: Über das Elektrenkephalogramm des Menschen. Arch Psychiatr Nervenkr 1929, 87, 527–570. 6. Brauer C., Kastner S.B., Rohn K., Schenk H.C., Tunsmeyer J., Tipold A.: Electroencephalographic recordings in dogs suffering from idiopathic and symptomatic epilepsy: diagnostic value of interictal short time EEG protocols supplemented by two activation techniques. Vet J 2012

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A A Skutchanova and B Saniova

G8BQAJK 5. Chalmers DJ. Solving the “Hard Problem”. Scientific American 286(4) 90-99 (April 2002) 6. Tononi G, Koch C. The Neual Corelates of Consciousnes. Ann. N.Y. Acad. Sci. 2008;1124:239 – 261. 7. Sarasso S, Boly M. Consciousness and Complexity during Unresponsiveness Induced by Propofol, Xenon, and Ketamine. Volume 25, Issue 23, p3099–3105, 7 December 2015 8. Ambler Z. et al. Základy neurologie. Praha: Galén, 2011. 351 p ISBN 9788072627073 9. Doušek F. Hejno bez ptáků. Toito 2012. ISBN 978-80-260-3077-5 10. Chalmers DJ

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Amjad Hussain, Muhammad Ali Syed, Nasir Abbas, Sana Hanif, Muhammad Sohail Arshad, Nadeem Irfan Bukhari, Khalid Hussain, Muhammad Akhlaq and Zeeshan Ahmad

, Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective, randomized, double-blind, vehicle-controlled, dose-finding study in Japanese adult surgical patients, Clin. Ther. 27 (2005) 588–593; 10.1016/j.clinthera.2005.05.003. 10. P.-L. Lin, S.-Z. Fan, C.-H. Huang, H.-H. Huang, M.-C. Tsai, C.-J. Lin and W.-Z. Sun, Analgesic effect of lidocaine patch 5 % in the treatment of acute herpes zoster: a double-blind and vehicle-controlled study, Region. Anesth. Pain M. 33 (2008) 320–325. 11. L

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Ľudovít Mušák, Erika Halašová, Tatiana Matáková, Lucia Letková, Ludmila Vodičková, Janka Buchancová, Henrieta Hudečková, Oto Osina, Pavel Souček and Pavel Vodička

humans. Some pharmaceutical drugs. Lyon, International Agency for Research on Cancer   66 : 87pp. Jaloszynski P, Kujawski M, Wasowicz M, Szulc R and Szyfter K. (1999). Genotoxicity of inhalation anesthetics halothane and isoflurane in human lymphocytes studied in vitro using the comet assay. Mutat Res   439 : 199-206. Karahalil B, Yagar S, Bahadir G, Durak P and Sardas S. (2005). Diazepam and propofol used as anesthetics during open-heart surgery do not cause chromosomal aberrations in peripheral blood lymphocytes

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Vladimir Ajdžanović, Ivan Spasojević, Jasmina Pantelić, Branka Šošić-Jurjević, Branko Filipović, Verica Milošević and Walter Severs

. J Chem Inf Model 2005; 45: 1680-5. Lucks BC. Vitex agnus-castus essential oil and menopausal balance: a research update. Complement Ther Nurs Midwifery 2003; 9: 157-60. Bahri MA, Heyne BJ, Hans P, Seret AE, Mouithys-Mickalad AA, Hoebeke MD. Quantification of lipid bilayer effective microviscosity and fluidity effect induced by propofol. Biophys Chem 2005; 114: 53-61. Cooper P, Kudynska J, Buckmaster HA, Kudynski R. An EPR investigation of spin-labelled erythrocytes as a diagnostic

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Arnis Vilks, Santa Rasa, Simona Doniņa, Modra Murovska and Biruta Mamaja

not by propofol: Mediating mechanisms and prophylactic measures. Anesth. Analg., 97, 1331-1339. Mussi, C., Angelini, C., Crippa, S., Caprotti, R., Fumagalli, L., Motta, V., Uggeri, F. (2003). Alteration of hypothalamus-pituitary-adrenal glands axis in colorectal cancer patients. Hepatogastroenterology, 50 Suppl. 2, ccxxviii-ccxxxi. O’Riain, S. C., Buggy, D. J., Kerin, M. J., Watson, R. W., Moriarty, D. C. (2005). Inhibition of the stress response to breast cancer surgery by regional anesthesia and analgesia does not affect vascular

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Massimiliano Sorbello, Ivana Zdravkovic, Rita Cataldo and Ida Di Giacinto

stenosis with resultant stridor. J Laryngol Otol 2012; 126: 751-755. doi: 10.1017/S0022215112000795 19. Goldmann K, Kuhlmann S, Gerlach M, Bornträger C. Removal of the laryngeal mask airway in the post-anesthesia care unit. A means of process optimization?. Anaesthesist 2011; 60: 1002-1008. doi: 10.1007/s00101-011-1936-6 20. Ashay NA, Wasim S, Anil TB. Propofol requirement for insertion of I-gel versus laryngeal mask airway: A comparative dose finding study using Dixon’s up-and-down method. J Anaesthesiol Clin Pharmacol 2015; 31: 324

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Miroslav Pohanka

, Wilfi nger G and Metzler H. (2012). Eff ect of sugammadex or neostigmine neuromuscular block reversal on bispectral index monitoring of propofol/ remifentanil anaesthesia. Br J Anaesth 108: 602-606. Darreh-Shori T and Soininen H. (2010). Eff ects of cholinesterase inhibitors on the activities and protein levels of cholinesterases in the cerebrospinal fluid of patients with Alzheimer’s disease: a review of recent clinical studies. Curr Alzheimer Res 7: 67-73. de Oliveira P, Gomes AQ, Pacheco TR, de Almeida VV, Saldanha C

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Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Sonia Elena Popovici, Adriana Mariana Sas, Adrian Tudor Stan, Emil Robert Stoicescu and Dorel Sandesc

critically ill patients receiving target temperature management following cardiac arrest. Resuscitation. 2016;107:107-114. doi: 10.1016/j.resuscitation.2016.07.239. 4. Yao X, Carlson D, Sun Y, et al. Mitochondrial ROS induces cardiac inflammation via a pathway through mtDNA damage in a pneumonia-related sepsis model. PLoS One. 2015;10:1-28. doi: 10.1371/journal.pone.0139416. 5. Tao X, Lu L, Xu Q, Li S, Lin M. Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane. J Zhejiang Univ Sci B. 2009