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Vichit Supornsilchai, Yodporn Hiranras, Chansuda Bongsebandhu-phubhakdi and Suttipong Wacharasindhu

, Chang YL, Jou ST, Tseng YT, Lee YC. Treatment of mediastinal immature teratoma in a child with precocious puberty and Klinefelter’s syndrome. Ann Thorac Surg. 2006; 82:1906-8. 13. Poomthavorn P, Khlairit P, Mahachoklertwattana P. Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for diagnosing precocious puberty. Horm Res. 2009; 72:114-9. 14. Egli CA, Rosenthal SM, Grumbach MM, Montalvo JM, Gondos B. Pituitary gonadotrophin independent male limited autosomal dominant sexual precocity in nine generations: ‘Familial

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Xu Zeng, Naesinee Chaiear, Piyanee Klainin, Jiraporn Khiewyoo, David Koh, Peter Wong Horng Hien and Siu Yin Lee

. 17. Cronbach LJ, Meehl PE. Construct validity in psychological tests. Psychological Bulletin 1955; 52: 281-302. [cited 2010 May 12]. Available from: http://psychclassics.yorku.ca/Cronbach/construct.htm 18. Schunemann HJ, Sperati F, Barba M, Santesso N, Melegari C, Akl EA, Guyatt G, Muti P. An instrument to assess quality of life in relation to nutrition: item generation, item reduction and initial validation. Health and Quality of Llife Outcomes.2010; 26:1-13. 19. Bergk J, Flammer E, Steinert T. Coercion Experience Scale (CES

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Kittiphop Somboonnithiphol, Ouyporn Panamonta, Pakaphan Kiatchoosakun, Junya Jirapradittha, Manat Panamonta, Pagakrong Lumbiganon and Pichet Somsapt

Abstract

Background: Salt wasting 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH) is the most common cause of adrenal insufficiency during neonatal periods. Newborn screening for CAH will improve case early detection and decrease associated morbidity and mortality. The previous nationwide incidence of CAH in 1999 was 1:19,521. To date, CAH newborn screening has not been included in national newborn screening program.

Objective: We evaluated the incidence of CAH in newborns delivered at Srinagarind Hospital.

Methods: Between September 2005 and June 2008, the filter paper blood spot 17-hydroxyprogesterone (17-OHP) tests were determined in newborns delivered at Srinagarind Hospital. The tests were concurrently performed with TSH and phenylketonuria screening in national newborn screening program of the Ministry of Public Health of Thailand. Re-evaluation with completed physical examinations, repeated blood test for serum 17-OHP and serum electrolytes were performed in newborns who had 17-OHP levels higher than cut-off values. CAH was indicated in patients who had abnormal high serum 17-OHP concentration with or without hyperpigmentation and/or ambiguous genitalia in affected females and/or electrolyte imbalance.

Results: Five thousand seven hundred seventy one of 7,147 (80.74%) live births were screened for CAH. Fourteen infants (0.24%) were recalled for re-evaluation. Eight of fourteen (57.14% response rate) infants had the repeated blood tests. Abnormal elevated serum 17-OHP concentrations were found in two infants. Only one had clinical and laboratory findings indicative of CAH. The incidence of CAH was therefore 1:5,771.

Conclusion: The incidence of CAH from newborn screening in Srinagarind Hospital was obviously higher than national incidence of Thailand. The implement of CAH screening for all neonates should be reconsidered.

Open access

Shan Huang, Wenfang Peng, Wensui Zhao, Bin Sun and Xiaohong Jiang

Abstract

Background: Impaired Glucose Regulation (IGR) is a term that refers to blood glucose levels that are higher than the normal range, but lower than Type 2 diabetes mellitus (T2DM).

Objective:We aimed to test the role of plasma adiponectin (APN) and plasma C-reactive protein (CRP) in predicting the risk of cardiovascular disease in patients with different degrees of impaired glucose regulation (IGR).

Methods: A total of 210 outpatients for physical examination were divided into 4 groups: 42 cases of normal glucose tolerance (NGT), 36 cases of impaired fasting glucose (IFG), 92 cases of impaired glucose tolerance (IGT) and 40 cases of IFG+IGT. Body mass index (BMI), blood pressure, lipids, insulin resistance (homeostasis model assessment, HOMA-IR), APN, CRP and carotid intima-media thickness (CIMT) were measured.

Results: In IGT and IFG+ IGT groups, CIMT and CRP were significantly higher, whereas APN was significantly lower compared with IFG and NGT groups (p < 0.05). BMI and HOMA-IR were significantly higher in IGR patients compared with control subjects (p < 0.05). CIMT was positively related to CRP and HOMA-IR and negatively to APN (p < 0.05). Multiple stepwise regression analysis using CIMT as a dependent variable showed that APN and 2hPG were independently risk factors associated with CIMT.

Conclusion: Increased CIMT in prediabetes state may in part be explained by lower plasma adiponectin and higher C-reactive protein levels.

Open access

Supharat Jariyakosol, Pear Pongsachareonnont and Supapan Sitthanon

, Yamauchi Y, Minoda H, Usui N, Iwasaki T, et al. Progressive outer retinal necrosis caused by herpes simplex virus type 1 in a patient with acquired immunodeficiency syndrome. Ophthalmology. 2000; 107:790-4. 15. Thompson PP, Kowalski RP. A 13-year retrospective review of polymerase chain reaction testing for infectious agents from ocular samples. Ophthalmology. 2011; 118:1449-53. 16. Yeung SN, Butler A, Mackenzie PJ. Applications of the polymerase chain reaction in clinical ophthalmology. Can J Ophthalmol. 2009; 44:23-30. 17

Open access

Muhammad Afzal and Sajid Malik

Abstract

Background: Longitudinal deficiency of upper limbs with oligodactyly is a very rare congenital malformation. It manifests itself as preaxial or postaxial hypoplasia/aplasia of long bones accompanied by reduction of palm and phalanges.

Objective: To report two cases with essentially similar phenotypic presentation characterized by unilateral mesomelic shortening of limb, ulnar hypoplasia, and severe deficiency of skeletal elements of hand that were found in unrelated individuals.

Methods: Review of clinical and family history, phenotypic examination, physical and radiological investigations, and literature review.

Results: In both individuals, the right arm was short, the size of the middle arm and hand being dramatically reduced in size, and the hand comprising only two functional digits. Roentgenograms revealed hemimelia/ dysmelia of the ulna, hypoplasia of radius, dysplastic distal radial head, and several missing carpals. Only two phalangeal rays were witnessed in the hand. Radiographic measurements showed a normal contralateral arm and lower limbs, and no other associated symptoms. These phenotypes were classified as type I and type D according to the schemes proposed by Swanson et al., and Ogino and Kato, respectively. Both individuals were the product of third degree consanguineous unions (F = 0.0625).

Conclusion: Consistent phenotypic pattern of longitudinal limb anomalies evident in two independent subjects suggest a common underlying genetic etiology. There is currently no known genetic factor to allow molecular testing and risk estimation for family members. Isolated limb anomalies may provide important clues to understand pathomorphogenetic mechanisms that lead to the disruption of normal limb development.

Open access

Jittida Shoosanglertwijit, Sanae Kaewnopparat, Benjawan Yongmaitreesakul, Sarinthip Pattayananthavej and Nattha Kaewnopparat

& Sons, 1986; p. 474-7. 8. Bundgaard H, Norgaard T, Nielson NM. Photodegradation and hydrolysis of furosemide and furosemide esters in aqueous solutions. Int J Pharm. 1988; 42:217-24. 9. Long PF. Microbiological tests on oral pediatric medicines - requirements for an improved Pharmacopoeia monograph. Ann Pharmacother. 2006; 40:158-9. 10. The United States Pharmacopeia 30 / National Formulary 25. Asian edition. Rockville:The United States Pharmaceutical Convention Inc, 2007; p. 1, 83-9, 585-8.

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Effat Hatefnia, Kobra Alizadeh and Mostafa Ghorbani

of hypertension, childbirth experience, number of children, menopause, and engaging in regular physical activity). The second part comprised 10 questions to assess participants’ knowledge (e.g., “whether hypertension is preventable”) providing a score ranging from 0 to 10. Scoring questions related to knowledge assessment was achieved through a binary scale (a score of 0 being for “I do not know” and wrong answers, and a score 1 for correct answers). Knowledge was assessed in a regression model using a t test. The third part comprised questions on constructs of

Open access

Sunee Suwanpasu, Yupin Aungsuroch and Chanokporn Jitapanya

overcome psychological barriers to physical activity: a discussion paper. Int J Nurs Stud. 2008; 45:1690-9. 24. Resnick B, Orwig D, Yu-Yahiro J, Hawkes W, Shardell M, Hebel JR, et al. Testing the effectiveness of the exercise plus program in older women post-hip fracture. Ann Behav Med. 2007; 34:67-76. 25. Orwig DL, Hochberg M, Yu-Yahiro J, Resnick B, Hawkes WG, Shardell M, et al. Delivery and outcomes of a yearlong home exercise program after hip fracture: a randomized controlled trial. Arch Intern Med. 2011; 171

Open access

Phantipa Sakthong, Vijj Kasemsup and Win Winit-Watjana

.74 0.10–1.00 0 43.0    EQ-VAS 0.84 0.13 0.80 0.50–1.00 0 23.3 Table 3 Comparison of 8 domains and 2 summary scores of SF-12v2 between the Thai sample and the US general population [ref. 9] Domain/summary component Thai sample after heart surgery U.S. general population Difference (Thai – US) Physical functioning 80.96 ± 24.38 81.18 ± 29.10 −0.22 Role physical 70.01 ± 25.10 80.53 ± 27.13 −10.52 P < 0.01 (one-sample t test) Bodily pain 79.40 ± 21.92 81.74 ± 24.53 −2.34 P