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Adenosine pretreatment attenuates angiotensin II-mediated p38 MAPK activation in a protein kinase A dependent manner

in vascular smooth muscle cells. Regulatory Peptides. 2008; 147: 37-44. 11. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S. Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Clinical Science. 2007; 112:417-28. 12. Das UN. Is angiotensin-II an endogenous proinflammatory molecule? Med Sci Monit. 2005; 11: RA155-162. 13. Mogi M, Iwai M, Horiuchi M. Emerging concepts of regulation of angiotensin II receptors, new players and targets for traditional

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Original article. Transcription factors regulate Forkhead box O1 gene promoter activity in pancreatic β-cells

References 1. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest. 2002; 110: 1839-47. 2. Sussel L, Kalamaras J, Hartigan OCDJ, Meneses JJ, Pedersen RA, Rubenstein JL, et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998; 125:2213-21. 3. Sander M, Sussel L, Conners

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Effects of daidzein on testosterone secretion in cultured immature mouse testis

impact Leydig cell differentiation. Biol Reprod. 2010; 83: 488-501. 11. Cherradi N, Rossier MF, Vallotton MB, Timberg R, Friedberg I, Orly J, et al. Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome P450scc and 3β-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. J Biol Chem. 1997; 272: 7899-907. 12. Stocco DM. Recent advances in the role of StAR. Rev Reprod. 1998; 3:82-5. 13. Walsh

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Comparison of methods for deriving neural progenitor cells from nonhuman primate embryonic stem cells

essential regulatory role in maintaining an undifferentiated state, proliferation, and suppresses astrocyte differentiation [ 16 , 47 ]. TLX expression knockout dramatically reduced the neural stem cell population, but increased GFAP staining and extended GFAP processes in the subventricular zone [ 3 ]. This finding suggested that NPCs derived by feeder-free methods may have a higher tendency toward an astrocytic lineage with lower expression of TLX and high expression of GFAP Both methods of NPC derivation can produce NPCs with similar characteristics including the

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Brief communication (Original). Trefoil factor expression by immunohistochemistry in patients with oral lichen planus

- Gomez G, Gil-Montoya JA, Bascones-Martinez A. Significance of liquefaction degeneration in oral lichen planus: a study of its relationship with apoptosis and cell cycle arrest markers. Clin Exp Dermatol. 2007; 32:556-63. 21. Hirota M, Ito T, Okudela K, Kawabe R, Yazawa T, Hayashi H, et al. Cell proliferation activity and expression of cell cycle regulatory proteins in oral lichen planus. J Oral Pathol Med. 2002; 31:204-12. 22. van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus

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Elisa Method For Serum Hepcidin Quantification In Bulgarian Population

erythropoietin therapy in renal disease. - Kidney Int., 75, 2009, 976-981. 5. Busbridge , M. et al. Development of a novel immunoassay for the iron regulatory peptide hepcidin. - Br. J. Biomed. Sci., 66, 2009, 150-157. 6. De Domenico , I. et al. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. - Mol. Biol. Cell., 18, 2007, 2569-2578. 7. Donovan , A. et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. - Cell. Metab., 1, 2005, 191-200. 8. Fleming , R. E. et W. S

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Acute cadmium exposure augments MMP-9 secretion and disturbs MMP-9/TIMP-1 balance

, Huang S. Cadmium activates the mitogen activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free Radic Biol Med. 2008; 45:1035-44. 25. Galan A, Garcia-Bermejo ML, Troyano A, Vilaboa NE, De Blas E, Kazanietz MG, et al. Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium induced apoptosis in human promonocytic cells. J Biol Chem. 2000; 275:11418-24. 26. Hyun JS, Satsu H, Shimizu M. Cadmium induces interleukin-8

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Immunotherapeutic efficacy of a Lactobacillus casei lysate as an adjuvant combined with a heated-4T1 mammary carcinoma cell lysate in a murine model of breast cancer

-cell lysate alone. However, with the exception of IL-2, no significant changes in cytokine levels were found after immunization with the L. casei lysate alone. L. casei can induce apoptosis in a colorectal cancer cells in vitro [ 3 ]. In vivo the antitumor effects of L. casei on colorectal cancer are mediated by modulation of regulatory T-cells towards a Th 17 -biased immune response [ 31 ]. These findings are consistent with the increased secretion of IL-17 seen following immunization with the combined vaccine in the present study. The antitumor efficacy of

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Grape seed proanthocyanidin extract ameliorates albuminuria and renal sclerosis in experimental diabetic nephropathy rats

, Numakami K, Saruta T, Itoh H. Glucose loading induces DNA fragmentation in rat proximal tubular cells. Metabolism. 1996; 45: 1348-53. 30. Ortiz A, Ziyadeh FN, Neilson EG. Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys. J Investig Med. 1997; 45:50-6. 31. Lee EY, Lee MY, Hong SW, Chung CH, Hong SY. Blockade of oxidative stress by vitamin C ameliorates albuminuria and renal sclerosis in experimental diabetic rats. Yonsi Med J. 2007; 48

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Downregulation in the mRNA expression of nuclear hormone receptor liver-X-receptor alpha (LXR-α) by TNF-α is abolished by the antioxidant kaempferol, but not ascorbic acid, in human hepatocarcinoma HepG2 cells

, Grunfeld C, Feingold KR. Downregulation of liver X receptor-α in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines. J Lipid Res. 2005; 46:2377-87. 10. Ng DL, Tie SW, Ong PC, Lim WS, Tengku-Muhammad TS, Choo, QC, Chew CH. Rapamycin pre-treatment abrogates Tumour Necrosis Factor-α down-regulatory effects on LXR-α and PXR mRNA expression via inhibition of c-Jun N-terminal kinase 1 activation in HepG2 cells [Internet]. Electron J Biotechn. 2011; 14. Available from

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