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Galileo in Bethesda: The future of gene editing

Conference on Recombinant DNA Research, led by Paul Berg. The conference identified potential risks and decided on steps to prevent them. The practical guidelines agreed upon at the 1975 Asilomar meeting have been eminently successful in launching quality rDNA scientific research while avoiding the promulgation of dangerous genetically modified organisms or their products. To my knowledge, there have been no instances of any biologically significant problems associated with the development and implementation of this recombinant DNA technology. If the future of

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Corticosteroids, the oldest agent in the prevention of chemotherapy-induced nausea and vomiting: What about the guidelines?

Introduction Chemotherapy-induced nausea and vomiting (CINV) has always been considered one of the most disturbing side effects of chemotherapy by cancer patients. [ 1 ] The negative impact on their quality of life is not to be underestimated. [ 2 ] However, in a time period of about two decades the number of patients reporting these bothersome side effects has markedly decreased. [ 3 ] Better control of side effects has been the result of several steps: a better understanding of the underlying pathophysiologic mechanisms of CINV, the introduction of

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Endoscopic diagnosis and treatment of precancerous colorectal lesions in patients with inflammatory bowel disease: How does the latest SCENIC international consensus intersect with our clinical practice?

’s quality of life. Currently, it is advocated that if the cancerous lesion is limited to the mucosa or invades the submucosal layer ≤ 1000 μm (SM1), the risk of lymph node metastasis is lower and most patients are eligible for endoscopic resection. While regular follow-up examination after endoscopic resection is mandatory, there is no consensus on the interval for follow-ups. Generally, the interval should be shorter than as for average patients ( e.g ., 3-6 months). For cancerous lesions that invade the submucosal layer > 1000 μm, with no clear-demarcated boundaries, or

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One Year Follow-up Results after Sleeve Gastrectomy in Type 2 Diabetes Mellitus Patients with Morbid Obesity

M, Pomp A. Early experience with two-stage laparoscopic Roux-en-Y gastric bypass as an alternative in the super-super obese patient. Obes Surg 13: 861–864, 2003. 17. D’Hondt M, Vanneste S, Pottel H et al. Laparoscopic sleeve gastrectomy as a single-stage procedure for the treatment of morbid obesity and the resulting quality of life, resolution of comorbidities, food tolerance, and 6-year weight loss. Surg Endosc 25: 2498–2504, 2011. 18. Chopra A, Chao E, Etkin Y, Merklinger L, Lieb J, Delany H. Laparoscopic sleeve gastrectomy for obesity: Can

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Early detection of liver damage in Mexican patients with chronic liver disease

-resources hinders the plausibility to detect liver disease with high-cost methodologies. Given the active alcoholism of the Mexican population, the low screening rate of HCV and HBV infection, and the excess weight factor in more than 70% of the adults, the number of cases of chronic liver damage and LC may increase shortly. Therefore, the early recognition of liver damage is necessary to establish prevention strategies, avoid the progression of fibrosis and improve the quality of life in these patients. This scenario provides the opportunity to establish preventive and

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Hepatic encephalopathy in patients in Lviv (Ukraine)

steatosis to cirrhosis. Hepatology 2006; 43: S99–112. Farrell GC Larter CZ Nonalcoholic fatty liver disease: from steatosis to cirrhosis Hepatology 2006 43 S99–112 56 Panagaria N, Varma K, Nijhawan S, Mathur A, Rai RR. Quality of life and nutritional status in alcohol addicts and patients with chronic liver disease. Trop. Gastroenterol 2007; 28: 171–5. Panagaria N Varma K Nijhawan S Mathur A Rai RR Quality of life and nutritional status in alcohol addicts and patients with chronic liver disease Trop. Gastroenterol 2007 28 171 – 5 57

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Do statins induce or protect from acute kidney injury and chronic kidney disease: An update review in 2018

complaints, ranging from mild serum creatine kinase elevations and myalgia to severe muscle weakness, muscle cramps, myositis and rhabdomyolysis.[ 30 ] Amongst others, CKD is a common risk factor for the development of statin-induced myopathy. Patients with CKD may become more prone to this invalidating and potential life-threatening complication when other significant risk factors ( e . g ., advanced age, female gender, liver dysfunction, diabetes mellitus, etc .) are accumulating. One case report described acute rhabdomyolysis and purpura fulminans in a patient who

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Nutritional Deficiencies Associated to Bariatric Surgery

bypass surgery. N Engl J Med 357: 753-761, 2007. 16. Melissas J . IFSO guidelines for safety, quality, and excellence in bariatric surgery. Obes Surg 18: 497-500, 2008. 17. Toh SY, Zarshenas N, Jorgensen J. Prevalence of nutrient deficiencies in bariatric patients. Nutrition 25: 1150-1156, 2009. 18. Chapman AE, Kiroff G, Game P et al . Laparoscopic adjustable gastric banding in the treatment of obesity: a systematic literature review. Surgery 135: 326-351, 2004. 19. Giusti V, Suter M, Héraïef E

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Exploring patient characteristics and barriers to Hepatitis C treatment in patients on opioid substitution treatment attending a community based fibro-scanning clinic

Introduction Hepatitis C virus (HCV) infection remains a major public health burden. It is spread by contact with infected blood or other bodily fluids. [ 1 - 6 ] An estimated 185 million people are infected with HCV globally [ 7 ] with a reported 15 million Europeans living with HCV infection. [ 8 , 9 ] Chronic disease outcomes occur in 55-85% of untreated cases, and center around an impaired quality of life, liver cirrhosis, liver failure and hepatocellular carcinoma. [ 10 , 11 ] Injecting drug use remains a significant driver of the European HCV

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Glycemic Key Metrics and the Risk of Diabetes-Associated Complications

Glucose (ADAG) study. Diabetologia 54: 69-72, 2011. 10. Barr EL, Zimmet PZ, Welborn TA et al. Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Life Style Study (AusDiab). Circulation 116: 151-157, 2007. 11. Monami M, Adalsteinsson JE, Desideri CM, Ragghianti B, Dicembrini I, Mannucci E. Fasting and post-prandial glucose and diabetic complication. A metaanalysis. Nutr Metab Cardiovasc Dis 23: 591-598, 2013

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