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MicroRNA regulated macrophage activation in obesity

-supported by its performance on the samples from human and murine species, under in vitro and in vivo conditions, and in bulk and single-cell sequencing formats. Importantly, MacSpectrum revealed an unprecedented sequential activation pattern of monocytes/macrophages in obesity and unique cell programs under the regulation of miRNAs. The performance of MacSpectrum suggests that novel bioinformatic algorithms tailored to macrophage study could provide promising strategies to address the challenges of investigating miRNA-regulated activation in obesity and facilitate more

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Comparative computed flow dynamic analysis of different optimization techniques in left main either provisional or culotte stenting

. At the wall opposite to the carina, the SKB, 2SK, and POT–KB-POT techniques provide the best performance in terms of rheology with a very small area of low WSS and high WSS value in general, while the KB and POT-side-POT techniques resulted again as the worst performers ( Table 3 , Figure 3 ). Discussion Our study suggested that from a fluid dynamic point of view, for LM provisional stenting, the POT, KB and 2SK techniques showed similar beneficial impacts on the bifurcation rheology, which were of higher WSS at the opposite wall and smaller surface area of

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Therapeutic approaches of obstructive sleep apnea in China

Obstructive sleep apnea (OSA) is characterized by repetitive episodes of complete and partial obstructions of upper airway during sleep. In general population, OSA is highly prevalent and affects approximately 34% of men and 17% of women in aged 30-70 years.[ 1 ] Individuals with OSA experience a variety of symptoms and conditions such as fatigue, excessive daytime sleepiness, impaired cognitive performance, headache, and an increased incidence of motor vehicle accidents. Many studies have shown a link between OSA and cardiovascular disease, chronic heart

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Protracted inhibition of vascular endothelial growth factor signaling improves survival in metastatic colorectal cancer: A systematic review

.4) (61) (39) (29.6) (70.4) (0) (51.3) (48.7) (0) ECOG: ECOG performance status; Line: line of treatment for metastatic disease; WT: wild-type; MT: mutant; n.r.: not reported; M: male; F: female; CHT: chemotherapy. Numbers in parenthesis indicate the percentage on total. Table 2 Summary of risk of bias assessment. TML Bebyp RAISE VELOUR CORRECT CONCUR Sequence Generation Low Low Low Low Low Low Allocation Concealment Low Low Low Low Low Low Blinding of participants

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Viral hepatitis in hemodialysis: An update

K, Ohue C, Matsunaga Y, Tanaka E, Kiyosawa K, et al. Performance of a conventional enzyme immunoassay for hepatitis C virus core antigen in the early phases of hepatitis C infection. Clin Lab 2001;47:119-27. 149. Hosokawa N, Esumi M, Iwasaki Y, Yanai M, Enomoto A, Kawano K. Phylogenetic evidence, by multiple clone analysis of hypervariable region 1, for the transmission of hepatitis C virus to chronic haemodialysis patients. J Viral Hepat 2000;7:276-82. 150. Izopet J, Pasquier C, Sandres K, Puel J, Rostaing L. Molecular evidence for

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Citrate: How to get started and what, when, and how to monitor?

will be enough in 99% of the cases and surely when using the predilution system as lower concentrations are used). Metabolic acidosis due to failure to metabolize citric acid can be diagnosed early by routine metabolic monitoring. It is corrected by discontinuing or tapering the dose of citrate and by adjusting the replacement fluid. In case of metabolic alkalosis, large amounts of citrate may enter the systemic circulation. If ultrafiltration flow gradually declines as a result of decreased filter performance induced by increased clogging, while blood flow is

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Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected

effects of n-3 fatty acids from linseed oil and fish oil in well-controlled type 2 diabetes. Diabetes Care 19, 463–467, 1996. Mehta A, Oeser AM, Carlson MG. Rapid quantitation of free fatty acids in human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 719, 9–23, 1998. Montori V, Wollan P, Farmer A, Dinneen S. Fish oil supplementation in type 2 diabetes. Diabetes Care 23, 1407–1415, 2000. Moore PC, Ugas MA, Hagman DK, Parazzoli SD, Poitout V. Evidence against the involvement of oxidative stress in fatty acid inhibition

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Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain

ischemia. Glia 50, 329–339, 2005. Diano S, Farr SS, Benoit SC, McNay EC, Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks MA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, Sleeman MW, Tschop MH, Horvath TL. Ghrelin controls hippo-campal spine synapse density and memory performance. Nat Neurosci 9, 381–388, 2006. Duansak N, Schmid-Schonbein GW. The oxygen free radicals control MMP-9 and transcription factors expression in the spontaneously hypertensive rat. Microvasc Res 90, 154–161, 2013. Duran-Vilaregut J, del Valle J, Manich G, Camins A

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Bidirectional asymmetry in the neurovisceral communication for the cardiovascular control: New insights

kidney angiotensinase activities in spontaneously hypertensive rats. Planta Med 81, 664–669, 2015. Williams DP, Cash C, Rankin C, Bernardi A, Koenig J, Thayer JF. Resting heart rate variability predicts self-reported difficulties in emotion regulation: a focus on different facets of emotion regulation. Front Psychol 6, 261, 2015. Xavier CH, Beig MI, Ianzer D, Fontes MA, Nalivaiko E. Asymmetry in the control of cardiac performance by dorsomedial hypothalamus. Am J Physiol Regul Integr Comp Physiol 304, R664–R674, 2013. Xu B, Zheng H, Patel KP. Enhanced

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A short review of primary aldosteronism in a question and answer fashion

. Characterization of adrenal masses by using FDG PET: a systematic review and meta-analysis of diagnostic test performance. Radiology 259, 117-126, 2011. Brown NJ. Aldosterone and end-organ damage. Curr Opin Nephrol Hypertens 14, 235-241, 2005. Brown MJ. Primary Aldosteronism: the spectre of cure. Clin Endocrinol (Oxf) 82, 785-788, 2015. Brunt LM. Minimal access adrenal surgery. Surg Endosc 20, 351-361, 2006. Brunt LM, Moley JF. Adrenal incidentaloma. World J Surg 25, 905-913, 2001. Burton TJ

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