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Increase in albumin by daclatasvir/asunaprevir therapy is correlated with decrease in aspartate transaminase

) and asunaprevir (ASV; NS3/4A protease inhibitor) for patients with HCV genotype 1b. DCV/ASV therapy increased the sustained virological response (SVR) rate to about 90% and caused less adverse effects than IFN-based therapy.[ 3 – 7 ] In Japan, DCV/ASV therapy can be administered to patients with chronic hepatitis or compensated cirrhosis with a Child-Pugh score of 6 or less, but not to those with decompensated cirrhosis with a Child-Pugh score of 7 or more. In some other countries, IFN-free therapy is authorized for patients with decompensated cirrhosis, and high

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Timing of anticoagulation for portal vein thrombosis in liver cirrhosis: An Italian internist’s perspective

on warfarin 2.5 mg daily and afterwards titrated to achieve INR target range 2.0–3.0. Approximately 83% of the study population started anticoagulant treatment within 3 months since PVT diagnosis. Untreated patients during the same period (between 2002–2014) constituted the control group. Recanalization was significantly more frequent in treated patients (68.2% vs . 25%).[ 23 ] Finally, a propensity score matching the analysis of 14 cirrhotic patients with PVT who received warfarin and 14 patients who were not anticoagulated confirmed higher rates of

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China may hold answers to addressing cardiovascular disease epidemic

, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014 U.S. Department of Health and Human Services The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General Atlanta U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health 2014 7 Hajifathalian K, Ueda P, Lu Y, Woodward M, Ahmadvand A, AguilarSalinas CA, et al . A novel risk score to predict cardiovascular

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Dyspepsia amongst end stage renal disease undergoing hemodialysis: Views from a large tertiary care center

hemodialysis were consecutively enrolled in the study. The study was conducted at the Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan, a large tertiary care center that caters to a significant number of dialysis patients from all over Pakistan. Dyspepsia was labelled after using the LDQ questionnaire, in those with a score equal or greater than 5 over the period of last four weeks.[ 7 ] Since the LDQ is long and cumbersome, and was not designed for self-completion, we modified the questionnaire for use in our setting. The LDQ questionnaire originally

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A little help from steroids in oncology

uncontrolled study among 106 consecutive patients with advanced cancer dexamethasone treatment was started according to the established prescription policy. [ 3 ] The most common specific indications for treatment with dexamethasone were spinal cord compression, cerebral metastases, lymphangitic carcinomatosis, and bowel obstruction. The most common nonspecific indications comprised anorexia, nausea, low mood, pain, and vomiting. The median duration of steroid use was 21.5 days (range: 1–89 days). Symptom scores improved during the therapy compared with the baseline in most

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Ongoing transmission of HCV: Should cesarean section be justified? Data mining discovery

Elakel W Ghoneim H et al. Coinfection with hepatitis C virus and schistosomiasis: Fibrosis and treatment response World J Gastroentrol 2013 19 2691 6 21 Alboraie M, Khairy M, Elsharkawy M, Asem N, Elsharkawy A, Esmat G. Value of Egy-Score in diagnosis of significant, advanced hepatic fibrosis and cirrhosis compared to aspartate aminotransferase-to-platelet ratio index, FIB-4 and Forns’ index in chronic hepatitis C virus. Hepatol Res 2015; 45: 560-70. 10.1111/hepr.12385 Alboraie M Khairy M Elsharkawy M Asem N Elsharkawy A Esmat G. Value of

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Timing of the treatment of portal vein thrombosis in patients with cirrhosis: A German hepatologist’s perspective

contribute to the development of portal vein thrombosis in patients with cirrhosis Thromb Res 2013 131 173 77 5 Zocco MA, Di Stasio E, De Cristofaro R, Novi M, Ainora ME, Ponziani F, et al . Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis development. J. Hepatol 2009;51: 682-9. 10.1016/j.jhep.2009.03.013 Zocco MA Di Stasio E De Cristofaro R Novi M Ainora ME Ponziani F Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis

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Therapeutic approaches of obstructive sleep apnea in China

established one among Caucasians named Hoffstein formula. The predictive equation was shown as follows: predicted pressure (cm H 2 O) = 6.656 + 0.156 × (body mass index [kg/m 2 ]) – 0.071 × (minimal SpO 2 [%]) + 0.041 × (respiratory disturbance index) + 0.094 × (score of Epworth Sleepiness).[ 8 ] Noteworthy, this formula provided an optimal estimation of CPAP pressure for a low proportion of subjects (38%), thus the predictive equation is not a sufficient substitute for the manual CPAP titration. But the use of the CPAP prediction formula may improve manual CPAP titration

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Clinical conundrums in the management of diabetic ketoacidosis in the elderly

transplantation by risk prediction models. Diabetes Care 2012; 35: 471-3. 10.2337/dc11-2071 Rodrigo E Santos L Piñera C Eagan J Reddy P Lesko SM Prediction at first year of incident new-onset diabetes after kidney transplantation by risk prediction models Diabetes Care 2012 35 471 3 6 Yu CH, Straus S, PhD RB. The ABCs of DKA: Development and Validation of a Computer-Based Simulator and Scoring System. J Gen Intern Med 2015; 30: 1319-32. 10.1007/s11606-015-3273-y Yu CH Straus S PhD RB The ABCs of DKA: Development and Validation

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Advances in Stroke Prevention

significantly better than anticoagulants. As ~25% of the population has a PFO, and only ~5.5% of strokes are due to paradoxical embolism, the PFO will be incidental in ~80% of all stroke patients and ~50% of those with ESUS. [ 45 ] The ROPE score [ 46 ] mentioned in the Editorial assesses the likelihood that a stroke is an embolic stroke of unknown source (ESUS). There can be serious complications of percutaneous closure. These include embolization of the device, with fatal obstruction of the aortic valve, or embolization to distal arteries requiring emergency surgery

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