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Yifei Zhang, Xiaojing Song, Xixun Wang, Jinchen Hu and Lixin Jiang

transcribed sequences with genome tiling arrays. Science 2004; 24; 306(5705): 2242–6. 5. Kapranov P, Drenkow J, Cheng J, Long J, Helt G, Dike S, et al. Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays. Genome research 2005; 15(7): 987–97. 6. Ji P, Diederichs S, Wang W, Boing S, Metzger R, Schneider PM, et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 2003; 22(39): 8031–41. 7. Srikantan V, Zou Z

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Nikolina Babić

commercial platforms for warfarin sensitivity genotyping. Clin Chim Acta 2009; 406: 143-7. 21. Wade, N. Cost of decoding a genome is lowered. New York Times 2009. 22. Staff B-IW. Illumina announces $5,000 genome pricing. Bio IT News 2011. 23. Grossman I. Routine pharmacogenetic testing in clinical practice: dream or reality? Pharmacogenomics 2007; 8: 1449-59. 24. Valdes R, Payne D, Linder M. Guidelines and recommendations for laboratory analysis and application of phar - macogenetics to clinical practice

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Mohammad Najafi, Morteza Nouruzi Yeganeh, Arezoo Miraftabi, Reza Zarei and Isa Noormohammadi

, Bunce C, Viswanathan AC. Gene Finding in Primary Open-angle Glaucoma. J Glaucoma 2012; doi: 10.1097/IJG.0b013e318255bc37. 10. Colak D, Morales J, Bosley TM, Al-Bakheet A, Alyounes B, Kaya N, Abu-Amero KK. Genome-wide expression profiling of patients with primary open angle glaucoma. Invest Ophthalmol Vis Sci 2012; 53(9): 5899-904. 11. Brown KM, Arthur JR. Selenium, selenoproteins and human health: a review. Public Health Nutr 2001; 4(2B): 593-9. 12. Zhu X, Guo K, Lu Y. Selenium effectively inhibits 1

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Małgorzata Popis, Blanka Borowiec and Maurycy Jankowski

. 7. Nüsslein-Volhard C. Genetic analysis of pattern-formation in the embryo of Drosophila melanogaster - Characterization of the maternal-effect mutant Bicaudal. Wilhelm Roux's Arch Dev Biol. 1977;183:249–68; DOI:10.1007/BF00867325. 8. Sega GA. A review of the genetic effects of ethyl methanesulfonate. Mutat Res Genet Toxicol. 1984;134:113–42; DOI:10.1016/0165-1110(84)90007-1. 9. Hoy MA. Genetic Systems, Genome Evolution, and Genetic Control of Embryonic Development in Insects. Insect Mol. Genet., Academic Press. 2013;103–79; DOI:10.1016/B978

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Vladimir V. Đorđević, Tatjana Jevtović-Stoimenov, Dušan Lazarević, Ivana Stojanović, Ljiljana Trajanović, Olivera Žikić and Vidosava Đorđević

–63. 28. Zheng Y, Li H, Quin W, Duan Y, Li C, Zhang J, et al. Association of the carboxyl-terminal PDZ ligand of the neuronal nitric oxide synthase gene with schizophrenia in the Chinese Han population. Biochem Biophys Res Commun 2005; 328: 809–15. 29. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, et al. Molecular genetics of schizophrenia collaboration. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 2008; 40: 3–5. 30. Schanze D, Ekici AB, Gawlik M, Pfuhlmann B, Reis A, Stöber G

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Fatemeh Amin, Mohammad Mehdi Jahani, Hamid Ghaedi, Behnam Alipoor, Ahmad Fatemi, Michael Tajik, Zohreh Sharifi, Taghi Golmohammadi, Mohammad Askari, Asaad Azarnejad, Sadegh Alipoor, Aliasghar Valipour and Kazem Mousavizadeh

, Meyer LR, Pohl A, et al. ENCODE whole-genome data in the UCSC Genome Browser. Nucleic Acids Research 2010; 38(suppl 1): D620-D5. 28. Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O’Donnell CJ, de Bakker PI. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 2008; 24(24): 2938–9.

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Dragana Janic, Jelena Peric, Teodora Karan-Djurasevic, Tatjana Kostic, Irena Marjanovic, Bojana Stanic, Nadja Pejanovic, Lidija Dokmanovic, Jelena Lazic, Nada Krstovski, Marijana Virijevic, Dragica Tomin, Ana Vidovic, Nada Suvajdzic Vukovic, Sonja Pavlovic and Natasa Tosic

ends using FastqMcf ( 9 ). Then the production of BAM file(s) was done with BWA-MEM ( 10 , 11 , 12 ). This step involved the alignment of sequences with the reference genome GRCh37. The insertions/deletions (indel) realignment over the reads overlapping target regions was performed using RealignerTargetCreator and IndelRealigner ( 13 , 14 ). SBG developed custom scripts that was used for additional quality control which consisted of counting reads of each amplicon and identifying amplicons presenting low read-coverage across all samples. The variant calling and

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Tamer Bego, Adlija Čaušević, Tanja Dujić, Maja Malenica, Zelija Velija-Asimi, Besim Prnjavorac, Janja Marc, Jana Nekvindová, Vladimír Palička and Sabina Semiz

). It is well known that the risk of developing T2D is associated with obesity which is now a major global problem, considering that approximately 1.1 billion people worldwide are overweight, while 312 million are obese ( 3 , 4 ). GWA (genome-wide associated) studies identified around 15 candidate genes responsible for an increase in the visceral depots (which is associated with a number of metabolic disorders such as metabolic syndrome, T2D, and cardiovascular disease) ( 1 ). Therefore, it is important to know which genetic loci are associated with obesity in order

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Danijela Vojnović Milutinović, Djuro Macut, Ivana Božić Antić, Jelica Bjekić Macut, Marina Nikolić, Gordana Matić and Jelena Nestorov

; 17(2): 263–74. 18. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3(7): RESEARCH0034. PMCID: 126239. 19. Andersen CL, Jensen JL, Orntoft T F. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 2004; 64(15): 5245–50. 20. Bustin SA

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Nada Majkić-Singh

clinical integration necessitate a review of biomarker terminology and validation schema. Scand J Clin Lab Invest 2010; 70 (Suppl 242): 3: 6-14. Food and Drug Administration, Department of Health and Human Service. Approval based on a surrogate endpoint or on an effect on a clinical endpoint other than survival or irreversible morbidity, 2009: 5: 21CFR314.510. Loukopoulos P, Shibata T, Katoh H, Kokubu A, at al. Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma