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Urszula Lisiecka and Krzysztof Kostro

. Beatty G.L., Gladney W.L.: Immune escape mechanisms as a guide for cancer immunotherapy. Clin Cancer Res 2015, 21, doi: 10.1158/1078-0432. 4. Beyer M., Schultze J.L.: Regulatory T cells: major players in the tumor microenvironment. Curr Pharm Des 2009, 15, 1879-1892. 5. Biller B.J., Elmslie R.E., Burnett R.C., Avery A.C., Dow S.W.: Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer. Vet Immunol Immunopathol 2007, 116, 69-78. 6. Biswas S.K., Lewis C.E.: NF-κB as a central regulator

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Mousa Mohammadnia-Afrouzi and Soheil Ebrahimpour

REFERENCES 1. Skendros P. et al.: Cell-mediated immunity in human brucellosis. Microbes Infect. 2011;13:134. 2. Gomez G. et al.: Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis. Front Cell Infect Microbiol.,3,1,2013. 3. Mangodt TC. et al.: The role of Th17 and Treg responses in the pathogenesis of RSV infection. Pediatr Res.,78,483,2015. 4. Mohammadnia-Afrouzi M. et al.: Altered microRNA Expression and Immunosuppressive Cytokine Production by Regulatory T Cells

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Ming Guo

the transcription of CXCR5 after combining with these regulatory elements [ 7 ]. E2A activates the transcription of CXCR5, whereas Blimp1 causes its inhibition. In addition to directly regulating the expression of CXCR5, transcription factors Blimp1 and E2A may also form transcription pathways with inhibitor of differentiation 2 (Id2) and Id3 profiling of B cell lymphoma-6 (Bcl6), T-cell factor 1 (TCF-1), and E2A, thereby controlling expression of CXCR5 and formation of TFCs. Expressions of inhibitory molecules such as T cell immunoglobulin domain and mucin domain

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E. Krasimirova and D. Kyurkchiev

. Transcriptional regulation of Th1/Th2 polarization. – Immunol Today, 21, 2000, № 10, 479-483. 20. Chung Y., S. H. Chang, G. J. Martinez et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. – Immunity, 30, 2009, № 4, 576-587. 21. Chen W. J., W. Jin, N. Hardegen et al. Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3. – J Exp Med, 198, 2003, № 12, 1875-1886. 22. Zheng S. G., J. Wang, P. Wang et al. IL-2 Is Essential for TGF-β to Convert Naive CD4

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M. Szczotka, J. Kuźmak, K. Kostro, D. Bednarek and M. Purzycka

( 2000 ) Induction of Interleukin 10 - producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192: 1213-1222. Kukutsch NA, Rossner S, Austyn JM, Schuler G, Austyn J ( 2000 ) Formation and kinetics of MHC class I-ovalbumin peptide complexes on immature and mature murine dendritic cells. J Invest Dermatol 115: 449-453. Moll H, Fuchs H, Blank C, Rollinghoff M ( 1993 ) Langerhans cells transport Leishmania major from the infected skin to the

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Miha Skvarc, David Stubljar, Andreja Natasa Kopitar, Samo Jeverica, Bojan Tepes, Janko Kos and Alojz Ihan

: 559-70. 17. Wang X, Uto T, Sato K, Ide K, Akagi T, Okamoto M, et al. Potent activation of antigen-specific T cells by antigen-loaded nanospheres. Immunol Lett 2005; 98: 123-30. 18. Robinson K, Kenefeck R, Pidgeon EL, Shakib S, Patel S, Polson RJ, et al. Helicobacter pylori -induced peptic ulcer disease is associated with inadequate regulatory T cell responses . Gut 2008; 57: 1375-85. 19. Zhang M, Liu M, Luther J, Kao JY. Helicobacter pylori directs tolerogenic programming of dendritic cells. Gut Microbes

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Jerzy Kawiak, Grazyna Hoser and Joanna Domagała-Kulawik

, Scagliotti GV. First-line therapeutic options for advanced non-small-cell lung cancer in the molecular medicine era. Future Oncol 2014; 10(6): 1081-1093. [12] Caramalho I, Nunes-Cabaco H, Foxall RB, Sousa AE. Regulatory T-Cell Development in the Human Thymus. Front Immunol 2015; 6: 395. [13] Martins VC, Busch K, Juraeva D, Blum C, Ludwig C, Rasche V, Lasitschka F, Mastitsky SE, Brors B, Hielscher T, Fehling HJ, Rodewald HR. Cell competition is a tumour suppressor mechanism in the thymus. Nature. 2014 May22; 509(7501): 465

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Anca Chiriac, Piotr Brzezinski, Meda Bradeanu, Adrian Năznean, Cristian Podoleanu and Simona Stolnicu

occupancy, CD56bright NK cell expansion, and regulatory T cell reduction by daclizumab HYP in subjects with multiple sclerosis. Br J Clin Pharmacol . 2016;82:1333-1342. 7. Michel T, Poli A, Cuapio A et al. Human CD56bright NK Cells: An Update. J Immunol . 2016; 196:2923-2931.

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Supreecha Chattong, Ruttachuk Rungsiwiwut, Wittaya Yindeedej, Amornpun Sereemaspun, Kamthorn Pruksananonda, Pramuan Virutamasen, Anant Setpakdee and Krissanapong Manotham

SC, Stewart MH, Menendez P, George D, Vijayaragavan K, Werbowetski-Ogilvie T, et al. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature. 2007; 448:1015-21. 22. Lei T, Jacob S, Ajil-Zaraa I, Dubuisson JB, Irion O, Jaconi M, Feki A. Xeno-free derivation and culture of human embryonic stem cells: current status, problems and challenges. Cell Res. 2007; 17:682-8. 23. Swistowski A, Peng J, Han Y, Swistowska AM, Rao MS, Zeng X. Xeno-free defined conditions for culture of human

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Thanh Luan Nguyen, Jae Gyu Yoo, Neelesh Sharma, Sung Woo Kim, Yong Jun Kang, Hai Ha Pham Thi and Dong Kee Jeong

References Aponte P.M., Soda T., Teerds K.J., Mizrak S.C., Vande Kant H.J., Derooij D.G. (2008). Propagation of bovine spermatogonial stem cells in vitro. Reproduction, 136: 543-557. Brulet P., Babinet C., Kemler R., Jacob F. (1980). Monoclonal antibodies against trophectoderm- specific markers during mouse blastocyst formation. Proc. Natl. Acad Sci. USA, 77: 4113-4117. Burt D.W. (2007). Emergence of the chicken as model organism: Implications for agriculture and biology. Poultry Sci., 86: 1460