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Tyreoliberin (Trh) – The Regulatory Neuropeptide of Cns Homeostasis


The physiological role of thyreoliberin (TRH) is the preservation of homeostasis within four systems (i) the hypothalamic-hypophsysiotropic neuroendocrine system, (ii) the brain stem/midbrain/spinal cord system, (iii) the limbic/cortical system, and (iv) the chronobiological system. Thus TRH, via various cellular mechanisms, regulates a wide range of biological processes (arousal, sleep, learning, locomotive activity, mood) and possesses the potential for unique and widespread applications for treatment of human illnesses. Since the therapeutic potential of TRH is limited by its pharmacological profile (enzymatic instability, short half-life, undesirable effects), several synthetic analogues of TRH were constructed and studied in mono- or adjunct therapy of central nervous system (CNS) disturbances. The present article summarizes the current state of understanding of the physiological role of TRH and describes its putative role in clinical indications in CNS maladies with a focus on the action of TRH analogues.

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In Vivo Testing of Xenogeneic Acellular Aortic Valves Seeded with Stem Cells

Valve Scaffolds Obtained by Complete Decellularization of Porcine Aortic Roots in a Novel Differential Pressure Gradient Perfusion System. Tissue Eng Part C Methods. 2015 Dec;21(12):1284-96. DOI: 10.1089/ten.tec.2015.0170. 6. Gimble J, Guilak F. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy. 2003;5(5):362-9. DOI: 10.1080/14653240310003026. 7. Schoen FJ. Heart valve tissue engineering: quo vadis? Curr Opin Biotechnol. 2011 Oct;22(5):698-705. DOI: 10.1016/j.copbio.2011

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“Cell cycle process”, “cell division” and “cell proliferation” belong to ontology groups highly regulated during long–term culture of porcine oviductal epithelial cells

Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a. Stem Cells. 2017;35(8):1948–57; DOI: 10.1002/stem.2648. 19. Migueles RP, Shaw L, Rodrigues NP, May G, Henseleit K, Anderson KGV, et al. Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny. Dev Biol. 2017;424(2):236–45; DOI: 10.1016/j.ydbio.2016.12.021. 20. Holets LM, Hunt JS, Petroff MG. Trophoblast CD274 (B7-H1) Is Differentially Expressed Across Gestation: Influence of Oxygen Concentration1. Biol Reprod. 2006;74(2):352–8; DOI: 10

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Amino acids metabolism and degradation is regulated during porcine oviductal epithelial cells (OECs) primary culture in vitro – a signaling pathways activation approach

References 1. Kranc, W. et al. , “The origin, in vitro differentiation, and stemness specificity of progenitor cells.,” J. Biol. Regul. Homeost. Agents , vol. 31, no. 2, pp. 365-369, 2017. 2. Groth, C. G., “The potential advantages of transplanting organs from pig to man: A transplant Surgeon’s view.,” Indian J. Urol. , vol. 23, no. 3, pp. 305-9, Jul. 2007. 3. Denner, J., “Xenotransplantation-Progress and Problems: A Review,” J. Transplant. Technol. Res. , vol. 4, no. 2, Jul. 2014. 4. Kranc, W. et al. , “Molecular basis of growth

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Hmga2 Expression in Renal Carcinoma and its Clinical Significance / Ekspresija Hmga2 U Karcinomu Bubrega I Njen Klinički Značaj

-11. 13. Miyazawa J, Mitoro A, Kawashiri S, Chada KK, Imai K. Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity. Cancer Res 2004; 64: 2024-9. 14. Fehr A, Meyer A, Heldorn K, Röser K, Löning T, Buller - diek J. A link between the expression of the stem cell marker HMGh2, grading, and the fusion CRTCl-MAML2 in mucoepidermoid carcinoma. Genes Chrom Cancer 2009; 48: 777-85. 15. De Martino I, Visone R, Wierinckx A, Palmieri D, Ferraro A, Cappabianca P, et al. HMGA proteins up-regulate CCNB2 gene in

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Tumor Blood Vessels and Vasculogenic Mimicry – Current Knowledge and Searching for New Cellular/Molecular Targets of Anti-Angiogenic Therapy

References [1] Ailles LE, Weissman IL. Cancer stem cells in solid tumors. Curr Opinion Biotech 2007; 18: 460-466. [2] Alameddine RS, Hamich L, Shamseddine A. From sprouting angiogenesis to erythrocytes generation by cancer stem cells: evolving concepts in tumor microcirculation. BioMed Res Int 2014; 2014: doi 10.1155/2014/986768. [3] Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and

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Epithelium morphogenesis and oviduct development are regulated by significant increase of expression of genes after long-term in vitro primary culture – a microarray assays

Domest Anim. 2008;43(1):66-73; DOI:10.1111/j.1439-0531.2007.00856.x. 11. White KL, Hehnke K, Rickords LF, Southern LL, Thompson DL Jr, Wood TC. Early embryonic development in vitro by coculture with oviductal epithelial cells in pigs. Biol Reprod. 1989;41(3):425-30. 12. Kessler M, Hoffmann K, Brinkmann V, Thieck O, Jackisch S, Toelle B, Berger H, Mollenkopf HJ, Mangler M, Sehouli J, Fotopoulou C, Meyer TF. The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Nat Commun. 2015;6:8989; DOI:10.1038/ncomms9989

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Recommendations for use of Tumor Markers in Monoclonal Gammopathies

for multiple myeloma. J Clin Oncol 2005; 23 : 3412-20. Singhal S, Mehta J. Multiple myeloma. Clin J Am Soc Nephrol 2006; 1 : 1322-30. Bjorkstrand BB, Ljungman P, Svensson H, Hermans J, Alegre A, Apperley J, et al. Allogeneic bone marrow transplantation versus autologous stem cell transplatation in multiple myeloma: a retrospective case-matched study from the European Group for Blood and Marrow Transplantation. Blood 1996; 88 : 4711-8. Child JA, Morgan GJ, Davies FE, Owen RG, Bell

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Tadeusz Stefan Kurkiewicz (1885-1962) – His Important Contribution to Contemporary Cardiology

CE. The origin of the epicardium and the embryonic myocardial circulation in the mouse. Anatomical Rec. 1981;201:157-168. DOI: 10.1002/ar.1092010117 15. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003;114:763–776. 16. Shiozaki M. Shimada Y. Intercellular junctions in embryonic chick cardiac muscle revealed by rapid freezing and freeze-substitution. Microscopy Res Tech. 1992

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Evaluation of Platelet Activation Parameters as Quality Markers for the Stored Platelets

-7. Vaickus L, Breitmeyer JB, Schlossman R, Anderson KE. Platelet transfusion and alternatives to transfusion in patients with malignancy. Stem Cells 1995; 13: 588-96. Fijnheer R, Pietersz RN, De Korte D, Gouwerok CW, Dekker WJ, Reesink HW, et al. Platelet activation during preparation of platelet concentrates: a comparison of the platelet-rich plasma and the buffy-coat methods. Transfusion 1990; 30: 634-8. Pietersz RNI, Loos JA, Reesink HW. Platelet concentrates stored in plasma for 72 hours at 22 C prepared from

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