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Prognostic Value Of Normal Myocardial Perfusion Imaging In Asymptomatic Diabetic Patients With Moderate And High Calcium Scores

Abstract

The purpose of this study was to evaluate the intermediate prognostic value of normal myocardial perfusion imaging (MPI) in asymptomatic diabetic patients with intermediate and high coronary artery calcium (CAC) scores. Methods: A total of 115 asymptomatic diabetic patients with no known coronary artery disease (CAD) underwent MPI after multi-slice computed tomography CAC assessment for the detection of suspected CAD. The study included 75 patients with normal MPI results. A 17-segment model for myocardial perfusion and function analysis was used. Patients were divided into three groups: I gr-20 patients with a diabetes duration between 1-5 years; II gr-24 patients with a diabetes duration 5-10 years; and III gr-31 patients with a diabetes duration >10 years. End points (cardiac death, non-fatal myocardial infarction, heart failure, new angina, revascularization) were assessed at 6, 12 and 24 months.

All patients had normal resting left ventricular function and normal myocardial perfusion scans. Forty patients had moderate coronary artery calcification with an average CAC of 290+/−95. Thirty-five patients had severe coronary calcification with an average CAC of 568+/−67. A correlation was found between diabetes duration and CAC severity (r-0,62 for diabetes duration over 10 years). Three cardiac events were identified at 24--month follow-up (new angina with percutaneous coronary intervention-PCI). Hard events (cardiac death, nonfatal myocardial infarction) were observed at a rate of 0% in group I, 4.2% in group II and 6.4% in group III. The overall event rate at 24--month follow-up was 4.0%.

MPI and CAC are valuable techniques for the preclinical assessment of CAD in asymptomatic diabetic patients. This could guide decision-making to result in optimal treatment and prognosis. Even diabetic patients with normal MPI are at increased intermediate risk for CV events.

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Endoscopic and histological staging: Deciding factors in the treatment of chronic rhinosinusitis

D., Wormald P.J. - Chronic rhinosinusitis assessment using the Adelaide Disease Severity Score. J Laryngol Otol., 2013;127(Suppl 2):S24-8. 3. Rizk H.G., Ferguson B.J. - Categorizing Nasal Polyps by Severity and Controller Therapy. Arch Otolaryngol Head Neck Surg., 2012;138(9):846-53. 4. Lund V.J., Mackay I.S. - Staging in rhinosinusitis. Rhinology, 1993;107:183-4. 5. Moghadasi H., et al. - Association bBetween Clinical Symptoms and CT Findings in Chronic Rhinosinusitis. Iran J Radiol., 2008

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Effect of pentoxifylline on histological activity and fibrosis of nonalcoholic steatohepatitis patients: A one year randomized control trial

NASH. Only few studies and pilot trials of PTX[ 14 - 16 ] suggested that pentoxifylline reduced plasma TNF- α and IL-6, ALT and AST levels but there is scarcity of data to observe improvement of NAFLD activity score (NAS) and fibrosis score in patients with nonalcoholic steatohepatitis (NASH). The aim of this study was to observe the effect of pentoxifylline on histological activity and fibrosis of Bangladeshi nonalcoholic steatohepatitis patients. Materials and methods This study was conducted from August 2014 to December 2015 as an open label Randomized

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Correlation of Residual Diuresis with MIS Score and Nutritional Status in Peritoneal Dialysis Patients: A Croatian Nationwide Study

Abstract

Introduction. Residual diuresis (RD) is an important predictor of mortality and cardiovascular (CV) deaths in peritoneal dialysis (PD) patients, and contributes more to overall survival compared to PD clearance. In this study we investigated the correlation between RD and CV outcomes in PD patients.

Methods. A total of 190 PD patients from 13 dialysis centers, a national representation, were included in this analysis. Biomarkers of anemia, nutritional status [malnutrition inflammation score (MIS), subjective global assessment (SGA), serum albumin, anthropometric measurements including body mass index (BMI)], dialysis dose (Kt/V) and laboratory measurements were determined. RD was estimated using the volume of daily urine.

Results. There were 78(41.05 %) females and 112 (58.95 %) males; aged 57.35±14.41 years, on PD for 24.96±24.43 months. Fifty-six patients had diabetes type II (44 as primary kidney disease). The mean RD was 1170±673.6 ml (range 0-3000 mL). Statistically significant correlations between RD and BMI, hip circumference, time on PD, Kt/V, MIS, SGA, erythrocytes (E), Hemoglobin (Hb), PTH, and serum albumin were observed.

Conclusions. We demonstrated a significant correlation between RD and MIS score, SGA, anthropometry and albumin. Every effort should be invested to maintain RD for as long as possible to achieve optimal treatment results and to decrease CV mortality in PD population.

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Contemporary Distribution of High-Grade Prostate Cancer in the Circumstances of Opportunistic Testing

(9):1228-42. PubMed PMID: 16096414. 8. Brawley OW (2012). Trends in prostate cancer in the United States. J Natl Cancer Inst Monogr. 2012(45):152-6. doi: 10.1093/jncimonographs/lgs035. 9. Pepe P, Pennisi M (2015). Gleason score stratification according to age at diagnosis in 1028 men. Contemp Oncol (Pozn). 19(6):471-3. doi: 10.5114/ wo.2015.56654. 10. Muralidhar V, Ziehr DR, Mahal BA, Chen YW, Nezolosky MD, Viswanathan VB, et al. (2015). Association Between Older Age and Increasing Gleason Score. Clin Genitourin Cancer. 13

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Validation of the Slovenian version of the low anterior resection syndrome score for rectal cancer patients after surgery

suffer major defecation dysfunction due to nerve and sphincter damage combined with poor neorectal capacity ( 4 ). The term Low Anterior Resection Syndrome (LARS) was introduced to describe this complex range of symptoms and the LARS score (LARSS) was defined to assess the severity of complaints and its negative impact on the quality of life (QoL) of patients ( 4 ). These patients typically fall into one of two categories: those with faecal incontinence, frequency, and urgency, and those with constipation and feelings of incomplete emptying. Some report features of

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The Relationship Between Pistol Olympic Shooting Performance, Handgrip and Shoulder Abduction Strength

Introduction There are many factors that affect performance in Olympic shooting. Elite shooters are capable of reaching extreme levels of precision and accuracy. In female air pistol shooting, the best shooters often reach scores as high as the current world record (393/400), or in other words success of 98.2% hitting the ten points score. Considering that the maximum score of a shot (10 points) represents accuracy within a circle of a diameter of 11.5 mm ± 0.1 mm from a shooting distance of 10 meters, failure or important loss in performance due to

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Correlations Between Severity of Coronary Calcification and Impairment of Left Ventricular Ejection Fraction

Radiology and Intervention, and the Councils on Clinical Cardiology and Cardiovascular Disease in the Young. Circulation. 2008;118:586-606. 3. Greenland P, Bonow RO, Brundage BH, et al. ACCF/AHA 2007 Clinical Expert Consensus Document on Coronary Artery Calcium Scoring By Computed Tomography in Global Cardiovascular Risk Assessment and in Evaluation of Patients With Chest Pain. Journal of the American College of Cardiology. 2007;49(3):378-402. 4. Benedek T, Gyongyosi M, Benedek I. Multislice Computed Tomographic Coronary Angiography for

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Oxid Comparative Analysis of the Significance of BISAP and MEWS Score for an Early Assessment of Illness Severity and Treatment Outcome of Acute Pancreatitis

late in acute pancreatitis? Int J Pancreatol 2000;28:91–95. DOI:10.1385/IJGC:28:2:091 14. Goldhill DR, McNarry AF. Physiological abnormalities in early warning scores are related to mortality in adult inpatients. British Journal of Anaesthesia 2004; 92: 882-4. DOI:10.1093/bja/aeh113 15. Singh, V., Wu, B. U., Bollen, T. L., Repas, K., Maurer, R., Mortele, K. J., & Banks, P. A. Early Systemic Inflammatory Response Syndrome Is Associated With Severe Acute 16. Pancreatitis. Clinical Gastroenterology and Hepatology2009; 7 (11)1247-1251 17. doi

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Ultrastructural Changes in the Cyclic Corpus Luteum of Dairy Cows with Different Body Condition

-112. 10. Stankiewicz T, Blaszczyk B: Concentrations of bone morphogenetic protein-15 (BMP-15) and growth differentiation factor-9 (GDF-9) in follicular cysts, mono- and polyoocyte follicles in gilts. Acta Vet Beograd 2014, 64: 24-32 11. Edmonson AJ, Lean IJ, Weaver LD, Farver T, Webster G: A body condition scoring chart for Holstein dairy cows. J Dairy Sci 1989, 72: 68-78. 12. Boshier DP, Holloway H, Kitchin LF: A comparison of standard lipid staining techniques used in electron microscopic studies of mammalian tissues. Stain Technol 1984

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