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Is there a role for contrast-enhanced ultrasound in the detection and biopsy of MRI only visible breast lesions?

. Pharmacokinetic analysis of malignant pleural mesothelioma-initial results of tumor microcirculation and its correlation to microvessel density (CD-34). Acad Radiol 2008; 15 : 563-70. 10.1016/j.acra.2007.12.014 Giesel FL Choyke PL Mehndiratta A Zechmann CM von Tengg-Kobligk H Kayser K. Pharmacokinetic analysis of malignant pleural mesothelioma-initial results of tumor microcirculation and its correlation to microvessel density (CD-34) Acad Radiol 2008 15 563 70 10.1016/j.acra.2007.12.014 14 Knopp MV, Weiss E, Sinn HP, Mattern J, Junkermann H, Radeleff J, et al

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Computed tomographic perfusion imaging for the prediction of response and survival to transarterial chemoembolization of hepatocellular carcinoma

. Cardiovasc Intervent Radiol 2012; 35 : 1119-28. 10.1007/s00270-012-0394-0 Malagari K Pomoni M Moschouris H Bouma E Koskinas J Stefaniotou A Chemoembolization with doxorubicin-eluting beads for unresectable hepatocellular carcinoma: five-year survival analysis Cardiovasc Intervent Radiol 2012 35 1119 28 5 Varela M, Real MI, Burrel M, Forner A, Sala M, Brunet M, et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics . J Hepatol 2007; 46 : 474-81. 10.1016/j.jhep.2006.10.020 Varela M Real MI

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Molecular biomarkers and histological parameters impact on survival and response to first- line systemic therapy of metastatic colorectal cancer patients

.1093/annonc/mdp206 10.1093/annonc/mdp206 Mir O Ropert S Alexandre J Goldwasser F Hypertension as a surrogate marker for the activity of anti- VEGF agents Ann Oncol 2009 20 967 70 10.1093/annonc/mdp206 37 Poole C, Gardiner J, Twelves C, Johnston P, Harper P, Cassidy J, et al. Effect of renal impairment on the pharmacokinetics and tolarebility of capecitabine (Xeloda) in cancer patients. Cancer Chemother Pharmacol 2002; 49: 225-34. doi: 10.1007/s00280-001-4808-0 10.1007/s00280-001-0408-0 Poole C Gardiner J Twelves C Johnston P

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18F-fluorodeoxyglucose and 18F-flumazenil positron emission tomography in patients with refractory epilepsy

–FMZ) have been developed. 55 - 60 Compared to 11 C-FMZ, 18 F-FEFMZ has lower receptor affinity, and higher nonspecific binding due to faster metabolism and faster kinetics. 18 F-FFMZ also has faster kinetics than 11 C-FMZ. Compared to 11 C-FMZ, 18 F-FEF has lower affinity to benzodiazepine receptors, rapid kinetics in the brain and faster metabolism. 55 - 60 18 F-FMZ, with an identical structure to 11 C-FMZ, has been shown to have similar pharmacokinetics and peripheral metabolism and PET imaging characteristics as 11 C-FMZ. 18 F-FMZ has been established as

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Wenetoklaks w leczeniu chorób układu krwiotwórczego i guzów litych

Robak T Pharmacodynamic considerations of small molecule targeted therapy for treating B-cell malignancies in the elderly Expert Opin Drug Metab Toxicol 2015 11 1371 91 [11] Wilson WH, O’Connor OA, Czuczman MS, et al. Navitoclax, a targeted high affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol 2010;11:1149-59. 21094089 10.1016/S1470-2045(10)70261-8 Wilson WH O’Connor OA Czuczman MS et al Navitoclax, a targeted high

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Retrospection of the effect of hydroxyurea treatment in patients with sickle cell disease

pharmacokinetics of HU indicate that the renal impairment results in increased systemic exposure and decreased urinary recovery of the drug [ 16 ]. Some patients receiving HU therapy showed mild albuminuria, with an increase in white cells and granular casts, as well as occasional red cells, in the urine [ 76 ]. However, the BABY HUG trial demonstrated that HU is associated with better urine-concentrating ability and less renal enlargement, in addition to improvement in overall renal function [ 58 ]. Studies in animal models revealed that that HU therapy inhibits spermatogenesis

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Zastosowanie infuzyjnego schematu chemioterapii DA-EPOCH w leczeniu chłoniaków agresywnych

] schedule, and pharmacokinetics would improve outcome in patients with large B-cell lymphomas. A prospective multi-institutional study of administration of etoposide, vincristine, and doxorubicin for 96 hours with bolus doses of cyclophosphamide and oral prednisone (EPOCH therapy. Schemat chemioterapii EPOCH z podaniem leków w dawkach dostosowywanych, z lub bez dodatku rituximabu (DA-EPOCH(-R), dose adjusted -EPOCH - rituximab) jest leczeniem wykorzystującym długotrwałą infuzję cytostatyków, z modyfikacją dawek w kolejnych cyklach na podstawie obserwowanych parametrow

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Progressive arthropathy in the course of immune tolerance induction failure in a child with hemophilia A and FVIII inhibitor – a case report

with hemophilia A with inhibitors: results from the HAVEN 2 study Blood 2018 132 suppl 1 632 (abstr) [13] Pipe SW, Shima M, Lehle M, et al. Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study. Lancet Haematol 2019. Published online April 16, 2019. Pipe SW Shima M Lehle M et al Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre

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Implantoprosthetic rehabilitation of a patient with severe form of hemophilia B: a case report

subcommittee of factor VIII and factor IX of the scientific and standarization committee of the International Society on Thrombosis and Haemostasis Thromb Haemost. 2001 85 560 [4] Lehmann-Kopydlowska M, Zawilska K. Dental guidelines in congenital hemophilia A and B. Czas Stomatol. 2010;63(6):345-357. Lehmann-Kopydlowska M Zawilska K. Dental guidelines in congenital hemophilia A and B Czas Stomatol. 2010 63 6 345 357 [5] Bjorkman S, Carlsson M, Berntop E. Pharmacokinetics of factor IX in patients with haemophilia B: Methodological aspects and physiological interpretation

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Stosowanie leków biopodobnych w hematoonkologii – stanowisko Polskiego Towarzystwa Hematologów i Transfuzjologów

Kanakasetty GB et al Rituximab biosimilar and reference rituximab in patients with previously untreated advanced follicular lymphoma (ASSIST-FL): primary results from a confirmatory phase 3, double-blind, randomised, controlled study Lancet Haematol 2017 4 e350 61 [8] Kim WS, Buske C, Ogura M, et al. Efficacy, pharmacokinetics, and safety of the biosimilar CT-P10 compared with rituximab in patients with previously untreated advanced-stage follicular lymphoma: a randomised, double-blind, parallel-group, non-inferiority phase 3 trial. Lancet Haematol 2017;4:e362

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