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L. Carlucci, K.H. Song, H.I. Yun, H.J. Park, K.W. Seo and M. Giorgi

) Pharmacokinetic/pharmacodynamic modeling in drug research and development. J Clin Pharmacol 40: 1399-1418. Fassler PE, Tranquilli WJ, Paul AJ, Soll MD, DiPietro JA, Todd KS (1991) Evaluation of the safety of ivermectin administered in a beef-based formulation to ivermectin- sensitive Collies. J Am Vet Med Assoc 199: 457-460. Gabrielsson J, Weiner D (2002) Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Swedish Pharmaceutical Press, Stockholm, Sweden. German AJ (2006) The growing problem of obesity in

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A. Burmańczuk, T. Grabowski, T. Błądek, C. Kowalski and P. Dębiak

Drugs. Cephalosporin Drugs. Extralabel Animal Drug Use. Order of Prohibition 735-744. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295364/ Gibaldi M, Perrier D ( 1982 ) Pharmacokinetics. 2nd ed. Marcel Dekker, New York. Grabowski T, Marczak M, Jaroszewski JJ, Whitmire M ( 2012 ) Comparison of bioequivalence study regulatory requirements for human and veterinary drugs. Regul Toxicol Pharmacol 64: 233-242. Gruet P, Maincent P, Berthelot X, Kaltsatos V ( 2001 ) Bovine mastitis and intramammary drug delivery: review and perspectives. Adv Drug Deliv Rev

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H. Ziółkowski, J.J. Jaroszewski, N. Ziółkowska and A. Jasiecka

References Adusumalli VE, Gilchrist JR, Wichmann JK, Kucharczyk N, Sofia RD ( 1992 ) Pharmacokinetics of felbamate in pediatric and adult beagle dogs. Epilepsia 33: 955-960. Adusumalli VE, Yang JT, Wong KK, Kucharczyk N, Sofia RD ( 1991 ) Felbamate pharmacokinetics in the rat, rabbit, and dog. Drug Metab Dispos 19: 1116-1125. Ambrósio AF, Silva AP, Malva JO, Soares-da-Silva P, Carvalho AP, Carvalho CM ( 2001 ) Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of

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Zhaoxiang Zhou, Meng Wang, Zengjun Guo and Xiaoying Zhang

flavonoid, kaempferol on human health and cancer chemoprevention, Food Chem. 138 (2013) 2099-2107; DOI: 10.1016/j.foodchem.2012.11.139. 4. A. Barve, C. Chen, V. Hebbar, J. Desiderio, C. L. Saw and A. Kong, Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats, Biopharm. Drug Dispos. 30 (2009) 356-365; DOI: 10.1002/bdd.677. 5. M. K. Piskula and J. Terao, Quercetin’s solubility affects its accumulation in rat plasma after oral administration, J. Agric. Food Chem. 10 (1998) 4313-4317; DOI: 10.1021/jf980117

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DD Milovanovic, JR Milovanovic, M Radovanovic, I Radosavljevic, S Obradovic, S Jankovic, D Milovanovic and N Djordjevic

Introduction Carbamazepine belongs to the older generation of anticonvulsants, which is almost completely metabolized in the liver through processes that involve several liver enzymes, including CYP2C8 [ 1 - 4 ]. To date, there are 16 different CYP2C8 alleles described http://www.cypalleles.ki.se/cyp2c8.htm ), most of them associated with altered enzyme activity [ 5 ]. Although genes could affect the drug metabolism there is a general lack of evidence of influence of CYP2C8 genetic variations on carbamazepine pharmacokinetics, especially in children [ 6

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S. Yohannes, Md. Akil Hossain, J.Y. Kim, S.J. Lee, D.M. Kwak, J.W. Suh and S.C. Park

References Abo-el-Sooud K, Goudah A (2010) Influence of Pasteurella multocida infection on the pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in rabbits. J Vet Pharmacol Ther 33: 63-68. Albarellos G, Montoya L, Landoni M (2005) Pharmacokinetics of marbofloxacin after single intravenous and repeat oral administration to cats. Vet J 170: 222-229. Boxenbaum H (1980) Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance

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Yuchi Jia

, phosphonomycin amino butyl alcohol three salt granules, and fosfomycin two sodium salt for injection. Although the clinical application of phosphomycin has increased in recent years, there are few clinical reports in China. According to the related literatures at home and abroad, this review briefly introduces fosfomycin in the following three aspects: progress in synthetic methods, pharmacokinetic and pharmacodynamic characteristics, and antibacterial activities, to provide references for clinical rational use. 2 The synthesis of fosfomycin Fosfomycin was first

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A. Di Salvo, M. Giorgi, H.K. Lee, C. Vercelli, F. Rueca, M. Trabalza Marinucci and G. della Rocca

, Giorgi M (2014) Pharmacokinetics of the Novel Cyclooxygenase 2 Inhibitor Cimicoxib in Donkeys. J Equine Vet Sci 34: 923-925. Kim TW, Della Rocca G, Di Salvo A, Ryschanova R, Sgorbini M, Giorgi M (2015) Evaluation of pharmacokinetic and pharmacodynamic properties of cimicoxib in fasted and fed horses. N Z Vet J 63: 92-97. Lees P, Taylor JB, Higgins AJ, Sedgwick AD (1988a) In vitro and in vivo binding of phenylbutazone and related drugs to equine feeds and digesta. Res Vet Sci 44: 50-56. Lees P, Ayliffe T, Maitho TE

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M. Giorgi, S. Del Carlo, B. Łebkowska-Wieruszewska, C. Kowalski and G. Saccomanni

References de Sousa AB, Santos AC, Schramm SG, Porta V, Górniak SL, Florio JC, de Souza Spinosa H ( 2008 ) Pharmacokinetics of tramadol and o-desmethyltramadol in goats after intravenous and oral administration. J Vet Pharmacol Ther 31: 45-51. Elghazali M, Barezaik IM, Abdel Hadi AA, Eltayeb FM, Al Masri J, Wasfi IA ( 2008 ) The pharmacokinetics, metabolism and urinary detection time of tramadol in camels. Vet J 178: 272-277. Garrido MJ, Sayar O, Segura C, Rapado J, Dios-Vieitez MC

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Suvatna Chulavatnatol, Kumthorn Malathum, Sasisopin Kiertiburanakul, Kittisak Sripha and Pojawon Lawanprasert

. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother. 1998; 42:332-8. 5. Hsu A, Granneman GR, Cao G, Carothers L, Japour A, El-Shourbagy T, et al. Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers. Antimicrob Agents Chemother. 1998; 42:2784-91. 6. The United States Pharmacopoeial Convention, Inc. The United States Pharmacopeia 26 / National Formulary 21. Rockville, USA; 2003. 7. Drug Control Division. Thailand Guidelines for the Conduct of