Xianglin Zhang, Fangfang Fan, Yong Huo and Xiping Xu
of hypertension in China and in other populations with similar characteristics.
Sources of Financial Support
Including from the Projects of National Natural Science Foundation of China (grants No. 81473052, 81441091, and 81402735); the Major State Basic Research Development Program of China (973 program) (2012 CB517703); Clinical Center (grant No. zx09401013); National Science and Technology Major Projects Specialized for “Major New Drugs Innovation and Development” during the 12th Five-Year Plan Period: China Stroke Primary Prevention Trial (grant No. zx
prospective, randomized, and multicenter studies are the main research directions in the future. Innovation is needed in the scientific research in TCM. The TCM research that meets the clinical needs, aims to improve the level of prevention and treatment of major diseases in China, will get further developed.
Source of Foundation
The present study was supported by the Special Research Funds for Traditional Chinese Medicine Industry from State Administration of Traditional Chinese Medicine (201407001) and National Natural Science Foundation Project (grant No. 81774092
Mahdi Ghorbani, Benyamin Khajetash, Najmeh Ghatei, Mohammad Mehrpouyan, Ali S. Meigooni and Ramin Shahraini
calculations. Overall radiation time is thus prolonged using this irradiation technique. The I-RSBT could be promising also for some other sites in brachytherapy like gynecology or breast brachytherapy. It is interesting as a subject of further research.
Additionally, the dose distribution around the source in shielded mode is less symmetrical compared to unshielded source which could be accounted as a disadvantage ( Figure 7 ). However this can be compensated in treatment planning. This leads to “Intensity Modulated Brachytherapy” which is considered as an innovation at
Li Ma, Yu Men, Lingling Feng, Jingjing Kang, Xin Sun, Meng Yuan, Wei Jiang and Zhouguang Hui
individualized increments for different patients, and adopting new technologies and new equipment such as new radiation therapy, no consensus has been achieved yet. It is expected that the ongoing clinical trials and explorations for increasing doses of radiotherapy can further improve control rate survival in LANSCLC.
This study was supported by National key research and development program (2017YFC1311000), Beijing Hope Run Special Fund of Cancer Foundation of China (No.LC2016L03), CAMS Innovation Fund (No.2016-I2M-1-011), Clinical Application
Taja Lozar, Klara Gersak, Maja Cemazar, Cvetka Grasic Kuhar and Tanja Jesenko
-derived CTC cultures were first established 134 , though implementation of the procedure into regular clinical practice has proven to be difficult due to the low efficiency of available detection methods as well as prolonged periods needed to establish cell lines. 135 CTC-based patient-derived xenografts represent an innovation in cancer research with the potential to guide therapy or pre-clinical drug testing and biomarker identification. CTCs are isolated from the patient’s blood and injected into immunocompromised animals. Subsequently generated xenografts can be used
Alin-Gabriel Gabor, Cristian Zaharia, Adrian Tudor Stan, Andrei Mihai Gavrilovici, Meda-Lavinia Negruțiu and Cosmin Sinescu
5. Klim J, Corrales E. Innovation in Dentistry: CAD/CAM Restorative Procedures. A Peer-Reviewed Publication. Dent Mater J. 2009;28:44-56.
6. Digital Impression Systems and the Importance of Interoperability. Available at: http://glidewelldental.com/education/inclusive-dental-implant-magazine/volume-5-issue-1/digital-impression-systems-and-the-importance-of-interoperability/
7. Innovation in Dentistry: CAD/CAM Restorative Procedures. Available at: https://www.dentalacademyofce.com/courses/1586/pdf/innovationcad.pdf .
Zahra Mogaddami, Farzam Sheikhzadeh, Homeira Hatami, Seyed Mahdi Banan Khojasteh, Nazli Khajehnasiri, Ali Reza Ali Hemmati and Ali Dastranj
Madrid E, Reyes JG, Hernandez B, Garcia JM, San Martin S, Olivero P, Crespo PV, Parraga M. Effect of normobaric hypoxia on the testis in a murine model. Andrologia 45, 332-338, 2013.
Navarro‐Casado L, Juncos‐Tobarra MA, Chafer‐Rudilla M, Onzono LI, Blazquez‐Cabrera JA, Miralles‐Garcia JM. Effect of experimental diabetes and STZ on male fertility capacity. Study in rats. J Androl 31, 584-592, 2010.
Noble E, Melling J, Shoemaker K, Tikkanen H, Peltonen J, Stuckey M, Petrella RJ. Innovation to reduce cardiovascular complications of diabetes
Ario Santini, Leonard Azamfirei and Cosmin Moldovan
privileged position to benefit the practice and delivery of medicine.
The concern of the peer review process is to identify and suggest for publication, manuscripts that are authoritative and contribute to the advancement of medical practice. In turn, these papers become the foundation for further research and the basis of day-to-day medical practices. It is central to medical research in that it appraises studies for competence, importance, and innovation by experienced experts in a particular field of study. The process is frequently an essential determinant of an
Paweł Łaguna, Anna Klukowska, Jarosław Ćwikła and Michał Matysiak
. Haemophilia 2006;12:102–10.
Escuriola Ettingshausen C Kreuz W Recombinant vs plasma-derived products, especially those with intact VWF regarding inhibitor development. Haemophilia 2006 12 102 10
 Hartmann J, Croteau SE. 2017 Clinical trials update: Innovations in hemophilia therapy. Am J Hematol 2016; 91:1252–60.
Hartmann J Croteau SE. 2017 Clinical trials update: Innovations in hemophilia therapy Am J Hematol 2016; 91 1252 60
 Oldenburg J, Mahlangu JN, Kim B, et al. Emicizumab prophylaxis in hemophilia A with inhibitors. N Engl
Iwona Hus, Joanna Drozd-Sokołowska, Lidia Gil, Ewa Lech-Marańda, Krzysztof Giannopoulos, Sebastian Giebel, Wojciech Jurczak, Tomasz Wróbel, Jan Maciej Zaucha and Tadeusz Robak
biologicznego innym jest różna. Podczas gdy w większości państw nie jest możliwa automatyczna substytucja, w Polsce nie jest ona zabroniona. Wynika to najpewniej z braku jakiegokolwiek dokumentu regulującego zasady zastępowalności leków referencyjnych lekami biopodobnymi. W efekcie zarówno Ministerstwo Zdrowia, jak i Narodowy Fundusz Zdrowia propagują pełną zamienialność leków biologicznych z tą samą molekułą. W Stanach Zjednoczonych Biologics Price Competition and Innovation Act (BPCIA) również dopuszcza automatyczną substytucję leków biologicznych uznanych przez FDA za