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2016 Revision to the WHO classification of acute lymphoblastic leukemia

.48.9377 Moorman AV Robinson H Schwab C Richards SM Hancock J Mitchell CD et al Risk-directed treatment intensification significantly reduces the risk of relapse among children and adolescents with acute lymphoblastic leukemia and intrachromosomal amplification of chromosome 21: a comparison of the MRC ALL97/99 and UKALL2003 trials J Clin Oncol 2013 31 3389 96 7 Den Boer ML, van Slegtenhorst M, De Menezes RX, Cheok MH, Buijs-Gladdines JG, Peters ST, et al . A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

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Mathematical model to predict methotrexate elimination in children with acute lymphoblastic leukemia

. Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia. 2010;24(2):345-54. DOI: 10.1038/leu.2009.251 12. Mitchell C, Richards S, Harrison CJ, Eden T. Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001. Leukemia. 2010;24(2):406-18. DOI: 10.1038/leu.2009.256 13. Evans WE, Relling MV, Rodman JH, Crom WR, Boyett JM, Pui CH. Conventional compared with individualized chemotherapy for childhood acute

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Selected Aspects of Angiogensis in Haematological Malignancies

and myelodysplastic syndromes. Blood 2000; 96(6): 2240-2245. [4] AVRAMIS IA, PANOSYAN EH, DOREY F, HOLCENBERG JS, AVRAMIS VI. Children's Oncology Group., Correlation between high vascular endothelial growth factor-A serum levels and treatment outcome in patients with standard-risk acute lymphoblastic leukemia: a report from Children's Oncology Group Study CCG-1962. Clin Cancer Res 2006; 12(23): 6978-6984. [5] BACHELDER RE, CRAGO A, CHUNG J, WENDT MA, SHAW LM, ROBINSON G, MERCURIO AM. Vascular endothelial growth factor is an autocrine

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Perforacja jelit jako powikłanie chemioterapii ostrej białaczki limfoblastycznej u dzieci – opis dwóch przypadków

acute lymphoblastic leukemia. Med Sci Monit 2015;21:1656–61. 10.12659/MSM.893142 Yang L Yu L Chen X Hu Y Wang B Clinical analysis of adverse drug reactions between vincristine and triazoles in children with acute lymphoblastic leukemia Med Sci Monit 2015 21 1656 – 61 [11] Ceppi F, Langlois-Pelletier C, Gagné V, et al. Polymorphisms of the vincristine pathway and response to treatment in children with childhood acute lymphoblastic leukemia. Pharmacogenomics 2014;15(8):1105–16. 10.2217/pgs.14.68 Ceppi F Langlois-Pelletier C Gagné V et al

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Chemotherapy induced liver toxicity in children with malignant diseases

(3):161-166. 9. Schmiegelow K., Pulczynska M. – Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia. Br J Cancer, 1990, 61(5):767-72. 10. Ballauff A., Krahe J., Jansen B., et al. – Chronic liver disease after treatment of malignancies in children. Klin Pediatr, 1999, 211(2):49-52. 11. Elbarbary N.S., Ismail E.A., Farahat R.K., et al. – ω-3 fatty acids as an adjuvant therapy ameliorates methotrexateinduced hepatotoxicity in childern and adolescents with acute lymphoblastic leukemia: A randomized

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Polymorphism of Biotransformation Genes and Risk of Relapse in Childhood Acute Leukemia

References Wood ME, Philips GK. Hematology/Oncology Secrets. 3rd ed. Philadelphia: Hanley & Belfus Inc., 2003. Chan KW. Acute lymphoblastic leukemia. Curr Probl Pediatr Adolesc Health Care 2002; 32(2): 40-49. Ansari M, Krajinovic M. Pharmacogenomics of acute leukemia. Pharmacogenomics 2007; 8(7): 817-834. Seeger K, Adams HP, Buchwald D, Beyermann B, Kremens B, Niemeyer C, Ritter J, Schwabe D, Harms D, Schrappe M, Henze G. TEL-AML1 fusion transcript in

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Biochemical aspects of KB-28 compound on physically loaded study subjects


In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the experiment. The objective of the current study was to characterize the effects of KB-28 compounds on carbohydrate and lipid exchange indices under the conditions of physical load as a possible mechanism of actoprotective effect. In the course of the experiment, the indices of carbohydrate and lipid exchange in the muscle, blood and liver of animal models were determined following a 15-day physical load course. In doing so, glucose, glycogen and total lipid concentrations were assessed. The KB-28 compound was administered daily at levels determined during the course of regular physical load normalized metabolic processes in rats. The results were then compared to a control which received intraperitoneally the equivolume 0.9% sodium chloride solution. The phenomenon of actoprotection consisted in enhancing concentrations of glycogen in skeletal muscles and liver. Compared to the control figures, this increase was 28.8% and 25.0%, accordingly. Moreover, the course of KB-28 caused a statistically significant reduction (by 32.1%) of the total serum lipid concentration in the animals under physical load. The effect may be a sign of the ability of this substance to utilize active lipolysis for improvement of the skeletal muscle performance. Having analyzed the results obtained, we can draw a conclusion that influencing the biochemical processes in the study models is one of the mechanisms of the KB-28 actoprotective effect.

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Infant acute leukemia with lineage switch at relapse expressing a novel t(4;11)(q21;q23) MLL-AF4 fusion transcript

References 1. De Braekeleer E, Douet-Guilbert N, Le Bris MJ, Basinko A, Morel F, De Braekeleer M. Gene expression profiling of adult t(4;11)(q21;q23)-associated acute lymphoblastic leukemia reveals a different signature from pediatric cases. Anticancer Res. 2012 Sep;32(9):3893-9 2. De Braekeleer M, Morel F, Le Bris MJ, Herry A, Douet-Guilbert N. The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia. Anticancer Res. 2005 May-Jun;25(3B):1931-44 3. Drexler HG, Quentmeier H

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Killer Cell Immunoglobulin-Like Receptor Genes Polymorphisms in Macedonian Patients with Haematological Malignancies

;16(4):533-42. 17. Babor F, Manser A, Schönberg K, Enczmann J, Borkhardt A, Meisel R, Uhrberg M. Lack of association between KIR genes and acute lymphoblastic leukemia in children. Blood. 2012;120(13): 2770-2 18. Towner P. Purification of DNA. Essential Molecular Biology T. A. Brown. Oxford, Oxford University Press, 1995:47-54. 19. Spiroski M, Arsov T, Petlichkovski A, Strezova A, Trajkov D, Efinska-Mladenovska O, Zaharieva E. Case Study: Macedonian Human DNA Bank (hDNAMKD) as a source for public health Genetics. Health Determinants in the Scope of

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Family-based Association Study of Killer Cell Immunoglobulin-Like Receptor Genes with Leukemia

polymorphisms in non-Hodgkin lymphoma: possible association with clinical course. Leuk Lymphoma, 2015, 56(10), 2902-7. 17. Sullivan EM, Jeha S, Kang G, et al. NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate with postinduction residual disease. Clin Cancer Res, 2014, 20(23), 5986-94. 18. Misra MK, Prakash S, Moulik NR, et al. Genetic associations of killer immunoglobulin like receptors and class I human leukocyte antigens on childhood acute lymphoblastic leukemia among north Indians. Hum Immunol, 2016, 77(1), 41-6. 19

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