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Frequencies of Single-Nucleotide Polymorphisms and Haplotypes of the SLCO1B1 Gene in Selected Populations of the Western Balkans

- etics is associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1). Br J Clin Pharmacol. 2005; 59(5): 602-604. 4. Niemi M, Backman JT, Kajosaari LI, Leathart JB, Neuvonen M, Daly AK, et al. Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics. Clin Pharmacol Ther. 2005; 77(6): 468-478. 5. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the phar-macokinetics of atorvastatin and rosuvastatin. Clin Phar-macol Ther. 2007; 82

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Elimination of Chloramphenicol in Rainbow Trout Receiving Medicated Feed

References Cannon M, Harford S, Davies J. A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives. J Antimicrob Chemother 1990;26:307-17. World Health Organization (WHO). Toxicological evaluation of certain veterinary drug residues in food. WHO Food Additives Series 53. Geneva: WHO; 2004. Anadón A, Bringas P, Martinez-Larrañaga MR, Diaz MJ. Bioavailability, pharmacokinetics and residues of chloramphenicol in the chicken. J Vet

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Changes In Liver and Brain Cytochrome P450 after Multiple Cocaine Administration, Alone and in Combination with Nifedipine

References Filip M, Frankowska M, Zaniewska M, Golda A, Przegalinski E. The serotonergic system and its role in cocaine addiction. Pharmacol Rep 2005;57:685-700. Sun L, Lau CE. Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzoylecgonine, after intravenous and oral administration in rats. Drug Metab Dispos 2001;29:1183-9. Arinc E, Bozcaarmutlu A. Catalyzation of cocaine N-demethylation by cytochromes P4502B, P4503A, and P4502D in fish

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Red Blood Cell Acetylcholinesterase and Plasma Butyrylcholinesterase Status: Important Indicators for the Treatment of Patients Poisoned by Organophosphorus Compounds

;107:233-9. Worek F, Reiter G, Eyer P, Szinicz L. Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Arch Toxicol 2002;76:523-9. Eyer P. Optimal oxime dosage regimen, a pharmacokinetic approach. In: Szinicz L, Eyer P, Klimmek R, editors. Role of Oximes in the Treatment of Anticholinesterase Agent Poisoning. Heidelberg. Berlin, Oxford: Spektrum Akademischer Verlag; 1996. p. 33-51. Eyer P. Use of obidoxime in OP poisoning. Hum Exp Toxicol 1996

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Nifedipine Lowers Cocaine-Induced Brain and Liver Enzyme Activity and Cocaine Urinary Excretion in Rats

multiple administration in rats. In: Tonev S, Kanev K, Dishovsky C, editors. Medical management of chemical and biological casualties. Sofia: Publishing house IRITA; 2009. p. 274-80. Drocourt L, Pascussi JM, Assenat E, Fabre JM, Maurel P, Vilarem MJ. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP 3A, CYP 2B and CYP 2C in human hepatocytes. Drug Metab Dispos 2001;29:1325-31. Sun L, Lau CE. Simultaneous pharmacokinetic modeling of cocaine and its

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Genetic polymorphisms of CYP2C9, CYP2C19, and CYP3A5 in Kosovar population

References 1. Lam TN, Hunt CA. Mechanistic insight from in silico pharmacokinetic experiments: roles of P-glycoprotein, Cyp3A4 enzymes, and microenvironments. J Pharmacol Exp Ther 2010;332:398-412. doi: 10.1124/pr.110.003533 2. Preissner SC, Hoffmann MF, Preissner R, Dunkel M, Gewiess A, Preissner S. Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy. PloS One 2013;8(12):e82562. doi: 10.1371/journal.pone.0082562 3. Kantae V, Krekels EH, Esdonk MJ, Lindenburg P, Harms AC, Knibbe

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Dioxins and Human Toxicity

,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites. Lancet 2009;374:1179-85. World Health Organization (WHO). Dioxins and their effects on human health [displayed 12 November 2010]. Available at http://www.who.int/mediacentre/factsheets/fs225/en/index.html Olson, J. R. Pharmacokinetics of dioxin and related chemicals. In Dioxins and Health. A. Schecter, ed. New York, NY: Plenum Press; 1994. p. 163-167. Pirkle JL, Wolfe WH, Patterso DG

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Evaluation of Oxime K203 as Antidote in Tabun Poisoning

colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1960;7:88-95. Thiermann H, Mast U, Klimmek R, Eyer P, Hibler A, Pfab R, Flegenhauer N, Zilker T. Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum Exp Toxicol 1997;16:473-80. Eddleston M, Szinicz L, Eyer P, Buckley N. Oximes in acute organophosphorus pesticide poisoning: a systemic review of clinical trials. Qjm-Mon J Assoc Phys 2002

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Cytogenetic Study on Workmen Occupationally Exposed to Pesticides

associated para oxonase: inhibition of the biological activity of minimally oxidized low-density lipoprotein. J Clin Invest 1995; 96: 2882-2891. Timchalk C, Poet TS, Kousba AA. Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos. Toxicology 2006; 220: 13-25 WHO. (2007) WHO Specifications and Evaluations for Public Health Pesticides. Chlorpyrifos. World Health Organization, p.17. www

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Cholinesterases: Structure, Role, and Inhibition

blood cholinesterases by the Ellman method. Arh Hig Rada Toksikol 2000;51:13-8. Thiermann H, Mast U, Klimmek R, Eyer P, Hibler A, Pfab R, Flegenhauer N, Zilker T. Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum Exp Toxicol 1997;16:473-80. Velan B, Kronman C, Ordentlich A, Flashner Y, Leitner M, Cohen S, Shafferman A. N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis. Biochem J 1993

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