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Effect of Food on the Pharmacokinetics of Gliclazide 60 mg Modified Release Tablet in Healthy Caucasian Volunteers

, Lewis BC, et al. Identification of the human cytochromes P450 catalyzing the rate-limiting pathways of gliclazide elimination. Br J Clin Pharmacol. 2007;64(4):450-7. 15. Todor I, Muntean D, Neag M, et al. The influence of CYP2D6 phenotype on the pharmacokinetic profile of atomoxetine in Caucasian healthy subjects. Acta Medica Marisiensis. 2017;63(2):73-9. 16. Rojanasthien N, Autsavakitipong T, Kumsorn B, et al. Bioequivalence study of modified-release Gliclazide tablets in healthy volunteers. ISRN Pharmacol. 2012;2012. doi:10.5402/2012/375134. 17

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Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study

References 1. de Boer V.C., Dihal A.A., van der Woude H., Arts I.C., Wolffram S., Alink G.M., Rietjens I.M., Keijer J., Hollman P.C.: Tissue distribution of quercetin in rats and pigs. J Nutrit 2005, 135, 1718–1725. 2. Chang L., Ren Y., Cao L., Sun Y., Sun Q., Sheng N., Yuan L., Zhi X., Zhang L.: Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC–MS/MS. J Chrom B 2012, 904, 59–64. 3. Coppin J.P., Xua Y., Chena H., Pan M.H., Hoc Ch.T., Juliani R., Simon J.E., Wu Q

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The Monitoring of Immunosuppressive Therapy with Tacrolimus in Patients with Kidney Transplant, Based on the Pharmacokinetic Criteria

transplantation. Prilozi 2011;32:87-103. 12. Naesens M, Kuypers DRJ, Sarwal M. Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol 2009;4:481–508. 13. Michael F. Crutchlow, Roy D. Bloom. Transplant-associated hyperglycemia: A new look at an old problem.Clin J Am Soc Nephrol 2007;2:343–355. 14. Pirsch J, Bekersky I, Vincenti F et al. Coadministration of tacrolimus and mycophenolate mofetil in stable kidney transplant patients: pharmacokinetics and tolerability. J Clin Pharmacol 2000;40:527-532. 15. Hasselink DA, Ngyuen H, Wabbijin M et al

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The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients

Introduction Carbamazepine belongs to the older generation of anticonvulsants, which is almost completely metabolized in the liver through processes that involve several liver enzymes, including CYP2C8 [ 1 - 4 ]. To date, there are 16 different CYP2C8 alleles described ), most of them associated with altered enzyme activity [ 5 ]. Although genes could affect the drug metabolism there is a general lack of evidence of influence of CYP2C8 genetic variations on carbamazepine pharmacokinetics, especially in children [ 6

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The progress in study of fosfomycin

, phosphonomycin amino butyl alcohol three salt granules, and fosfomycin two sodium salt for injection. Although the clinical application of phosphomycin has increased in recent years, there are few clinical reports in China. According to the related literatures at home and abroad, this review briefly introduces fosfomycin in the following three aspects: progress in synthetic methods, pharmacokinetic and pharmacodynamic characteristics, and antibacterial activities, to provide references for clinical rational use. 2 The synthesis of fosfomycin Fosfomycin was first

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Bioequivalence of indinavir capsules in healthy volunteers

. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother. 1998; 42:332-8. 5. Hsu A, Granneman GR, Cao G, Carothers L, Japour A, El-Shourbagy T, et al. Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers. Antimicrob Agents Chemother. 1998; 42:2784-91. 6. The United States Pharmacopoeial Convention, Inc. The United States Pharmacopeia 26 / National Formulary 21. Rockville, USA; 2003. 7. Drug Control Division. Thailand Guidelines for the Conduct of

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Withdrawal of amoxicillin and penicillin G procaine from milk after intramammary administration in dairy cows with mastitis

References 1. Bengtsson B., Jacobsson S.O., Luthman J., Franklin A.: Pharmacokinetics of penicillin-G in ewes and cows in late pregnancy and in early lactation. J Vet Pharmacol Ther 1997, 20, 258–261. 2. Błądek T, Posyniak A, Gajda A, Gbylik M, Żmudzki J.: Multi-class procedure for analysis of antibacterial compounds in animal tissues by liquid chromatography tandem mass spectrometry. Bull Vet Inst Pulawy 2011, 55, 741–748. 3. Bruno F., Curini R., di Corcia A., Nazzari M., Samperi R.: Solid-phase extraction followed by liquid chromatography

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Comparison of oral bioavailability of acetaminophen tablets, capsules and effervescent dosage forms in healthy volunteers

.: Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur J Clin Pharm. 1977;11:283. 9. Srinath K, et al.: Formulation and evaluation of effervescent tablets of paracetamol. INT J Pharm Res Dev. 2011;3:76. 10. Blagden N, et al.: Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Adv Drug Deliv Rev 2007 Jul 30;59(7):617-30 Epub 2007 May 29. 11. De Silva L, et al.: Usability of mobile technology to screen for drugdrug interactions in kidney transplant patients. Am J Nephrol

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Pharmacokinetic - pharmacodynamic model and ampicillin residue depletion after intramammary administration in cows

., Marosevic D., Jaglic Z.: Prevalence of mastitis pathogens in milk from clinically healthy cows. Med Weter 2013, 58, 567–575. 4. Christensen J.M., Smith B.B., Murdena S.B., Hollingshead N.: The disposition of five therapeutically important antimicrobial agents in llamas. J Vet Pharmacol Ther 1996, 19, 43–438. 5. Concordet D., Toutain P.L.: The withdrawal time estimation of veterinary drugs revisited. J Vet Pharmacol Ther 1997, 20, 380–386. 6. Craigmill A.L., Pass M.A., Wetzlich S.: Comparative pharmacokinetics of AMX administered intravenously to sheep

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Bioequivalence study of cefepime intramuscular injection

References 1. Mutnick AH, Rhomberg PR, Sader HS, Jones RN. Antimicrobial usage and resistance trend relationships from the MYSTIC Programme in North America (1999-2001). J Antimicrob Chemother. 2004; 53:290-6. 2. Barradell LB, Bryson HM. Cefepime: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1994; 47:471-505. 3. Yahav D, Paul M, Fraser A, Sarid N, Leibovici L. Efficacy and safety of cefepime: a systematic review and meta-analysis. Lancet Infect Dis. 2007; 7

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