Donatella Verbanac, Željan Maleš and Karmela Barišić
. Prescilio and M. R. de Oliveira, Resveratrol and brain mitochondria: a review, Mol. Neurobiol. 55 (2018) 2085–2101; https://doi.org/10.1007/s12035-017-0448-z
55. I. Kang, M. Okla and S. Chung, Ellagic acid inhibits adipocyte differentiation through coactivator-associated arginine methyltransferase 1-mediated chromatin modification, J. Nutr. Biochem. 25 (2014) 946–953.
56. M. Parnham and D. Verbanac, Mild Plants and Dietary Immunomodulators , in Principles of Immunopharmacology, 3rd ed. (Eds. F. Nijkamp, M. Parnham), Springer Basel AG, Basel 2011
I. Kazimierová, L. Pappová, M. Šútovská and S. Fraňová
 Bossé Y. Asthmatic airway hyperresponsiveness: the ants in the tree. Trends in Molecular Medicine. 2012; 18: 627-633.
 Brown A, Danielsson J, Townsend EA, et al. Attenuation of airway smooth muscle contractility via flavonol-mediated inhibition of phospholipase-Cβ. Am J Physiol Lung Cell Mol Physiol. 2016; 310:L747-L758.
 Franova S, Joskova M, Sadlonova V, Pavelcikova D, Mesarosova L, Novakova E, Sutovska M. Experimentalmodel of allergic asthma. Advances in Experimental Medicine and Biology. 2013; 756: 49-55.
J. Sutovsky, M. Kocmalova, M. Benco, I. Kazimierova, L. Pappova, A. Frano and M. Sutovska
molecular mechanisms of bone remodeling. J Biol Chem. 2010;285:25103-25108.
 Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol 2014;10:44-56.
 Wuertz K, Haglund L. Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain. Global Spine 2013;J 3:175–184.
Londiwe Simphiwe Mbatha, Fiona Chepkoech Maiyo and Moganavelli Singh
, M. Ogris and L. W. Seymour, Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells, Nucleic Acids Res. 29 (2001) 3882–3891; https://doi.org/10.1093/nar/29.18.3882
26. H. Kang, R. DeLong, M. H. Fisher and R. L. Juliano, Tat-conjugated PAMAM dendrimers as delivery agents for antisense and siRNA oligonucleotides, Pharm. Res. 22 (2005) 2099–2106; https://doi.org/10.1007/s11095-005-8330-5
27. R. B. Kolhatkar, K. M. Kitchens, P. W. Swaan and H. Ghandehari, Surface acetylation of polyamidoamine
Aleksandra Kapedanovska Nestorovska, Krume Jakjovski, Zorica Naumovska, Zoran Sterjev, Nadica Matevska Geskovska, Kristina Mladenovska, Ljubica Suturkova and Aleksandar Dimovski
19. T. S. Tracy, A. S. Chaudhry, B. Prasad, K. E. Thummel, E. G. Schuetz, X. B. Zhong, Y. C. Tien, H. Jeong, X. Pan, L. M. Shireman, J. Tay-Sontheimer and Y. S. Lin, Interindividual variability in cytochrome P450-mediated drug metabolism, Drug Metab. Dispos . 44 (2016) 343–351; https://doi.org/10.1124/dmd.115.067900
20. J. Kirchheiner and J. Brockmöller, Clinical consequences of cytochrome P450 2C9 polymorphisms, Clin. Pharmacol. Ther . 77 (2005) 1–16; https://doi.org/10.1016/j.clpt.2004.08.009
21. A. S
Akinleye Akinrinde, Trevor Koekemoer, Maryna Van De Venter and Graeme Bradley
accumulation in 3T3-L1 pre-adipocytes, J. Pharm. Pharmacol. 68 (2016) 107-118; https://doi.org/10.1111/jphp.12485
27. M. Lonn, K. Mehlig, C. Bengtsson and L. Lissner, Adipocyte size predicts incidence of type 2 diabetes in women, FASEB J. 24 (2010) 326-331; https://doi.org/10.1096/fj.09-133058
28. A. J. Alonso-Castro and L. A. Salazar-Olivo, The anti-diabetic properties of Gazuma ulmifolia Lam. are mediated by the stimulation of glucose uptake in normal and diabetic adipocytes without inducing adipogenesis, J. Ethnopharmacol. 118 (2008) 252
of drugs, Adv. Drug Deliv. Rev. 47 (2001) 65-81; DOI: 10.1016/S0169-409X(00)00122-8.
M. S. Wadhwa and K. G. Rice, Receptor mediated glycotargeting, J. Drug Target. 11 (2003) 255-268; DOI: 10.1080/10611860310001636557.
J. Shao and J. K. H. Ma, Characterization of mannosylphospholipid liposome system for drug targeting to alveolar macrophages, J. Drug Deliv. Target. Ther. Agents 4 (1997) 43-48.
Y. Gabr, N. Assem, A. Micheal and L. Fahmy, Evaluation studies on oxypolygelatin and
Nouf M. Al-Rasheed, Laila Fadda, Hala A. Attia, Iman A. Sharaf, Azza M. Mohamed and Nawal M. Al-Rasheed
The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of immuno-inflammatory mediators and heat shock protein expressions in sodium nitrite induced hypoxia in rat lungs. The results revealed that NaNO2 injection caused a significant decrease in Hb in rats, while serum levels of TNF-α, IL-6 and CRP, VEGF and HSP70 were elevated compared to the control group. Administration of melatonin, quercetin or their combination before NaNO2 injection markedly reduced these parameters. Histopathological examination of the lung tissue supported these biochemical findings. The study suggests that melatonin and/or quercetin are responsible for lung tissue protection in hypoxia by downregulation of immuno-inflammatory mediators and heat shock protein expressions. Pre-treatment of hypoxic animals with a combination of melatonin and quercetin was effective in modulating most of the studied parameters to near-normal levels.
Sanaa K. Bardaweel, Rana Abu-Dahab and Nour F. Almomani
In the present study, cytotoxic effects of D-Ala, D-Pro and D-Lys are demonstrated. In an effort to study the possible mechanisms of the observed cytotoxicity, catalase activity, H2O2 generation, and apoptotic activity were measured in HeLa and MCF-7 cell lines. Although D-Lys is a poor substrate for DAO and therefore low H2O2 was detected, it was shown to provoke severe impairment of cellular integrity and survival. Interestingly, a very good substrate for DAO, such as D-Pro, did not substantially reduce cell viability. On the other hand, a moderate substrate for DAO, represented by D-Ala, was shown to moderately trigger toxicity in the tested cell lines. Although a correlation between the in vitro cytotoxicity of D-amino acids and the amount of H2O2 produced was absent, there was a good agreement between the ability of D-amino acids to trigger apoptosis and to provoke toxicity. Our results indicate that the toxicity of D-amino acids does not appear to be solely mediated by H2O2. Therefore, we hypothesize that other possible contributing apoptosis-mediated pathways might cause the observed toxicity.
Sanaa K. Bardaweel, Husam A. Alsalamat, Shereen M. Aleidi and Rasha M. Bashatwah
Extensive in vitro studies have been conducted to evaluate the anticancer activity of oral hypoglycemic agents. Many of these studies experienced detrimental limitations, since they were conducted on cancer cells commonly grown in culture media consisting of extremely high concentrations of growth factors and glucose. The present study was aimed at exploring the antiproliferative effects of the commonly studied metformin and the less frequently reported phenformin oral hypoglycemic agents on different molecular subtypes of breast cancer under rich glucose and glucose deprived conditions. Our results indicate that under glucose deprived conditions, which better reflect the factual glucose-starved solid tumors in vivo, biguanides exert more antiproliferative activities against the three molecular subtypes of breast cancer cell lines examined in this study. In addition, the observed antiproliferative activities of biguanides appear to be mediated by apoptosis induction in breast cancer cells. This induction is significantly augmented under glucose deprived conditions.