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Sebastian Adeberg, Denise Bernhardt, Semi B. Harrabi, Nils H. Nicolay, Juliane Hörner-Rieber, Laila König, Michael Repka, Angela Mohr, Amir Abdollahi, Klaus-Josef Weber, Juergen Debus and Stefan Rieken

ATP production, induction of cell cycle arrest, autophagy, and apoptotic processes through activation of adenosine-5’-monophosphate-activated protein kinase (AMPK) 5 and inhibition of the mTOR (mammalian target of rapamycin) pathway in glioblastoma cells. 6 , 7 AMPK is a serine/threonine kinase that functions as a cellular energy sensor. AMPK is an obligate heterotrimer, consisting of one catalytic subunit (α) and two regulatory subunits (β and γ). 8 Under cellular stress conditions, AMPK is activated by increased AMP-to-ATP ratios to promote catabolism and

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Theodora Benedek and Mariann Gyöngyösi

References 1. Kern KB. Optimal Treatment of Patients Surviving Out-of- Hospital Cardiac Arrest. JACC Cardiovasc Interv. 2012;5:597-605. 2. Steg G, James SK, Atar D, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology. Eur Heart J. 2012;33:2569-619. 3. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of

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Jasna Jevdjic, Filip Zunic and Bojan Milosevic

References 1. Atwood C, Eisenberg MS, Herlitz J, Rea TD. Incidence of EMS-treated out-of-hospital cardiac arrest in Europe. Resuscitation 2005; 67:75-80. 2. Nurnberger A, Sterz F, Malzer R, et al. Out of hospital cardiac arrest in Vienna: Incidence and outcome. Resustitation 2013; 84:42-47. 3. Adrie C, Adib-Conquy M, Laurent I et al. Successful cardiopulmonary resuscitation after cardiac arrest as a “sepsis-like” syndrome. Circulation 2002;106:562-8. 4. Nolan JP, Soar J, Cariou A, Cronberg T

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Bărcan Andreea, Rat Nora and Orzan Marius

References 1. Schwartz BG, Kloner RA, Thomas JL, et al - Therapeutic hypothermia for acute myocardial infarction and cardiac arrest. Am J Cardiol. 2012 Aug 1;110(3):461-6. 2. Luscombe Mark, Andrzejowsk John - Clinical applications of induced hypothermia. Contin Educ Anaesth Crit Care Pain, 2006, 6(1):23-27, doi: 10.1093/bjaceaccp/mki0. 3. Katz LM, Frank JE, Glickma1. n LT, Jr GM, Lambdrt BH, Gordon CJ. Effect of a Pharmacologically Induced Decrease in Core Temperature in Rats Resuscitated from Cardiac Arrest

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Jana Heczková and Alan Bulava

REFERENCES 1. Berdowski J, Berg RA, Tijssen JG, Koster RW. Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies. Resuscitation, 2010; 81(11): 1479-1487. 2. Grasner JT, Lefering R, Koster RW, et al. EuReCa ONE-27 Nations, ONE Europe, ONE Registry: A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation. 2016;105: 188-195. 3. Nishiyama C, Brown SP, May S, et al. Apples to apples or apples to oranges? International variation

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Patrycja Misztal-Okońska, Mariusz Goniewicz, Magdalena Młynarska, Wojciech Krawczyk and Monika Butryn

defibrillator installation in urban areas with similar incidence of public out-of-hospital cardiac arrest: a retrospective registry-based study. BMJ Open. 2017;7(5):e014801. 25. Deakin CD, Shewry E, Gray HH. Public access defibrillation remains out of reach for most victims of out-of-hospital sudden cardiac arrest, Heart 2014; 100 (8): 619-23. 26. Salciccioli JD, Marshall DC, Sykes M, et al. Basic life support education in secondary schools: a cross-sectional survey in London, UK BMJ Open 2017; 7: e011436. 27. Cacko A, Wyzgał A, Galas A, et al. Dostępność

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Ana Radovanovic

Altern Med 2013;13: 212. 65. Aziz AFA, Iqbal M. Antioxidant activity and phytochemical composition of Cynometra cauliflora. J Exp Integr Med 2013; 3(4): 337-41. 66. Kretschmer N, Rinner B, Deutsch AJ, et al. Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma Cells. J Nat Prod 2012;75(5): 865-9. 67. Seshadri P, Rajaram A, Rajaram R. Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes. Free Radic Biol Med 2011; 51

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M. Perian, M. Mărginean, D. Dobreanu and Alina Scridon

;38:745-749. 7. Minasian SM, Galagudza MM, Dmitriev YV, Kurapeev DI, Vlasov TD. Myocardial protection against global ischemia with Krebs-Henseleit bufferbased cardioplegic solution. J Cardiothorac Surg. 2013;8:60. 8. Nakamura Y, Taremoto N, Kuroda H, Ohgi S. The advantages of normocalcemic continuous warm cardioplegia over low calcemic cardioplegia in myocardial protection. Surg Today. 1999;29:884-889. 9. Tevaearai HT, Eckhart AD, Shotwell KF, Wilson K, Koch WJ. Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene

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Radica Živković Zarić, Marijana Stanojević Pirković and Nedim Hamzagić

cycle checkpoint signaling: Cell cycle arrest versus apoptosis. Toxicology. 2002;181:475-81. 23. Luo Z, Yu L, Yang F, Zhao Z, Yu B, Lai H, Wong KH, Ngai SM, Zheng W, Chen T. Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase. Metallomics. 2014;6(8):1480-90. 24. Thota S, Rodrigues DA, Crans DC, Barreiro EJ. Ru (II) compounds: next-generation anticancer metallotherapeutics?. J Med Chem. 2018;61(14):5805-21. 25. Zheng K, Wu Q, Wang C, Tan W, Mei W. Ruthenium(II) Complexes as Potential

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Mojtaba Rad and Mostafa Rad

weight of rescuer and quality of chest compression during cardiopulmonary resuscitation. J PhysiolAnthropol 2014; 24;33:16. doi: 10.1186/1880-6805-33-16. https://doi.org/10.1186/1880-6805-33-16 4. Williams B, Boyle M, Gutwirth H. Rescuer Fatigue in Cardiopulmonary Resuscitation: A Review of the Literature. Australas JParamed 2012;7(4):4. 5. Abella BS, Alvarado JP, Myklebust H, Edelson DP, Barry A, O'Hearn N, et al. Quality of cardiopulmonary resuscitation during in-hospital cardiac arrest. Jama 2005;293(3):305-10. https://doi.org/10.1001/jama.293