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Does the MTHFR A1298C Polymorphism Modulate the Cardiorespiratory Response to Training?

birth defects ( Kluijtmans et al., 1997 ). A second common MTHFR polymorphism is an adenosine to cytosine transversion at nucleotide position 1298 (A1298C, rs1801131) that results in a glutamate to alanine substitution within C-terminal, Sadenosylmethionine (SAM) regulatory domain of the protein ( Weisberg et al., 1998 ). It has been observed that individuals with the 1298 CC genotype have approximately 60 percent specific wild-type in vitro MTHFR activity ( van der Put et al., 1998 ). It suggests that both mutant 677T and 1298C alleles of the MTHFR C677T and A1298C

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Skeletal Muscle Cell Damage Indicators in Volleyball Players after the Competitive Phase of the Annual Training Cycle

of events, which seem to include muscle rupture due to myofibril injury (rupture of myofibrils), impaired excitation-contraction coupling associated with local ATP depletion, changes in the intracellular calcium homeostasis, oxidative stress and inflammation ( Nikolaidis et al., 2008 ). On the other hand, accumulation of reactive oxygen and nitrogen species (RONS), and cytokines stimulate changes in cell signaling and gene expression, which may contribute to adaptive responses to contractile activity, including changes in stress protein expression and upregulation

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The effect of the MTHFR C677T mutation on athletic performance and the homocysteine level of soccer players and sedentary individuals

, and stored in a red top test tube (flat tube) and a purple test tube (EDTA-containing tube). The red test tube that did not contain anticoagulant was used for the analysis of serum total cholesterol, triglyceride, HDL cholesterol, Hcy, folate and vitamin B12. The blood was centrifuged and the serums were separated from the cells to be analyzed. The blood specimen in the purple test tube containing the hemogram EDTA was analyzed on the same day using the blood cell count machine. For the MTHFR C677T mutation and analysis, DNA samples were obtained from the EDTA

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Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study

effects of L. helveticus Lafti® L10 supplementation on the oxidative status markers, along with the biochemical profile, in a cohort of elite athletes. The probiotic strain Lactobacillus helveticus Lafti® L10 was previously reported to have inherent immunological enhancing properties. Namely, supplementation with L. helveticus Lafti® L10 reduced the duration of respiratory infection, increased the CD4+/CD8+ (T helper/T suppressor) cell ratio and enhanced mucosal and humoral immunity in a cohort of elite athletes ( Michalickova et al., 2016 , 2017). Methods

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Effects of Fluid Ingestion on Brain-Derived Neurotrophic Factor and Cognition During Exercise in the Heat

factor-1 (IGF-1) ( Mattson et al., 2007 ). IGF-1 and 5-HT play an important role in the expression of neurotrophic factors such as the brain-derived neurotrophic factor (BDNF) ( Carro et al., 2000 ; Mattson et al., 2004 ). This was evident after the artificial injection of IGF-1 into the peripheral blood vessel, which increased the expression of BDNF in the hippocampus of the brain after exercise ( Carro et al., 2000 ), and 5-HT was crucially involved, along with noradrenaline, in the regulatory mechanism that governed BDNF expression in the brain ( Mattson et al

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