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Earnest Oghenesuvwe Erhirhie, Chibueze Peter Ihekwereme and Emmanuel Emeka Ilodigwe

testing. Toxicol in Vitro 41 : 245–259. Hartung T, McBride M. (2011). Food for thought. on mapping the human toxome. ALTEX 28 : 83–93. Hartung T, Daston G. (2009). FORUM Are In Vitro Tests Suitable for Regulatory Use? Toxicol Sci 111 (2): 233–237. ICCVAM (2006). Test Method Evaluation Report – In Vitro Ocular Toxicity Test Methods for Identifying Ocular Severe Irritants and Corrosives. Inter-agency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the

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Yan-hui Chen, Heng-hui Zhang, Yan Wang, Xing-wang Xie, Ran Fei, Xue-yan Wang, Lai Wei and Hong-song Chen

References 1. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-1061. 2. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-336. 3. Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 2007;8:457-462. 4. Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature

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Georgiana Emilia Grigore, Iuliu C. Ivanov, Mihaela Zlei, Angela Dăscălescu, Roxana Popescu, Tudor Petreuș and Eugen Carasevici

Pathol. 2013 Feb;26(2):182-94. 11. Han T, Abdel-Motal UM, Chang D-K, Sui J, Muvaffak A, Campbell J, et al. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous t-cell lymphoma. PloS one. 2012;7(9):e44455. DOI: 10.1371/journal. pone.0044455 12. Chang D-K, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, et al. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Molecular Cancer Therapeutics. 2012;11(11):2451-61. DOI: 10.1158/1535-7163.MCT-12

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Hakki Yilmaz, M. Cakmak, B. Ceydilek, C. Demir and A. Aktas

References Ait-Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, Zoll J, Merval R, Esposito B, Cohen JL, Fisson S, Flavell RA, Hansson GK, Klatzmann D, Tedgui A, Mallat Z. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12, 178-180, 2006. Akinci B, Comlekci A, Yener S, Bayraktar F, Demir T, Ozcan MA, Yuksel F, Yesil S. Hashimoto’s thyroiditis, but not treatment of hypothyroidism, is associated with altered TGFbeta1 levels. Arch Med Res 39, 397-401, 2008. Bettini M

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Evelina K. Vetskova, Mariya N. Muhtarova, Toma I. Avramov, Tsvetelina R. Stefanova, Ivan J. Chalakov and Maria H. Nikolova

;72(4):433-52. 4. Blumin JH, Handler EB, Simpson CB, et al. Dysplasia in adults with recurrent respiratory papillomatosis: incidence and risk factors. Ann Otol Rhinol Laryngol 2009;118(7):481-5. 5. Nikolova M, Lelievre JD, Carriere M, et al. Regulatory T cells modulate differentially the maturation and apoptosis of human CD8-T cell subsets. Blood 2009;113(19):4556-65. 6. Lohr J, Knoechel B, Caretto D, et al. Balance of Th1 and Th17 effector and peripheral regulatory T cells. Microbes Infect 2009;11(5):589-93. 7. Damyanov C, Terziev

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Jovana Vojvodic, Goran Mihajlovic, Ana Andonov, Milos Markovic, Jelena Djordjevic and Petar Vojvodic

, Xiao B, Qiu W, Yang L, Hu B, Tian X et al. Altered expression of CD4(+)CD25(+) regulatory T cells and its 5-HT(1a) receptor in patients with major depression disorder. J. Affect. Disord. 2010;124:68–75. 62. Bartrop RW, Luckhurst E, Lazarus L, Kiloh LG, Penny R. Depressed lymphocyte function after bereavement. Lancet 1977;1:834–36. 63. Eilat E, Mendlovic S, Doron A, Zakuth V, Spirer Z. Increased apoptosis in patients with major depression: a preliminary study. J. Immunol. 1999; 163: 533–34. 64. Baniyash M. Chronic inflammation, immunosuppression and

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Milica Borovcanin, Ivan Jovanovic, Slavica Djukic Dejanovic, Gordana Radosavljevic, Nebojsa Arsenijevic and Miodrag L. Lukic

Psychiatry. 2003; 4(3): 119-23. 11. Korn T, Anderson AC, Bettelli E, Oukka M. The dynamics of effector T cells and Foxp3+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis. J Neuroimmunol. 2007; 191(1-2): 51-60. 12. Abbas A, Lichtman AH, Pillai S. Cellular and Molecular Immunology, 6th Edition, Saunders, Elsevier, Philadelphia, USA, 2007. 13. Fort MM, Cheung J, Yen D, Li J, Zurawski SM, Lo S, Menon S, Clifford T, Hunte B, Lesley R, Muchamuel T, Hurst SD, Zurawski G, Leach MW, Gorman DM

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Katarzyna Piórkowska, Joanna Nowak, Katarzyna Połtowicz2 and Katarzyna Ropka-Molik

.P. (2009). MicroRNAs: target recognition and regulatory functions. Cell, 136: 215–233. Bertrand E., Chartrand P., Schaefer M., Shenoy S.M., Singer R.H., Long R.M. (1998). Localization of ASH1mRNA particles in living yeast. Mol. Cell., 2: 437–445. Chang T.H., Huang H.Y., Hsu J.B., Weng S.L., Horng J.T., Huang H.D. (2013). An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs. BMC Bioinformatics, 14 Suppl 2: S4. Chatterjee S., Pal J.K. (2009). Role of 5’- and 3’-untranslated regions of mRNAs in

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Bozhidar Hadzhiev and Mariana Murdjeva

-term natural history of Crohn's disease. World J Gastroenterol 2009;15(11):1315-18. Braegger CP, MacDonald TT. Immune mechanism in chronic inflammatory bowel disease. Ann Allergy 1994;72:135-41. Bell SJ, Williams AB, AB Wisel Pilkinson AB, et al. The clinical course of fistulating Crohn's disease. Aliment Pharmacol Ther 2003;17:1145-51. Weiner HL. Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect 2001

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K. Reiterová and D. Antolová

): Demonstration of a Specific Echinococcus multilocularis Antigen in the Supernatant of in vitro Maintained Protoscolices. Zentralbl. Bakteriol. Mikrobiol. Hyg. A, 268: 416–423 [4] Bauder, B., Auer, H., Schilcher, F., Gabler, C., Romig, T., Bilger, B., Aspock, H. (1999): Experimental investigation on the B and T cell immune response in primary pelvic echinococcosis. Parasite Immunol., 21: 409–421. DOI: 10.1046/j.1365-3024.1999.00241.x [5] Borecka, A., Gawor, J., Malczewska, M