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two genes when combined have a better prediction of glioblastoma survival than IDH 1 or MGMT independently, with IDH1mt/MGMTmet having the longest survival rate and IDH1wt/MGMTunmet with the lowest survival rate.[ 46 ] CSCs have shown to elevate the levels of MGMT expression. The ability of CSCs to survive in hypoxic regions makes it virtually impossible for traditional chemotherapies to reach the cells that are crucial for tumor survival and progression.[ 29 , 30 , 47 , 48 ] With increased drug delivery to GBM tissue because of the EPR effect, liposomal NPs have