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E, Skotnicki P, Moskal J, Ambicka A, Harazin-Lechowska A, Wasilewska A, Vogelgesang M, Dyczek S. Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis. Pol J Pathol. 2009;60:98-104, quiz 105. 13. Pepper T, Falla L, Brennan PA. Soft tissue giant cell tumour of low malignant potential arising in the masseter-a rare entity in the head and neck. Br J Oral Maxillofac Surg. 2010;48:149-51. 14. Wieneke JA, Gannon FH, Heffner DK, Thompson LD. Giant cell tumor of the larynx: A

study was to investigate several cases of giant cell tumor of bone (TCG), chondroblastoma and aneurysmal bone cyst (ABC) by immunohistochemistry (IHC) with a panel of markers: p63, S-100, CD68, CD56, DOG1, Galectin-1, D2-40, CD34, CD45 and ki-67, some of which proved to be specifi c for a certain entity. Material and methods. The cases were retrospectively selected from cases processed in our facility where the surgical excision material was histopathologically analyzed in optical microscopy using the usual staining hematoxylin and eosin. The immunohistochemistry

. Material and method. The study included a group of 28 patients, of whom 20 had pelvic limb tumor formation. Malignant bone tumors were present in 18 patients and benign tumors in 10 patients. The most commonly encountered was osteosarcoma in 12 patients, Ewing sarcoma in 4 patients and giant cell tumor in 3 patients. Patient follow-up was conducted within 4 years (with an average of 3-5 years). Results. 5 of our patients developed pulmonary metastases 8 months after surgery and, for 4 of the patients, pulmonary determinations were extirpated without subsequent

. Distribution of the CD68 macrophage/myeloid associated antigen. Int Immunol. 1990;2:973-80. 13. Yamana K, Kinoshita T, Nakano R, Morimatsu M, Nakashima T. Anaplastic giant cell tumor with mucinous cystadenocarcinoma of the ovary. Acta Pathol Jpn. 1984;34:399–402. 14. Matsuta M, Matsuta M, Kagabu T. Ovarian serous adenocarcinoma with anaplastic areas containing osteoclast-like multinucleated giant cells. International Journal of Clinical Oncology. 2000;5: 280-3. 15. L orentzen M. Giant cell tumor of the ovary. Virchows Arch A Pathol Anat Histol. 1980;388:113–22. 16. Young RH

References 1. Turcotte RE. Giant cell tumor of bone. Orthop Clin North Am. 2006; 37(1):35–51. 2. Klenke FM, Wenger DE, Inwards CY, Rose PS, Sim FH. Giant cell tumor of bone: risk factors for recurrence. Clin Orthop Relat Res. 2011; 469(2):591–9. 3. McGrath PJ. Giant-cell tumour of bone: an analysis of fifty-two cases. J Bone Joint Surg Br. 1972; 54(2):216–29. 4. Bertoni F, Present D, Sudanese A, Baldini N, Bacchini P, Campanacci M. Giant-cell tumor of bone with pulmonary metastases. Six case reports and a review of the literature. Clin Orthop Relat Res. 1988; 237

, Kanda S, Mori S, Goto M, Mizuno A, Okabe H, Nakamura T. Imaging features of maxillary osteoblastoma and its malignant transformation. Skeletal Radiol. 1994; 23:509-12. 5. E ckardt JJ, Ivins JC, Perry HO, Unni KK. Osteosarcoma arising in heterotopic ossification of dermatomyositis: Case report and review of the literature. Cancer. 1981; 48:1256-61. 6. Brien EW, Mirra JM, Kessler S, Suen M, Ho JK, Yang WT. Benign giant cell tumor of bone with osteosarcomatous transformation (“dedifferentiated” primary malignant GCT): Report of two cases. Skeletal Radiol. 1997; 26

elastin accumulation in the skin of the Bushke-Ollendorff syndrome. J Invest Dermatol. 1981; 76:284-7. 11. Mindell ER, Northup CS, Douglas HO. Osteosarcoma associated with osteopoikilosis: case report. Am J Bone Joint Surg. 1978; 60(3):406-8. 12. Ayling RM, Evans PEL. Giant cell tumor in a patient with osteopoikilosis. Acta orthop Scand.1988; 59:74-76. 13. Grimer RJ, Davies AM, Starkie CM, Sneath RS. Chondrosarcoma in a patient with osteopoikilosis. Rev Chir Orthop. 1989;116:225-30.

deficits [ 15 ]. Somatic mutations in the H3F3 gene were reported in pediatric glioblastoma [ 16 ] and in giant cell tumors of the bone [ 17 ]. Furthermore, it was recently suggested that the pathogenic mechanism of germline histone mutations is distinct from that of the published cancer-associated somatic histone mutations, and may converge on control of cell proliferation [ 18 ]. In our patient, we identified a heterozygous de novo missense variant in the H3F3A gene (NM_002107.4: c. 185 T>G), which is absent from the gnomAD and from the Slovenian Genome databases

References 1. Jaffe HL, Lichtenstein L. Benign chondroblastoma of bone: a reinterpretation of the so-called calcifying or chondromatous giant cell tumor. Am J Pathol, 1942;18:969-991. 2. Salzer M, Salzer-Kuntschik M, Kretschmer G. Das benign Chondroblastm. Arch Orthop Unfallchir, 1968;64:229-244. 3. Unni KK. Benign chondroblastoma. In: Unni KK, editor. Dahlin’s bone tumors: general aspects and data on 11,087 cases. Philadelphia, PA: Lippincott-Raven; 1996. p. 47-57. 4. Bertoni F, Unni KK, Beabout JW, Harner SG, Dahlin DC. Chondroblastoma of the skull and

REFERENCES 1. Popescu I., Ciuce C. (edit.), Sarafoleanu C. (coord.) - Tratat de Chirurgie. Vol 1. ORL şi Chirurgie Cervico-Faciala. Editura Academiei Romane, Bucuresti, 2012;pp.166-171. 2. Fu Y.S., Perzin K.H. - Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. II. Osseous and fibro-osseous lesions, including osteoma, fibrous dysplasia, ossifying fibroma, osteoblastoma, giant cell tumor, and osteosarcoma. Cancer, 1974;33(5):1289-1305. 3. Lund V.J., Stammberger H., Nicolai P., et al. - European position paper