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Acute cadmium exposure augments MMP-9 secretion and disturbs MMP-9/TIMP-1 balance

, Huang S. Cadmium activates the mitogen activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free Radic Biol Med. 2008; 45:1035-44. 25. Galan A, Garcia-Bermejo ML, Troyano A, Vilaboa NE, De Blas E, Kazanietz MG, et al. Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium induced apoptosis in human promonocytic cells. J Biol Chem. 2000; 275:11418-24. 26. Hyun JS, Satsu H, Shimizu M. Cadmium induces interleukin-8

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Immunotherapeutic efficacy of a Lactobacillus casei lysate as an adjuvant combined with a heated-4T1 mammary carcinoma cell lysate in a murine model of breast cancer

-cell lysate alone. However, with the exception of IL-2, no significant changes in cytokine levels were found after immunization with the L. casei lysate alone. L. casei can induce apoptosis in a colorectal cancer cells in vitro [ 3 ]. In vivo the antitumor effects of L. casei on colorectal cancer are mediated by modulation of regulatory T-cells towards a Th 17 -biased immune response [ 31 ]. These findings are consistent with the increased secretion of IL-17 seen following immunization with the combined vaccine in the present study. The antitumor efficacy of

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Grape seed proanthocyanidin extract ameliorates albuminuria and renal sclerosis in experimental diabetic nephropathy rats

, Numakami K, Saruta T, Itoh H. Glucose loading induces DNA fragmentation in rat proximal tubular cells. Metabolism. 1996; 45: 1348-53. 30. Ortiz A, Ziyadeh FN, Neilson EG. Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys. J Investig Med. 1997; 45:50-6. 31. Lee EY, Lee MY, Hong SW, Chung CH, Hong SY. Blockade of oxidative stress by vitamin C ameliorates albuminuria and renal sclerosis in experimental diabetic rats. Yonsi Med J. 2007; 48

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The biology and clinical potential of circulating tumor cells

immunosuppressive cells (regulatory T cells - Tregs) and myeloid-derived suppressor cells (MDSCs), reduction of immune recognition by down-regulation of antigen processing machinery affecting the major histocompatibility complex (MHC) I pathway, release of immune suppressive mediators (cytokines such as TGFβ, vascular endothelial growth factor [VEGF] and expression of immunoregulatory molecules such as indoleamine-pyrrole 2,3-dioxygenase [IDO], programmed cell death protein 1 [PD-1] / programmed death ligand 1 [PD-L1], T cell Ig domain and mucin domain 3 [Tim-3] / galectin-9

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Expression of p63, TTF–1 and Maspin in Non-Small Cell Lung Carcinoma and Their Effect on the Prognosis and Differential Diagnosis / Küçük Hücreli Dışı Akciğer Karsinomunda p63, TTF-1 ve Maspin Ekspresyonu - Prognoz ve Ayırıcı Tanı Üzerine Etkileri

-Ellis Z, Kondo S, Margaryan NV, Seftor RE, Wheaton WW, Amir S, Pins MR, Schutte BC, Hendrix MJ. Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: Identification of a novel serpin partnership. J Biol Chem. 2005; 280:34210-7. 48. Nakagawa M, Katakura H, Adachi M, Takenaka K, Yanagihara K, Otake Y, Wada H, Tanaka F. Maspin expression and its clinical significance in non-small cell lung cancer. Ann Surg Oncol. 2006;13:1517-23. 49. Hirai K, Koizumi K, Haraguchi S, Hirata T, Mikami I, Fukushima M

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The effect of antimicrobials on verocytotoxin bacteriophage transduction under bovine rumen fluid and broth conditions

treatments), a bacterial regulatory genetic repair mechanism is triggered (also referred to as the SOS response), which is located in a part of the genome that contains the phage genes encoding the lytic phase ( Kimmitt et al ., 2000 ; Janion, 2001 ; Schmidt, 2001 ). Once activated, hundreds of bacteriophages are produced, which are then released into the environment when the bacterial cell lyses ( Kohler et al ., 2000 ; Colon et al ., 2016 ). These phage particles are then free to infect other E . coli , resulting in the transfer of the vtx genes and the

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Distribution of non-allelic histone H1 subtypes in five avian species

References Ajiro K., Borun T.W., Solter D. (1981). Quantitative changes in the expression of histone H1 and H2Bsubtypes and their relationship to the differentiation of mouse embryonal carcinoma cells. Dev. Biol., 86: 206-211. Bhan S., May W., Warren S.L., Sittman D.B. (2008). Global gene expression analysis reveals specific and redundant roles for H1 variants, H1c and H10, in gene expression regulation. Gene, 414: 10-18. Catez F., Ueda T., Bustin M. (2006). Determinants of histone H1 mobility and chromatin

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Assessment of selected exercise-induced CD3+ cell subsets and cell death parameters among soccer players

+ and CD8 + T-cells as compared to participants with lower VO 2 max values. Our study showed that increases in naïve Th (CD4 + ) cells took place in recovery only at the period 1 (the beginning of the competition round), while naïve Tc (CD8 + ) cells increased in recovery in both periods (compared to post-exercise values). This may suggest that exhaustive effort performed at the end of the competition round did not induce regulatory pathways related to Th-cells. On the other hand, it also might suggest that cumulative effects of intense physical activity during the

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Modulation of TLR2 and TLR4 in macrophages following Trichinella spiralis infection

References A ranzamendi , C., de B ruin , A., K uiper , R., B oog , C.J., van E den , W., R utten , V., P inelli , E. (2013): Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infection. Clin. Exp. Allergy , 43(1): 103 – 115. DOI: 10.1111/cea.12042 A ranzamendi , C., F ransen , F., L angelaar , M., F ranssen , F., van der L ey , P., van P utten , J.P., R utten , V., P inelli , E. (2012): Trichinella spiralis -secreted products modulate DC functionality and expand regulatory T cells

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Podocytes and Proteinuric Kidney Disease

(Bethesda) 2009; 24: 88-96. 13. Abbate M Zoja C, Morigi M, et al. Transforming growth factor-beta1 is upregulated by podocytes in response to excess intraglomerular passage of proteins. A central pathway in progressive glomerulosclerosis. Am J Path 2002; 161: 2179. 14. Benzing T. Signaling at the slit diaphragm. J Am Soc Nephrol 2004; 15: 1382-1391. 15. Lasagni L, Romagnani P. Glomerular epithelial stem cells, the good, the bad, and the ugly. J Am Soc Nephrol 2010; 21: 1612-1619. 16. Welsh GI, Saleem MA. The podocyte cytoskeleton-key to a functioning

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