Search Results

101 - 110 of 112 items :

Clear All
Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity

-aspartate-angiotensin-I and angiotensin IV improve glucose tolerance and insulin signalling in diet-induced hyperglycaemic mice. Biochem Pharmacol 82, 1198–1208, 2011. Wu CH, Mohammadmoradi S, Thompson J, Su W, Gong M, Nguyen G, Yiannikouris F. Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice. Hypertension 68, 213–219, 2016. Yamahara N, Nomura S, Suzuki T, Itakura A, Ito M, Okamoto T, Tsujimoto M, Nakazato H, Mizutani S. Placental leucine aminopeptidase/oxytocinase in maternal serum and placenta during

Open access
The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease

acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study, Aliment. Pharmacol. Ther. 23 (2006) 1143-1151; DOI: 10.1111/j.1365-2036.2006.02885.x. 39. L. Li, L. Chen, X. Lin, Y. Xu, J. Ren, J. Fu and Y. Qiu, Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats, J. Pharmacol. Sci. 127 (2015) 244-250; DOI: 10.1016/j.jphs.2014.12.001. 40. N. Zhang, Y. Lu, X. Shen, Y. Bao, J. Cheng, L. Chen, B. Li and Q. Zhang, Fenofibrate treatment

Open access
The Two Faces of Galectin-3: Roles in Various Pathological Conditions

of galectin expression in lean and obese mice: Evidence for regulatory function. Obesity (Silver Spring), 21, 310-319. 40. Butscheid M, Hauptvogel P, Fritz P, Klotz U, Alscher D. (2007). Hepatic expression of Galectin-3 and RAGE in patients with liver disease. J Clin Pathol, 60, 415–418. 41. Jeftic I, Jovicic N, Pantic J, Arsenijevic N, Lukic ML, Pejnovic N. (2015). Galectin-3 Ablation Enhances Liver Steatosis, but Attenuates Inflammation and IL-33-Dependent Fibrosis in Obesogenic Mouse Model of Nonalcoholic Steatohepatitis. Mol Med, 21, 453

Open access
Liver stiffness in chronic hepatitis C virus infection

: Diagnostic performance compared to digital morphometric analysis of liver biopsy in chronic hepatitis C . J Viral Hepat 2018; 25 :335-43. 16. CONTI F., SERRA C., VUKOTIC R., FIORINI E., FELICANI C., MAZZOTTA E., et al. Accuracy of elastography point quantification and steatosis influence on assessing liver fibrosis in patients with chronic hepatitis C . Liver Int 2017; 37 :187-95. 17. BOTA S, SPOREA I, PECK-RADOSAVLJEVIC M, SIRLI R, TANAKA H, IIJIMA H, et al. The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force

Open access
Classical galactosemia in a Thai infant: case report and review of the literature

not specific and lacked of usual morphologic changes, especially microvesicular and macrovesicular steatosis, which have been described in galactosemia [ 13 , 14 ]. Therefore, many potential causes of neonatal hepatitis, including viral infection and metabolic disorders were excluded by investigations. The appropriate treatment for an infant with galactosemia is to (1) eliminate any lactose-containing formula and breast feeding, and begin a formula such as a soy-based formula that contains no lactose as soon as possible, (2) monitor for signs of sepsis, and (3

Open access
Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family

, 191-196, 2004. Ma X, Xu L, Wang S, Cui B, Li X, Xu J, Ning G. Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis. J Hepatol 55, 445-452, 2011. Mackinnon JA, Gallastegui N, Osguthorpe DJ, Hagler AT, Estebanez-Perpina E. Allosteric mechanisms of nuclear receptors: insights from computational simulations. Mol Cell Endocrinol 393, 75-82, 2014. Madak-Erdogan Z, Katzenellenbogen BS. Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin

Open access
Accuracy of noninvasive scoring systems to assess advanced liver fibrosis in Thai patients with nonalcoholic fatty liver disease

biopsy using standard procedures with ultrasonography guidance. Data of all patients were recorded, including demographic data, anthropometric data and biochemical tests on the day of liver biopsy or within 2 weeks of the procedure. All patients were followed-up with the results of liver histological findings within the following 2 weeks. We used the histological findings of liver fibrosis as the criterion standard or index diagnosis. Definition The diagnosis of NAFLD was based on the following criteria: (1) liver biopsy showing steatosis in at least 5% of

Open access
Importance of studying the levels of hepcidin and vitamin D in Egyptian children with chronic hepatitis C

stores upregulate hepcidin expression, while anemia, hypoxia, and oxidative stress downregulate it. [ 4 , 5 ] Hepcidin is recognized as a biomarker for systemic inflammatory states because of upregulation by inflammatory cytokines. [ 3 , 4 , 5 , 6 ] Patients with chronic liver disease (CLD) usually have iron overload, especially hepatitis C virus (HCV), steatosis, and cirrhotic liver; this iron produces free oxygen radicals with harmful effects on various organs. This consensus pay attention to studying the overall iron homeostasis and the regulatory mechanisms

Open access
Nitric oxide products are not associated with metabolic syndrome

without MetS (n=58) and a group with MetS (n=51). Exclusion criteria for all potential participants were: hsCRP >10 mg/L, acute inflammatory disease, diabetes mellitus, liver diseases other than steatosis, kidney diseases, malignant diseases, gout, ethanol consumption >20 g/day, pregnancy, as well as unwillingness to participate in the study. The Ethical Committee of the Primary Health Care Center in Podgorica, Montenegro approved the study protocol. All the volunteers provided signed informed consent, and the research was carried out in compliance with the

Open access
Pleiotropic effects of niacin: Current possibilities for its clinical use

. L. Kashyap and V. S. Kamanna, Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease, Am. J. Physiol. Gastrointest. Liver Physiol. 306 (2014) G320-G327; DOI: 10.1152/ajpgi.00181.2013. 88. M. Hara, M. Kurano, K. Tsuneyama, K. Kikuchi, A. Takai, T. Matsushima and K. Tsukamoto, Nicotinic acid prevents and restores steatohepatitis together with amelioration of postprandial dyslipidemia, Arterioscler. Thromb. Vasc. Biol. 34 (2014) A601. American Heart Association (AHA

Open access