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Determination of kaempferol in extracts from Lilium candidum L. Liliaceae by means of liquid chromatography

quercetin, kaempferol and ( E ) -cinnamic acid in vegetative organs of Schisandra chinensis Baill. by HPLC. J Pharm Biochem Anal. 2001;24:1049-1054. Smělá M. Možnosti stanovenia flavonoidov. Bakalárska práca. Brno: VUT, Chemická fakulta. 2009. Vachálková A, Eisenreichová E, Haladová M, Mučaji P, Jóžová B, Novotný L. Potencial carcinogenic and inhibitory activity of compounds isolated from Lilium candidum L. Neoplasma, 2000;47:313-318. Vitková Z, Grančai D, Haladová M, Herdová P, Cupáková M

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Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells

cancer, Pharmacol. Rev. 52 (2000) 673-751. 6. G. Williamson and C. Manach, Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies, Am. J. Clin. Nutr. 81 (2005) 243S-255S. 7. B. A. Graf, C. Ameho, G. G. Dolnikowski, P. E. Milbury, C. Y. Chen and J. B. Blumberg, Rat gastrointestinal tissues metabolize quercetin, J. Nutr. 136 (2006) 39-44. 8. S. Scholz and G. Williamson, Interactions affecting the bioavailability of dietary polyphenols in vivo, Int. J. Vitam. Nutr.Res. 77 (2007) 224

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Inhibition of glycoxidative modification of proteins by some substances of natural origin

Summary

Introduction: Advanced glycation end-products (AGE) and advanced oxidation protein products (AOPP) are the main products of glycoxidative modification in diabetes. Objective: The aim of this study was to identify the natural substance with the strongest antiglycoxidative properties among dietary supplements or medicines available without prescription in Poland. Methods: Bovine serum albumin (BSA), vitamin C (VC), aminoguanidine (A), quercetin (Q) and green tea (GT) were tested in vitro in comparison to controls in glycation, oxidation and glycoxidation processes. The decreased AGE and AOPP concentrations were measured as markers of these processes. Results: AGE level was reduced by 72% by VC and at least by 43% by all examined substances in the glycation process. AOPP was reduced by 99% by VC and at least by 40% by all examined substances in the oxidation process. Formation of AGE/AOPP was inhibited by 61% by Q and by 97% by A, and at least 49/88% by all examined substances, respectively. This lowering of AGE/AOPP level was statistically significant (p<0.001) for all test substances in comparison to the positive control C(+). Conclusion: All examined substances are able to inhibit glycative, oxidative and glycoxidative modification of proteins in different degrees depending on their concentration.

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Biometric and phytochemical variability of roseroot (Rhodiola rosea L.) from field cultivation

Summary

Roseroot (Rhodiola rosea L.) is an adaptogenic plant, widely used in the traditional medicine of Scandinavia, Russia, China and Mongolia. The aim of the study was to determine the biometric and phytochemical co-variability of this species under field cultivation in western Poland (Plewiska near Poznań). The plant material originated from four-year-old cultivation established twice by rhizome division in autumn 2007 and 2008. In the study, 46 individuals (23 plants in 2011 and in 2012) were used. The biometric analysis included measurements of the basic characteristics of plants related to the size (luxuriance) of clumps, shoots, leaves and rhizomes with roots (raw material). The amounts of total polyphenols (expressed as gallic acid), tannins (expressed as pyrogallol) and flavonoids (expressed as quercetin) were determined spectrophotometrically. The obtained results showed high variation of Rh. rosea, especially in the level of flavonoids (0.01-0.20% DM) and in the weight of raw material (113-1156 g FM/plant). There were observed correlations between the phytochemical (flavonoid and total phenolic content) and biometric (water content, leaf number, shoot and clump size) features.

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Memory Effects Of Aronia Melanocarpa Fruit Juice In A Passive Avoidance Test In Rats

Agric Food Chem 1992;40:1591-8. 12. Gozzani IL, Izquierdo I. Possible peripheral adrenergic and central dopaminergic infl uences in memory consolidation. Psychopharmacology 1976;49:109-11. 13. Tota S, Awasthi H, Kamat PK, et al. Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood fl ow and impairment of memory in mice. Behav Brain Res 2010;209(1):73-9. 14. Valcheva-Kuzmanova S, Blagović B, Valić S. Electron spin resonance measurement of radical scavenging activity of

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New biological findings of ethanol and chloroform extracts of fungi Suillellus rubrosanguineus and Tylopilus felleus

. (2008). Cytotoxic activity of alkaloids isolated from Stephania rotunda in vitro, cytotoxic activity of cepharanthine. Phytother Res 23 (4): 587–590. Danihelova M, Veverka M, Sturdik E, Jantova S. (2013). Antioxidant action and cytotoxicity on HeLa and NIH-3T3 cells of new quercetin derivatives. Inter-discip Toxicol 6 (4): 209–216. Furr M, Mahlberg P G. (1981). Histochemical analyses of laticifers and glandular trichomes in Cannabis sativa . J Nat Prod 44 (2): 153–159. Grzybek J, Zgorniak-Nowosielska I, Kasprowicz A, Zawilinska B

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Protective effect of aronia melanocarpa fruit juice in a model of cisplatin-induced cytotoxicity in vitro

1983;65(1-2):55-63. 7. Konstantinov SM, Eibl H, Berger MR. BCR-ABL infl uences the antileukaemic effi cacy of alkylphosphocholines. Br J Haematol 1999;107(2):365-80. 8. Sanchez-Gonzalez PD, Lopez-Hernandez FJ, Perez- Barriocanal F, et al. Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity. Nephrol Dial Transplant 2011;26(11):3484-95. 9. Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and

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The effect of short-term and long-term application of fisetin on experimentally induced airway hyperreactivity

-1090. [10] O’Byrne PM, Inman MD. Airway Hyperresponsiveness. Chest Journal. 2003; 123: 411-416. [11] Tanaka T, Takahashi R. Flavonoids and asthma. Nutrients. 2013; 5: 2128-2143. [12] Weng Z, Zhang B, Asadi S, et al. Quercetin is more effective than cromolyn in blocking human mast cellcytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoSOne. 2012; 7: 33805.

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Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract

small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Br J Nutr   91 : 841-847. Baynes JW. (1991). Role of oxidative stress in development of complications in diabetes. Diabetes   40 : 405-12. Review. Baynes JW, Thorpe SR. (1999). Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes   48 : 1-9. Review. Beaulieu LP, Harris CS, Saleem A, Cuerrier A, Haddad PS, Martineau LC, Bennett SA, Arnason JT. (2010

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Oleuropein and rutin protect against 6-OHDA-induced neurotoxicity in PC12 cells through modulation of mitochondrial function and unfolded protein response

M, Ataee R. (2016). Polyphenolic Antioxidants and Neuronal Regeneration. Basic Clin Neurosci 7: 81-90. Bali EB, Ergin V, Rackova L, Bayraktar O, Kucukboyaci N, Karasu C. (2014). Olive leaf extracts protect cardiomyocytes against 4-hydroxynonenal-induced toxicity in vitro: comparison with oleuropein, hydroxytyrosol, and quercetin. Planta Med 80: 984-92. Barbaro B, Toietta G, Maggio R, Arciello M, Tarocchi M, Galli A, Balsano C. (2014). Eff ects of the olive-derived polyphenol oleuropein on human health. Int J Mol Sci 15: 18508

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