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Ye Tian, Han Deng, Lei Han, Sijun Hu and Xingshun Qi

studies also suggested its expression in liver fibrosis. In qRT-PCR analyses performed by Mogler and colleagues[ 21 ], a weak expression of CD248/endosialin was restricted to hepatic stellate cells and liver sinusoidal endothelial cells in healthy adult murine, but CD248/endosialin expression was not observed in Kupffer cells or hepatocytes. Similarly, a weak expression of CD248/endosialin was restricted to hepatic stellate cells in healthy adult human livers, but CD248/endosialin expression was not observed in hepatocytes. Therefore, CD248/endosialin might be a

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Roberta Klobučar, Roko Žaja, Damjan Franjević, Anamaria Brozović and Tvrtko Smital

, Sauerborn Klobučar R, Smital T. Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line. Aquat Toxicol 2007;81:365-76. Žaja R, Munić V, Sauerborn Klobučar R, Ambriović-Ristov A, Smital T. Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol 2008;90:322-32. Cai S-Y, Soroka CJ, Ballatory N, Boyer JL. Molecular characterization of a multidrug

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Md. Aktar, Dwaipayan Sengupta, Swarnali Purkait, Madhumita Ganguly and M. Paramasivam

prochloraz and nonylphenol diethoxylate on hepatic biotransformation enzymes in trout: a comparative in vitro/in vivo -assessment using cultured hepatocytes. Aquat Toxicol   53 (3/4): 215-228 Vinggaard AM, Hass U, Dalgaard M, Andersen HR, Bonefeld-Jørgensen E, Christiansen S, Laier P, Poulsen ME. (2006). Prochloraz: an imidazole fungicide with multiple mechanisms of action. Int J Androl   29 (1): 186-92.

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Andra-Iulia Suceveanu, Laura Mazilu, Doina Catrinoiu, Adrian-Paul Suceveanu, Felix Voinea and Irinel-Raluca Parepa

altered circadian rhythm. Am J Gastroenterol 88: 1744-1748, 1993. 18. Price JA, Kovach SJ, Johnson T et al . Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma. Hepatology 36: 1089-1097, 2002. 19. American Diabetes Association . Diagnosis and classification of diabetes mellitus. Diabetes Care 33[Suppl 1]: S62-S69, 2010. 20. Adams LA, Feldstein AE . Nonalcoholic steatohepatitis: risk factors and diagnosis. Expert Rev Gastroenterol Hepatol 4: 623-635, 2010

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Elina G. Manzhalii, Valentyna O. Moyseyenko, Tetyana M. Falalyeyeva, Olena I. Tsyryuk, Vitaliy E. Kondratiuk and Taras D. Nykula

electron transport chain of rat hepatocytes under different steatosis. Research Journal of Pharmaceutical, Biological and Chemical Sciences . 2016;7(4):752-5. 12. Kondro M., Kobyliak N, Virchenko O, Falalyeyeva T, Beregova T, Bodnar P. Multiprobiotic therapy from childhood prevents the development of nonalcoholic fatty liver disease in adult monosodium glutamate-induced obese rats. Curr Issues Pharm. Med. Sci. 2014;2(4):243-5. 13. Baykova IE, Nikitin IG. [Drug liver]. Ross. Med. Zhurn . 2009;1. Article in Russian 14. Buyeverov AO, Yeshanu VS

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Wanvisa Udomsinprasert, Sittisak Honsawek, Wilai Anomasiri, Voranush Chongsrisawat, Paisarn Vejchapipat and Yong Poovorawan

? Eur J Gastroenterol Hepatol. 2003; 15:447. 5. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem. 1996; 271:10697-703. 6. Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab. 2002; 13:84-9. 7. Shimizu A, Takamura T, Matsuzawa N, Nakamura S, Nabemoto S, Takeshita Y, et al. Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line. Metabolism

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Dan-ying Cheng, Xiao-mei Wang, Wei-ni Ou and Hui-chun Xing

;99:1381-1385. 12. Tafazoli S, Mashregi M, O′Brien PJ. Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model. Toxicol Appl Pharmacol 2008;229(1):94-101. 13. Chen CM, Chang B, Zhang D, Xiang GQ, He XH, Wang BY. Etiology and injury types of drug-induced liver injury in shenyang. Shi Jie Hua Ren Xiao Hua Za Zhi (Chin) 2008;16:2525-2528. 14. Danan G. Causality assessment of drug-induced liver injury. J Hepatol 1988;7:132-136. 15. Huang YS, Su WJ, Huang YH, Chen CY, Chang FY, Lin HC, et al. Genetic

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Syed S. Haque

References 1. Adamson GM, Billings RE. Cytokine toxicity and induction of NO synthase activity in cultured mouse hepatocytes. Toxicol Appl Pharmacol.1993;119: 100-107. 2. Granger D L, Jr. Hibbs JB, Perfect JR, Durack DT. Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. J Clin Invest. 1998;81:1129-1136. 3. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992;6: 3051- 3064. 4. Palmer RMJ, Ferrige AG, Moncada S. Nitric

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Mohaddese Mahboubi, Atefeh Mahboubi and Nastaran Kazempour

properties of phenolic acids against hydroperoxide-induced oxidative stress in cultured rat and human hepatocytes. Chem. Listy. 1998; 52(1): 8-10. 19. Askun T, Tumen G, Satil F, Ates M. Characterization of the phenolic composition and antimicrobial activities of Turkish medicinal plants. Pharm. Biol. 2009; 47(7):563-571.

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Dong-Gi Lee, Ik Soon Jang, Kyeong Eun Yang, So-Jung Yoon, Sujeong Baek, Joo Yong Lee, Tatsuro Suzuki, Keun-Yook Chung, Sun-Hee Woo and Jong-Soon Choi

–6455; DOI: 10.1021/jf034543e. 3. J. M. Kawa, C. G. Taylor and R. Przlybylski, Buckwheat concentrate reduces serum glucose in streptozotocin – diabetic rats, J. Agr. Food Chem . 51 (2003) 7287–7291; DOI: 10.1021/jf0302153. 4. C.-C. Lee, W.-H. Hsu, S.-R. Shen, Y.-H. Cheng and S. C. Wu, Fagopyrum tataricum (buckwheat) improved high-glucose–induced insulin resistance in mouse hepatocytes and diabetes in fructoserich diet-induced mice, Exp. Diabetes Res . 2012, 375673; DOI: 10.1155/2012/375673. 5. K. H. Egawa, S. Maegawa, K. Shimizu, Y. Morino, M