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Association of overexpressed MYC gene with altered PHACTR3 and E2F4 genes contributes to non-small cell lung carcinoma pathogenesis

, optimize treatments and enable monitoring disease progression and response to therapy. Molecules that regulate cellular processes essential for maintaining malignant phenotype, such as c-Myc oncogene, stand out as promising candidates to serve as molecular markers. This nuclear phosphoprotein functions as transcriptional regulator of multiple genes and controls cell proliferation, induces apoptosis, and regulates stemness, senescence, metabolism and genome stability ( 4 ). Its expression is deregulated in number of human cancers including breast cancer, Burkitt

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Mouse (Mus musculus) embryonic cerebral cortex cell death caused by carbofuran insecticide exposure

carcasses ( 20 ). In 2001, a flower plantation in Ecuador was contaminated by CF. There were some babies born with impaired reflex and motor functions. During their childhood, the effect of CF contamination was brain development dysfunctions, such as poor concentration and memory ( 8 ). CF, a potential environmental xenobiotic, has the ability to cross the blood–brain barrier and to adversely influence brain functions ( 6 ). Like organophosphate, CF ingestion by gavage may cause significant oxidative damage to the cerebral cortex, cerebellum, and brain stem. Cerebral

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Early postnatal hypothalamic-pituitary-adrenal axis activity and reduced insulin sensitivity in adult rats

from murine embryonic stem cells in vitro. Stem Cells Dev 27, 898–909, 2018. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 359, 61–73, 2008. Hellerstrom C, Swenne I. Functional maturation and proliferation of fetal pancreatic β-cells. Diabetes 40, 89–93, 1991. Hill DJ, Strutt B, Arany E, Zaina S, Coukell S, Graham CF. Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses developmental apoptosis in the

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Therapy-related myelodysplastic syndrome after successful treatment of acute promyelocytic leukemia: case report and literature review


In the 2016 revision of the World Health Organization classification the term therapy-related myeloid neoplasia (t-MN) defines a subgroup of acute myeloid leukemia (AML) comprising patients who develop myelodysplastic syndrome (MDS-t) or acute myeloid leukemia (AML-t) after treatment with cytotoxic and/or radiation therapy for various malignancies or autoimmune disorders. We report the case of a 36 year old patient with t-MN (t-MDS) after achieving complete remission (CR) of a PML-RARA positive acute promyelocytic leukemia (APL) at 32 months after diagnosis. Initially classified as low risk APL and treated according to the AIDA protocol - induction and 3 consolidation cycles - the patient achieved a complete molecular response in September 2013 and started maintenance therapy. On follow-up PML-RARA transcript remained negative. In January 2016 leukopenia and thrombocytopenia developed and a peripheral blood smear revealed hypogranular and agranular neutrophils. Immunophenotyping in the bone marrow aspirate identified undifferentiated blast cells that did not express cytoplasmic myeloperoxidase. The cytogenetic study showed normal karyotype. The molecular biology tests not identified PMLRARA transcript. A diagnosis of t-MDS (AREB-2 - WHO 2008) was established. Treatment of AML was started with 2 “3+7” regimens and 1 MEC cycle. Two months from diagnosis, while in CR, an allogeneic HSCT from an unrelated HLA compatible donor was performed after myeloablative regimen. An unfavorable clinical evolution was followed by death on day 9 after transplantation. The occurrence of t-MNs during CR of APL represents a particular problem in terms of follow-up and differential diagnosis of relapse and constitutes a dramatic complication for a disease with a favorable prognosis.

This work was supported by the grants PN 41-087 /PN2-099 from the Romanian Ministry of Research and Technology

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Performance and Genetic Parameters of Somatic and Zygotic Progenies of Coastal Douglas-fir at 71/2-Years across Washington and Oregon, USA

References ADAMS, W. T. and D. G. JOYCE (1990): Comparison of selection methods for improving volume growth in young coastal Douglas-fir. Silvae Genet. 39: 219-226. BALTUNIS, B. S., D. A. HUBER, T. L. WHITE, B. GOLDFARB and H. E. STELZER (2005): Genetic effects of rooting loblolly pine stem cuttings from a partial diallel mating design. Can. J. For. Res. 35: 1098-1108. BENOWICZ, A., S. C. GROSSNICKLE and Y. A. EL-KASSABY (2002): Field assessment of Douglas-fir somatic and zygotic seedlings with respect to gas

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Acquisition and Expansion of Adult Rat Bone Marrow Multipotent Mesenchymal Stromal Cells

REFERENCES 1. Animal Protection Act of Slovakia No. 15/1995, part 39 (In Slovak), 1250—1255. 2. Caplan, A. I., Dennis, J. E., 2006: Mesenchymal stem cells as trophic mediators. J. Cell. Biochem. , 98, 1076—1084. 3. Chesier, S. H., Kalani, M. Y. S., Lim, M., Ailles, L., Huhn, S. L., Weissman, I. L., 2009: A neurosurgeon’s guide to stem cells, cancer stem cells, and brain tumor stem cells. Neurosurgery , 65, 237—250. 4. Čížková, D., Rosocha, J., Vanický, I., Jergová, S., Čížek, M., 2006: Transplants of human mesenchymal stem cells

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Growth Performance and Heritability Estimation of Acacia crassicarpa in a Progeny Trial in eastern Thailand

References Arnold RJ and E Cuevad (2003) Genetic variation in early growth, stem straightness and survival in A. crassicarpa, A. mangium and Eucalyptus urophylla in Nukindon Province, Philippines. Journal of Tropical Forest Sciences 15 (2): 332-351. Awang K, NA Shukor and AL Senin (1995) Two-year performance of Acacia crassicarpa provenances at Serdang, Malaysia. Pertanika J. Trop. Agric. Sci. 18(3): 177-181. Holland BJ, WE Nyquist and CT Cervantes-Martinez (2003) Estimating and interpreting heritability for plant breeding [online] pp. 9-112. In

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Early Selection of Douglas-Fir across South Central Coastal Oregon, USA

References ADAMS, W. T., S. N. AITKEN, D. G. JOYCE, G. T. HOWE and J. VARGAS-HERNANDEZ (2001): Evaluating efficacy of early testing for stem growth in coastal Douglas-fir. Silvae Genet. 50: 167-175. ADAMS, W. T. and D. G. JOYCE (1990): Comparison of selection methods for improving volume growth in young coastal Douglas-fir. Silvae Genet. 39: 219-226. BRUCE, D. and D. J. DEMARS (1974): Volume equations for second-growth Douglas-fir. USDA, Forest Service Research Note PNW-239, USDA, PNWFRES: Portland, Oregon

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Genetic Variation and Correlations between Growth and Wood Density of Calycophyllum spruceanum at an Early Age in the Peruvian Amazon

References ARNOLD, R. J., I. G. JOHNSON and J. V. OWEN (2004): Genetic variation in growth, stem straightness and wood properties of Eucalyptus dunnii trials in northern New South Wales. Forest Genetics 11: 1-12. ASTM (1997): Standard test methods for specific gravity of wood and wood-base materials. ASTM D2395-93. In: Annual book of ASTM Standards 4.10. pp. 348-355. American Society for Testing and Materials, Philadelphia. BAUCH, J. and O. DÜNISCH (2000): Comparison of growth dynamics and wood characteristics

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Phenotypic Selection of Calycophyllum spruceanum on Farms in the Peruvian Amazon: Evaluating a Low-Intensity Selection Strategy

rate, stem straightness, and foliar mineral concentration in Vochysia guatemalensis. Canadian Journal of Forest Research 27: 1103-1109. CORNELIUS, J., C. R. CLEMENT, J. C. WEBER, C. SOTELOMONTES, J. VAN LEEUWEN, L. J. UGARTE-GUERRA and L. ARÉVALO-LÓPEZ (2006): The trade-off between genetic gain and conservation in a participatory improvement programme: the case of peach palm (Bactris gasipaes Kunth). Forest, Trees and Livelihoods 16: 17-34. DAWSON, I. K., A. LENGKEEK, J. C. WEBER and R. JAMNADASS (2008): Managing genetic variation in

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