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Elastographic and morphological testicular changes in hypothyroidism – an experimental study

processing. Section 4 μm thick were stained with haematoxylin and eosin (HE) and examined under an Olympus BX63 light microscope (Olympus Corporation, Japan). All morphological studies were made using a blank test method, and slides were decoded when the results were obtained. The slides were also analysed microscopically for evaluation of spermatogenesis according to the Johnsen score (JS) ( 15 ). Spermatogenesis was classified using a scale from 1 to 10 where these scores correspond to these criteria: score 10 – full spermatogenesis; score 9 – slightly impaired

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The association between the APACHE-II scores and age groups for predicting mortality in an intensive care unit: a retrospective study

Med 2012; 38: 1654-1661. doi: 10.1007/s00134-012-2629-6 4. Sacanella E, Pérez-Castejón JM, Nicolás JM, Masanés F, Navarro M, Castro P, et al. Functional status and quality of life 12 months after discharge from a medical ICU in healthy elderly patients: a prospective observational study. Crit Care 2011; 15: R105. doi: 10.1186/cc10121 5. Leong IY, Tai DY. Is increasing age associated with mortality in the critically ill elderly. Singapore Med J 2002; 43: 33-36 6. Huang Y, Chen J, Zhong S, Yuan J. Role of APACHE-II scoring system in the prediction of

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Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a


Introduction: Depression and cognitive impairment are the most frequent mental disorders in multiple sclerosis (MS) and represent an important cause of morbidity and mortality. The aim of the study was to analyse the main determinants of depression in multiple sclerosis.

Materials and methods: Thirty-two patients with relapsing remitting multiple sclerosis (RRMS), treated with Interferon Beta 1a, without relapses and corticosteroid treatment in the last 30 days, were included in the study. The mean age of the patients was 35.4±9.2 years, M/F ratio 0.33. Depression level was evaluated by the Romanian version of Beck Depression Inventory (BDI) and the cognitive function with Paced Auditory Serial Addition Test 3 (PASAT 3), Symbol Digit Modalities Test (SDMT). The functional status and disability level of the patients were evaluated with Multiple Sclerosis Functional Composite and Expanded Disability Status Scale. In all patients a cerebral MRI with intravenous contrast administration was performed using a 1.5T MRI device.

Results: Twenty-three patients were free of depression (score 1-10), 4 patients presented mild mood disturbance (score 11-16), 3 borderline clinical depression (score 17-20) and 2 moderate depression (score 21-30). The mean BDI score was 8.71±7.16. BDI score correlated significantly with EDSS (R=0.38, p=0.03), PASAT 3 (R=-0.42, p=0.01), SDMT (R=-0.58, p=0.0007), Timed 25-Foot Walk (R=0.43, p=0.01) and 9-Hole Peg Test (R=0.45, p=0.008). From the EDSS functional scores, significant correlations were found with the urinary score (R=0.4, p=0.01) and sensitive score (R=0.49, p=0.004). BDI score correlated significantly with the total number of T2 lesions (R=0.31, p=0.05) while there was no correlation with the number of active lesions.

Conclusions: The main determinants of depression in RRMS patients are the cognitive impairment, the affection of fine hand movements (9-HP), gait impairment (T25FT) and bladder and sensitive dysfunction.

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Male smokers with HLA-B27 positivity, SI joints inflammation have more radiological damages and higher prevalence of AS while females have higher BASDAI scores: observations from cluster analyses of a group of SpA patients

-assessment questionnaires–BASDAI, BASFI, and Bath Ankylosing Spondylitis Global Index (BASGI) (10) –to calculate the Ankylosing Spondylitis Disease Activity Score (ASDAS) (11) . Spinal mobility was measured according to the Bath Ankylosing Spondylitis Metrology Index (BASMI) (12) . Radiographs of cervical and lumbosacral spine were used to determine the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) (13) and radiological sacroiliitis based on the Modified New York (MNY) criteria (14) : grade 0, normal; 1, doubtful; 2, obvious; 3, fusion. Bilateral sacroiliitis grade 2

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Management of patients with liver cirrhosis and invasive bladder cancer: A case-series

considered a major risk factor carrying an increased morbidity and mortality in cirrhotic patients undergoing any kind of surgery, as they can often decompensate because of both anesthesia and surgery. [ 12 , 13 , 14 , 15 ] Diverse scores and indexes have been used for predicting the outcome of patients preoperatively, among which the American Society of Anesthesiologists (ASA) score and the age-adjusted Charlson Comorbidity Index (aaCCI) are the most validated for the pre- and perioperative evaluation. [ 14 , 15 , 16 ] However, in cirrhotic patients, the Child

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Neutrophil-to-lymphocyte ratio relation to sepsis severity scores and inflammatory biomarkers in patients with community-acquired pneumonia: A case series

Introduction Sepsis and the related multiple organ failure remains a worldwide problem leading to high morbidity and mortality rates. The currently available organ failure scoring systems, such as the Sequential Organ Failure Assessment (SOFA), the Acute Physiology and Chronic Health Evaluation II (APACHE II) and the Simplified Acute Physiology II (SAPS II) scores are useful in the assessment of organ dysfunction over time and have been established as clinically useful indexes of severity and prognosis. The neutrophil-to-lymphocyte ratio (NLR) calculated

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Simultaneous pure laparoscopic resection of primary colorectal cancer and synchronous liver metastases: a single institution experience with propensity score matching analysis

study was to compare the surgical and oncological outcomes of patients undergoing simultaneous resection of primary colorectal cancer and SCLM by laparoscopic or open surgery using propensity score matching. Patients and methods Patient selection and study design All patients with SCLM were discussed by the multidisciplinary team. Treatment decisions were based on location and complexity of resection of the primary tumor, extent of liver resection, liver function and physical condition of the patients. The policy of the institution is not to combine a

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Correlations Between Severity of Coronary Lesions and Epicardial Fat Volume in Patients with Coronary Artery Disease – a Multislice CT-based Study


Background: Epicardial fat has been recently identified as a major player in the development of the atherosclerotic process.

Study aim: The aim of this study was to correlate the epicardial fat volume (EFV), determined by Multisclice CT, and the severity of the coronary lesions, expressed by the Coronary Calcium Score (CCS) and Syntax Score (SxS) in patients with established coronary artery disease (CAD).

Material and methods: One-hundred-twenty-six patients underwent Multisclice 64 CT assessment of coronary lesions and epicardial fat quantification. Calculation of CCS was performed on all the three coronary vessels and was followed by determination of SxS according to guidelines. The patients were divided into 2 groups: Group 1 – patients with CCS >400 (n = 26), and Group 2 — patients with CaS <400 (n = 100).

Results: The mean age of the study population was 65.32 years for Group 1 and 54 years for Group 2 (p <0.0001). However, patients >65 years of age had a high CCS in a more significant extent than younger patients (50% in Group 1 vs. 17% in Group 2, p = 0.0115). Female gender was recorded in 48% of cases in Group 2 and in 19% of cases in Group 1 (p = 0.008). Several factors were identified in a higher extent in the group with high CCS as compared with the group with low CCS, such as the presence of significant stenosis (>50%) of the left anterior descending artery (LAD) (46% vs. 9%, p <0.0001), the presence of multi-vessel coronary disease (50% vs. 5%, p <0.0001) and a high SxS, above 23 (23% vs. 4%, p = 0.006). The epicardial fat volume was 117.81 ± 40.4 ml (95% CI: 97.98–138.2 ml) in Group 2 and 89.77 ± 37.7 ml (95% CI: 80.4–101.5 ml) in Group 1 (p = 0.0033).

Conclusions: Epicardial fat volume could represent a new imaging-derived biomarker, useful for classification of the severity of coronary artery disease, increased values of EFV being associated with other biomarkers of disease severity, such as calcium score.

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Gait and Computerized Dynamic Posturography (CDP) Aspects in Early Progressive Supranuclear Palsy (PSP) - A Case Report


BACKGROUND: Posture and gait instability may cause of morbidity in individuals with progressive supranuclear palsy (PSP).

OBJECTIVE: To quantitatively measure balance control by using computerized dynamic posturography (CDP) and to assess gait analysis in early PSP.

CASE REPORT: She was evaluated for Berge balance scale, Functional Independence Measure (FIM) and postural stability using CDP device in early PSP with still able to walk or stand unassisted. Also, Gait analysis was conducted using an 8 M-camera Vicon 612 data capturing system set. Berge balance scale improved from 41/56 to 48/56. The score of FIM improved from 71/126 points to 95/126 points in early PSP. In CDP analysis, there was a decrease of composite equilibrium score (38 %). There was an increase of composite equilibrium score (59%) after three months of treatment. In gait analysis, there was no difference of gait parameters after three months of treatment in early PSP.

CONCLUSIONS: Both CDP and gait analysis are important quantitative tools in the assessment of posture and gait instability as well as allow for early disclosure of the failure of the postural control system in early PSP.

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Evaluating the Direct and Indirect Effects of SF-36 Domains Score on Two Main Factors in Diabetic Patients with Path Analysis: Health-Related Quality of Life Study

depression in diabetes (EDID) research consortium. Curr Diabetes Rew 5(2): 112-119, 2009 20. Glasgow RE, Ruggiero L, Eakin EG, Dryfoos J, Chobanian L. Quality of life and associated characteristics in a large national sample of adults with diabetes. Diabetes Care 20(4): 562-567, 1997 21. Ware Jr JE. How to score the revised MOS short-form health scale (SF-36®). New Engl Med Centr Hosp 10: 17-18, 1988 22. Ware Jr JE Sherbourne CD . The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Med Care 30 (6): 473

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