M Šeruga, J Makuc, M Završnik, I Cilenšek, R Ekart and D Petrovič
Type 2 diabetesmellitus (T2DM) is a multifactorial chronic metabolic disease characterized by post-prandial hyperglycemia that causes long-term macrovascular or microvascular complications. Microvascular complications are diabetic nephropathy (DN), neuropathy and diabetic retinopathy (DR) [ 1 , 2 ]. Diabetesmellitus (DM) is the most common cause of chronic kidney disease and end-stage renal disease [ 1 , 2 ]. In the pathogenesis of DN several environmental, genetic, and epigenetic factors are involved in complex interactions [ 3 - 5 ].
3. The BARI Investigators. Seven-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status. J Am Coll Cardiol2000; 35:1122-9. http://dx.doi.org/10.1016/S0735-1097(00)00533-7
4. Kang X, Berman DS, Lewin HC, Cohen I, Friedman JD, Germano G, et al. Incremental prognostic value of myocardial perfusion single photon emission computed tomography in patients with diabetesmellitus. Am Heart J 1999;138:1025-32 http://dx.doi.org/10.1016/S0002
identified if P<0.05; P a : P-value for healthy pregnant woman group; P b : P-value for Se-supplemented women with GDM group; P c : P-value for the 03 groups; GDM: Gestational diabetesmellitus, BMI: Body mass index, SBP: Systolic blood pressure; DBP: Diastolic blood pressure.
Before Se supplementation, pregnant women with GDM had significantly lower plasma Se level associated with fasting hyperglycemia, and were more vulnerable to oxidative stress increase, whose levels of plasma and erythrocyte MDA and PC were significantly higher, and levels of all studied
alban , P. A., D onath , M. Y. (2002): Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest. , 110: 851 – 860. DOI: 10.1172/jci15318
N agakubo , D., S hirai , M., N akamura , Y., K aji , N., A risato , C., W atanabe , S., T akasugi , A., A sai , F. (2014): Prophylactic effects of the glucagon-like Peptide-1 analog liraglutide on hyperglycemia in a rat model of type 2 diabetesmellitus associated with chronic pancreatitis and obesity. Comp. Med. , 64: 121 – 127
O kamoto , M., T aira , K
Adela-Gabriela Firănescu, Adina Popa, Maria-Magdalena Sandu, Diana Cristina Protasiewicz, Simona Georgiana Popa and Maria Moţa
1. Morton R. Phthisiologia: or a treatise of consumptions. London: Smith and Walford , 1694.
2. Rajalakshmi S, Veluchamy G. Yugi's pramegam and diabetesmellitus: an analogue. Bull Indian Inst Hist Med Hyderabad 29: 83–87, 1999.
3. Harries AD, Satyanarayana S, Kumar AMV et al. Epidemiology and interaction of diabetesmellitus and tuberculosis and challenges for care: a review. Public Health Action 3 [Suppl 1]: S3-S9, 2013.
4. Dooley KE, Chaisson RE. Tuberculosis and diabetesmellitus: convergence of two epidemics
Mihaela Vladu, Diana Clenciu, Mihaela Bîcu and Maria Mofa
Background and Aims: Diabetes mellitus (DM) is a chronic disease which can evolve towards devastating micro and macro-vascular complications. Chronic kidney disease (CKD) is a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease (CVD) and premature death. The aim of our study was to evaluate the prognosis in patients with DM and CKD, depending on estimated glomerular filtration rate (eGFR) and albuminuria, according to the classification of Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (KDIGO) from 2013 Materials and Methods: The study was epidemiological, transversal, non interventional type, with 600 subjects unselected patients divided into three subgroups: 200 patients with T1DM, 200 patients with T2DM and 200 age matched subjects without DM. The recorded data have been analyzed using the Statistic Package for Social Sciences (SPSS), the 17.00 software (IBM Corporation, Armonk, NY, United States of America). Results:. We found a statistically significant difference among the three study groups (p < 0.0001) regarding the prognosis of CKD. Conclusions: DM represents an important risk factor for the appearance of CKD but also a negative prognosis factor for the patients with CKD.
Background and Aims Diabetes mellitus (DM) represents a worldwide health problem and a major epidemic during the past decades. The exact number of people with diabetes in Romania is unknown. The aim of this paper was to determine the number of subjects registered with diabetes in Romania. Material and Method: The Romanian Society of Diabetes, Nutrition and Metabolic Diseases (RSDNMD) asked the representatives in charge with DM in each county about the total number of subjects registered with DM, the number of subjects with newly diagnosed DM in 2011 and their treatment (insulin or oral drugs). Results: There are 803,489 persons registered with DM, with a national prevalence of 4.21%. The lowest prevalence was observed in Ilfov (0.9%) and the highest prevalence (7.83%) in Bucharest. A total of 125,574 diabetics (15.62%) are treated only with insulin while 81,910 (10.19%) with combined insulin and oral medication. In 2011 have been registered 68.294 new cases of diabetes, with an incidence of 358.63/100,000 persons. The lowest incidence was 91.15 in Giurgiu county and the highest incidence was 718.94 in Arad county. Conclusions: There are large and unexplained differences between counties for both diabetes prevalence and incidence. Consequently, RSDNMD decided to start a national epidemiological study (PREDATORR) that will be carried out in 2013.
F. Casoinic, D. Sampelean, Anca D. Buzoianu, N. Hancu and Dorina Baston
screen-detected diabetes? Diabet Med. 2008; 25(12):1433-1439.
21. WU YT, CHIEN CL, WANG SY, YANG WS, WU YW. Gender differences in myocardial perfusion defect in asymptomatic postmenopausal women and men with and without diabetesmellitus. J Women Health. 2013; 22(5):439-444.
22. GAMBINO R, MUSSO G, CASSADER M. Redox balance in the pathogenesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities. Antioxid Redox Signal. 2011; 15(5):1325-1365.
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Larisa Renata Pantea-Roșan, Otilia Anca Ţica, Mădălina Moisi, Vlad Alin Pantea, Ovidiu Ţica, Cosmin Vesa, Katalin Babeș, Mihaela Popoviciu and Mircea Ioachim Popescu
The prognosis of STEMI patients experiencing the no-reflow phenomenon is unfavorable both in the short- and long-term compared to patients who do not develop this pathology, and it is even worse as other cardiovascular risk factors There is a correlation between the no-reflow phenomenon and diabetes mellitus type II and obesity and this conditions represent stong predictors of mortality.
S, Bugliani M, D'Aleo V, Occhipinti M, Boggi U, Marselli L, Masini M. Goals of treatment for type 2 diabetes: beta-cell preservation for glycemic control. Diabet Care 2009; 32: 178-83. (PMC free article) [PubMed]
11. National Diabetes Statistics 2007 Fact Sheet. National Institute of Diabetes and Digestive and Kidney Diseases; Bethesda, DC, USA: 2007.
12. Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H.Heritability of type II (non-insulin-dependent) diabetesmellitus and abnormal glucose tolerance-a populationbased twin study