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References 1. Den Boer M.L., Harms D.O., Pieters R., Kazemier K.M., Gobel U., Körholz D., Graubner U., Haas R.J., Jorch N., Spaar H.J., Kaspers G.J., Kamps W.A., Van der Does-Van den Berg A., Van Wering E.R., Veerman A.J., Janka-Schaub G.E.: Patient stratification based on prednisolone-vincristineasparaginase resistance profiles in children with acute lymphoblastic leukemia. J Clin Oncol 2003, 21, 262-3268. 2. Escherich G., Tröger A., Göbel U., Graubner U., Pekrun A., Jorch N., Kaspers G., Zimmermann M., zur Stadt U., Kazemier K., Pieters R., Den Boer M

cell growth by the anti-tumor drug Ukrain. Drugs Exp Clin Res 1992, 18 , 1-4. 11. Jagiełło-Wojtowicz E., Kleinrok Z., Urbanska E.M.: Ukrain (NSC631570) in experimental and clinical studies: a review. Drugs Exp Clin Res 1998, 24 , 213-219. 12. Kang M.H., Harutyunyan N., Hall C.P., Papa R.A., Lock R.B.: Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma. Br J Haematol 2009, 145 , 389-393. 13. Kimura E., Nishimura K., Sakata K., Opa S., Kashiwagi K., Igarashi K.: Methotrexate

development [ 25 ]. It is also a critical regulator of hematopoietic and vascular development and is misexpressed in the majority of patients with T-cell acute lymphoblastic leukemia (ALL) [ 26 ]. Tumor-specific activation of the TAL1 gene occurs in ~25% of patients with T-cell ALL [ 27 ]. Thus, TAL1 might be closely connected with the development and progression of AML. RIF metric was used to identify critical TFs from gene-expression data. The top 5 ranked TFs in experiment 4 were TP53, HOXA5, HLF, MECOM, and NR3C1. Moreover, TP53 was one of the core genes in the PPI

HIV B-cell epitopes Autoimmun. Rev 2008 7 291 296 [53] Polito, A., Polimeno, R., Kanduc, D., Peptide sharing between Parvovirus B19 and DNA methylating/histone modifying enzymes: a potential link to childhood acute lymphoblastic leukemia, Int. J. Pediatr. Child Health, 2017, 5, 29-39. Polito A. Polimeno R. Kanduc D. Peptide sharing between Parvovirus B19 and DNA methylating/histone modifying enzymes: a potential link to childhood acute lymphoblastic leukemia Int. J. Pediatr. Child Health 2017 5 29 39 [54] Kanduc, D., Epstein-Barr virus, immunodeficiency, and cancer