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Assessment of Inflammatory Status Based on Total Blood Count and Its Relationship to Cardiovascular Diseases


Background: Inflammation seems to be the most important trigger for atherosclerosis. Lower extremity artery disease (LEAD) and hypertension (HTN) are the most important atherosclerotic diseases. Total blood count-derived neutrophil-lymphocyte ratio (NLR) and red cell distribution width (RDW) have been proposed as inflammatory biomarkers in cardiovascular diseases. The aim of this study was to assess the correlation with LEAD and HTN.

Material and methods: In total, 134 subjects were included in the study, divided into 2 groups as follows: group 1 – patients with LEAD and HTN; group 2 – subjects with HTN, without LEAD. Complete blood count (CBC) and lipid profile were determined. To assess peripheral artery disease, the ankle-brachial index (ABI) was measured with a handheld Doppler device (BiDop ES100V3 Hadeco®). We compared the inflammatory status between the groups with the use of white blood cell count (WBC), red cell distribution (RDW), and neutrophil-lymphocyte ratio (NLR).

Results: In group 1, there was a significant negative correlation between the ABI and RDW (p = 0.04, r2 = –0.24, 95% CI: 0.4647–0.0013), as well as between the ABI and NLR (p = 0.001, r2 = –0.38, 95% CI: 0.5801–0.1592). In group 2, there was a positive correlation between NLR and total serum cholesterol levels (p = 0.003, 95% CI: 0.1274–0.5472, r2 = 0.12), as well as between NLR and triglyceride levels (p = 0.002, 95% CI: 0.1387–0.5552, r2 = 0.13).

Conclusion: NLR and RDW could represent first-line investigations in patients with cardiovascular disease due their cost efficiency. They can also play a role in triaging patients with atherosclerotic disease, monitoring treatment response and prognosis of the disease.

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The Whitening Efficiency on Colored Teeth
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Perioperative ketamine for acute analgesia and beyond

.0b013e3181bdc8a0 15. Martinez V, Cymerman A, Ben Ammar S, Fiaud JF, Rapon C, Poindessous F, et al. The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomized, double-blind, controlled study. Anaesthesia 2014; 69: 46-52. doi: 10.1111/anae.12495 16. Adam F, Chauvin M, Du Manoir B, Langlois M, Sessler DI, Fletcher D. Small-dose ketamine infusion improves postoperative analgesia and rehabilitation after total knee arthroplasty. Anesth Analg 2005; 100: 475-480. doi: 10.1213/01.ANE.0000142117.82241.DC 17

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Thrombus Aspiration, from “Heart to Soul”

.1111/j.1525-1594.2009.00770.x. 22. Yan Li, Rafiroiu D, Iancu A, et al. CFD analysis study on the impact of the coronary anatomy on the efficiency of the coronary thrombectomy: the effect of bend angles. Meditech 2011, IFMBE Proceedings 36:306-309. 23. Sajjad Soleimani-Amiri. A study of coronary clot removal by means of aspiration actheters. PhD thesis, Politecnico di Milano, 2011 24. Bhindi R, Kajander OA, Jolly SS, et al. Culprit lesion thrombus burden after manual thrombectomy or percutaneous coronary intervention-alone in ST-segment elevation

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Postanaesthetic shivering – from pathophysiology to prevention

Anesthesiol 2017;17: 1. doi: 10.1186/s12871-016-0295-x 45. Zhou C, Zhu Y, Liu Z, Ruan L. 5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis. J Int Med Res 2016; 44: 1174-1181. doi: 10.1177/0300060516668776 46. He K, Zhao H, Zhou HC. Efficiency and safety of ondansetron in preventing postanaesthesia shivering. Ann R Coll Surg Engl 2016; 98: 358-366. doi: 10.1308/rcsann.2016.0152 47. Li M, Hu X, Tan Y, Yang B, Li K, Tang Z . Meta-analysis of randomized controlled trials on the efficacy

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Monitoring Acute Myocardial Infarction Complicated with Cardiogenic Shock — from the Emergency Room to Coronary Care Units

;8:20-23. 25. Tucker JF, Collins RA, Anderson AJ, Hauser J, Kalas J, Apple FS. Early diagnostic efficiency of cardiac troponin I and Troponin T for acute myocardial infarction. Acad Emerg Med. 1997;4:13-21. 26. Vaughan L. Biomarkers in acute medicine. Medicine. 2013;41:136-141. doi: . 27. Tanindi A, Cemri M. Troponin elevation in conditions other than acute coronary syndromes. Vasc Health Risk Manag. 2011;7:597-603. doi:10.2147/VHRM.S24509. 28. Gunnewiek JM, Van

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In-stent Flow Hemodynamics and the Risk of STent Failure Following Bioresorbable Vascular ScAFFolds Implantation – the STAFF Study


Background: Myocardial revascularization procedures have undergone important developments over the last decades, which led to a major shift in current clinical practice and therapeutic guidelines across the world. Bare metal and drug-eluting stents present several limitations, all centered on the concept of disturbed coronary hemodynamics after implantation, which can be surpassed by bioresorbable vascular scaffolds (BVS). BVSs are fourth-generation stents used in coronary revascularization procedures, but despite all the promising initial results published on their efficiency, several clinical trials have reported unsatisfactory results, and the main explanation was accredited to improper implantation method. Shear stress is a central element of intravascular homeostasis; it controls vascular remodeling, as well as the development, progression, and destabilization of atheromatous plaques. This study aims to assess the role of in-stent flow hemodynamics (evaluated by computational determination of shear stress via coronary CT imaging) in predicting the clinical evolution following BVS implantation.

Material and methods: This case-control observational study will include patients with BVSs implanted at least 12 months prior to randomization. Each patient will undergo a complete evaluation of the demographic and clinical characteristics, cardiovascular risk factors, and imaging acquisitions via coronary CT angiography, based on which the endothelial shear stress will be calculated before and after BVS implantation. Post-processing of CT imaging data will evaluate the shear stress and the composition of the coronary plaques along the entire coronary tree. The primary endpoint will be the major adverse cardiovascular events (MACE) in patients with altered vs. non-altered BVS-related shear stress, and the secondary endpoints will comprise evaluating the rate of progression of stent resorption and progression of shear stress alteration.

Conclusions: The findings of the STAFF study can be extremely useful in clinical practice for providing an answer to a key question that is still under debate: why do BVSs fail and how can we prevent this?.

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Stem Cell Mobilization and Harvesting Failure in Case of Heavily Pretreated Patients

. Pozotrigo M, Adel N, Landau L, et al. Factors impacting stem cell mobilization failure rate and efficiency in multiple myeloma in the area of novel therapies: experience at Memorial Sloan Kattering Cancer Center. Bone Marrow Transplantation . 2013;48:1033-1039. 9. Worel N, Rosskopf K, Neumeister P, et al. Plerixafor and granulocyte-colony-stimulating factor (G-CSF) in patients with lymphoma and multiple myeloma previously failing mobilization with G-CSF with or without chemotherapy for autologous hematopoietic stem cell mobilization: the Austrian experience on a

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Correlation Between Orthodontic Forces and Root Resorption – a Systematic Review of the Literature

FG, Diedrich PR. Efficiency of a pendulum appliance for molar distalization related to second and third molar eruption stage. Am J Orthod Dentofacial Orthop . 2004;125:8-23. 13. Wahab MA, Dasor R, Senafi M, et al. Crevicular alkaline phosphatase activity and rate of tooth movement of female orthodontic subjects under different continuous force applications. International Journal of Dentistry . 2013;[245818]. 14. McFadden WM, Engstrom C, Engstrom H, Anholm JM. A study of the relationship between incisor intrusion and root shortening. Am J Orthod

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Stem Cell Therapy in Wound Healing

Exp . 2017. doi: 10.3791/54539. 35. Maharlooei MK, Bagheri M, Solhjou Z, et al. Adipose tissue derived mesenchymal stem cell (AD-MSC) promotes skin wound healing in diabetic rats. Diabetes Res Clin Pract . 2011;93:228-234. 36. Cianfarani F, Toietta G, Di Rocco G, et al. Diabetes impairs adipose tissuederived stem cell function and efficiency in promoting wound healing. Wound Repair Regen . 2013;21:543-553. 37. Mesimäki K, Lindroos B, To˝rnwall J, et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J

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