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Impact of g-Load Shift on Temporal Expression Pattern of Apoptosis-linked Proteins in the Rat Mammary Gland

Introduction Cellular proliferation and apoptosis are evolutionary conserved mechanisms vital for coordinating growth at both organ and tissue levels. Critically, the coordinated regulation of cell proliferation and apoptosis is pivotal to preserving organismal homeostasis ( Liebermann et al., 1995 ; Streichan et al., 2014 ). Therefore, any dysregulation in cellular turnover kinetics impacts organ differentiation and function and sequentially predisposes these organs/organ systems to pathology or failure ( Davis and Ryan, 1998 ; Edelblum et al., 2006

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Challenges of ERAU’s First Suborbital Flight Aboard Blue Origin’s New Shepard M7 for the Cell Research Experiment In Microgravity (CRExIM)

launch to December 8, 2017, with a launch window from December 8 to December 11, 2017. On November 26, 2017, the CRExIM team was notified of a change in the launch date to December 11, 2017. This final launch date was given the day of the scrubbed flight, which the team came to know about 3 min before liftoff. Finally, our payload needed to be rearranged to maximize the science collected on December 12, 2017. Had this launch been scrubbed again, it would have left our team with no science data since the in vitro experiment would have reached an apoptosis stage. Not

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Investigation of Murine T-Cells and Cancer Cells under Thermal Stressors and 2D Slow Rotating System Effects as a Testbed for Suborbital Flights

various animal models ( Choi et al., 2018 ), genetically engineered (humanized mice), as a new alternative for testing the effects of cancer immunotherapy and gaining insights about the behaviors of diverse cancers. Besides the simple tests conducted by our team, there are multiple other assays to assess cells viability, such as apoptosis assays, MTT (colorimetric assay for assessing cell metabolic activity), and many others. Failure to do so may result in unfortunate consequences, such as the lost opportunity to gain valuable scientific knowledge. Relevancy to

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