Search Results

You are looking at 1 - 4 of 4 items for :

  • Keyword: blood glucose x
  • Endocrinology, Diabetology x
Clear All Modify Search
Open access

Kateryna Moshenets

Abstract

Background and aims: to develop a prognostic mathematical model for risk of microangiopathy in patients with diabetes mellitus type 1 (T1DM). Materials and methods: 62 T1DM patients were divided into 2 groups according to НвА1с level: group 1 (n=18) with НвА1с ≤ 7.0% and group 2 (n=44) with НвА1с > of 7.0%. HbA1c, Cpeptide, blood creatinine, estimated glomerular filtration rate (eGFR) CKD-EPI, first morning urinary albumin excretion (AU) were determined. Blood glucose levels were conducted by CGMS (Continuous Glucose Monitoring System). All patients were followed for 3 months. Rank correlation method was used. Results: We established the direct correlation between HbA1c the AU level ρ=0.29 (р<0.016) at the beginning and ρ=0.4 (р=0.021) after 3 months. AU level has a direct correlation with blood glucose range, at the beginning ρ=0.51 (р<0.001) and after 3 months ρ=0.48 (р=0.004) visits. We made the mathematical description of this dependence. Each additional unit of blood glucose range is accompanied by increasing an average level AU level by 0.4816 mg/l. Conclusion: our mathematical equation of dependence between AU level and blood glucose range gives the opportunities to predict diabetic kidney disease progression in T1DM patients.

Open access

Nahla Al-Bayyari, Nesreen Saadeh, Raed Hailat and Safaa Al-Zeidaneen

Abstract

Background and aims: Atorvastatin is a member of the drug class known as statins, which used as a lipid-lowering agent. The study aim was to assess the effect of atorvastatin on body weight and blood glucose levels among diabetic and non-diabetic patients.

Material and Methods: A 359 hyperlipidemic Jordanian patients using atorvastatin at least for 1 year were divided into two groups: diabetic (DM) and non-diabetic (NDM). The changes in lipid profile, thyroid function test, blood glucose indices as well as body weight were assessed and compared between both groups.

Results: There was no statistical significant (p > 0.05) difference between means of body weight after treatment among DM (85.74 ± 3.56) and NDM (81.75 ± 1.25) groups. Descriptive statistics and mean comparisons before and after atorvastatin treatment, showed statistical significant (p ≤ 0.05) differences in body weight and total cholesterol among NDM group and in total cholesterol and LDL-Ch among DM group. There was an increase in fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) and a decrease in triglycerides among both groups but the difference was not statistically (p > 0.05) significant.

Conclusions: Atorvastatin may increase body weight, fasting blood glucose and HbA1c for diabetic and non-diabetic patients.

Open access

Bogdan Timar, Viorel Șerban, Alina Lăcătușu, Laura Barna, Florentina Fiera and Adrian Vlad

Abstract

Objectives: Optimal glycemic control is mandatory in diabetic children and adolescents for the prevention of diabetes complications, but it is difficult to be obtained due to a series of factors, including the limited availability of blood glucose self-monitoring tests. The aim of our study was to investigate the relationship between the number of daily self-monitoring tests and quality of glycemic control. Material and method: We enrolled 783 individuals previously diagnosed with Type 1 Diabetes Mellitus and investigated the significance of differences in HbA1c values between groups with distinct number of blood glucose measurements at home for each age group. Results: We found significant improvements of glycemic control with the increase in the number of daily tests, with some particularities among the groups. Conclusions: Among other intrinsic and external factors, blood glucose selfmonitoring has an important role in obtaining a good glycemic control.

Open access

Kamil Asghar Imam, Madiha Sarwar, Usman Wali, Lubna Siddique and Shahida Perveen

Abstract

Objectives: Diabetes mellitus has been linked with specific morphological and metabolic abnormalities of skeletal muscle in a fiber specific manner. Aim: The present study was designed to compare the contractile functions of slow and fast skeletal muscles in streptozotocin (STZ) induced diabetic male and female Sprague Dawley rats. Material and methods: Thirty healthy Sprague Dawley rats (15 male and 15 female) were divided into two groups and studied after four weeks following diabetes induction. The rats in group I (male diabetic; n = 15) and group II (female diabetic; n = 15) were fed on normal pellet diet and water ad libitum and rendered diabetic by single intraperitoneal injection of STZ 65 mg/kg body weight at the start of study (day 1). At the end of four weeks, the contractile parameters of slow soleus and fast extensor digitorum longus (EDL) muscles were recorded by iWorx advanced animal/human physiology data acquisition unit (AHK/214). Results: At the end of four weeks, the weight of isolated soleus and EDL muscles in the male diabetic rats was significantly higher (p < 0.001) as compared to the female diabetic rats. However, no significant difference was found in any of the contractile functions of isolated soleus and EDL muscles when compared between the male and female diabetic rats. Conclusion: No gender differences exist in the contractile functions of slow and fast skeletal muscles in streptozotocin induced diabetic Sprague Dawley rats.