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Open access

V. Sloup, I. Jankovská, I. Langrová, M. Štolcová, S. Sloup, S. Nechybová and P. Peřinková

Abstract

The experiment was conducted on 18 Wistar rats during a six-week period; 12 animals were given zinc lactate (120 mg/rat and week) in feed mixture and 6 control animals were fed a standard mixture for rats (ST-1). Sixteen biochemical parameters were measured from blood (serum) samples: total protein (TP), albumin (ALB), urea (UREA), glucose (GLU), triacylglycerols (TAG), non-esterified fatty acids (NEFA), cholesterol (CHOL), creatinine (CREAT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), uric acid (UA), magnesium (Mg), calcium (Ca), phosphorus (P), and trace elements such as Fe and Zn. When compared to the control group, we found that rats fed zinc lactate had higher concentrations of GLU, UA, UREA, Fe, Mg, Ca, TAG, TP, ALB, and ALP in the blood serum. Contrarily, the concentrations of AST, NEFA, CHOL, CREAT, P, and Zn were higher in the blood serum of control rats. Statistically significant differences between rats fed Zn and the control were found only in the concentrations of GLU, AST, ALP, UA, and P.

Open access

Kateryna Moshenets

Abstract

Background and aims: to develop a prognostic mathematical model for risk of microangiopathy in patients with diabetes mellitus type 1 (T1DM). Materials and methods: 62 T1DM patients were divided into 2 groups according to НвА1с level: group 1 (n=18) with НвА1с ≤ 7.0% and group 2 (n=44) with НвА1с > of 7.0%. HbA1c, Cpeptide, blood creatinine, estimated glomerular filtration rate (eGFR) CKD-EPI, first morning urinary albumin excretion (AU) were determined. Blood glucose levels were conducted by CGMS (Continuous Glucose Monitoring System). All patients were followed for 3 months. Rank correlation method was used. Results: We established the direct correlation between HbA1c the AU level ρ=0.29 (р<0.016) at the beginning and ρ=0.4 (р=0.021) after 3 months. AU level has a direct correlation with blood glucose range, at the beginning ρ=0.51 (р<0.001) and after 3 months ρ=0.48 (р=0.004) visits. We made the mathematical description of this dependence. Each additional unit of blood glucose range is accompanied by increasing an average level AU level by 0.4816 mg/l. Conclusion: our mathematical equation of dependence between AU level and blood glucose range gives the opportunities to predict diabetic kidney disease progression in T1DM patients.

Open access

Nahla Al-Bayyari, Nesreen Saadeh, Raed Hailat and Safaa Al-Zeidaneen

Abstract

Background and aims: Atorvastatin is a member of the drug class known as statins, which used as a lipid-lowering agent. The study aim was to assess the effect of atorvastatin on body weight and blood glucose levels among diabetic and non-diabetic patients.

Material and Methods: A 359 hyperlipidemic Jordanian patients using atorvastatin at least for 1 year were divided into two groups: diabetic (DM) and non-diabetic (NDM). The changes in lipid profile, thyroid function test, blood glucose indices as well as body weight were assessed and compared between both groups.

Results: There was no statistical significant (p > 0.05) difference between means of body weight after treatment among DM (85.74 ± 3.56) and NDM (81.75 ± 1.25) groups. Descriptive statistics and mean comparisons before and after atorvastatin treatment, showed statistical significant (p ≤ 0.05) differences in body weight and total cholesterol among NDM group and in total cholesterol and LDL-Ch among DM group. There was an increase in fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) and a decrease in triglycerides among both groups but the difference was not statistically (p > 0.05) significant.

Conclusions: Atorvastatin may increase body weight, fasting blood glucose and HbA1c for diabetic and non-diabetic patients.

Open access

Bogdan Timar, Viorel Șerban, Alina Lăcătușu, Laura Barna, Florentina Fiera and Adrian Vlad

Abstract

Objectives: Optimal glycemic control is mandatory in diabetic children and adolescents for the prevention of diabetes complications, but it is difficult to be obtained due to a series of factors, including the limited availability of blood glucose self-monitoring tests. The aim of our study was to investigate the relationship between the number of daily self-monitoring tests and quality of glycemic control. Material and method: We enrolled 783 individuals previously diagnosed with Type 1 Diabetes Mellitus and investigated the significance of differences in HbA1c values between groups with distinct number of blood glucose measurements at home for each age group. Results: We found significant improvements of glycemic control with the increase in the number of daily tests, with some particularities among the groups. Conclusions: Among other intrinsic and external factors, blood glucose selfmonitoring has an important role in obtaining a good glycemic control.

Open access

Kamil Asghar Imam, Madiha Sarwar, Usman Wali, Lubna Siddique and Shahida Perveen

Abstract

Objectives: Diabetes mellitus has been linked with specific morphological and metabolic abnormalities of skeletal muscle in a fiber specific manner. Aim: The present study was designed to compare the contractile functions of slow and fast skeletal muscles in streptozotocin (STZ) induced diabetic male and female Sprague Dawley rats. Material and methods: Thirty healthy Sprague Dawley rats (15 male and 15 female) were divided into two groups and studied after four weeks following diabetes induction. The rats in group I (male diabetic; n = 15) and group II (female diabetic; n = 15) were fed on normal pellet diet and water ad libitum and rendered diabetic by single intraperitoneal injection of STZ 65 mg/kg body weight at the start of study (day 1). At the end of four weeks, the contractile parameters of slow soleus and fast extensor digitorum longus (EDL) muscles were recorded by iWorx advanced animal/human physiology data acquisition unit (AHK/214). Results: At the end of four weeks, the weight of isolated soleus and EDL muscles in the male diabetic rats was significantly higher (p < 0.001) as compared to the female diabetic rats. However, no significant difference was found in any of the contractile functions of isolated soleus and EDL muscles when compared between the male and female diabetic rats. Conclusion: No gender differences exist in the contractile functions of slow and fast skeletal muscles in streptozotocin induced diabetic Sprague Dawley rats.

Open access

M. Woźny, P. Brzuzan, M. Gusiatin, E. Jakimiuk, S. Dobosz and H. Kuźmiński

Influence of zearalenone on selected biochemical parameters in juvenile rainbow trout (Oncorhynchus mykiss)

Zearalenone (ZEA) is a mycoestrogen frequently found in food and animal feed materials all over the world. Despite its hydrophobic character, ZEA is also found in surface and ground waters which suggests an environmental risk for aquatic animals. Knowledge concerning mycotoxin-related mechanisms of toxicity is still incomplete, e.g. little is known about the influence of ZEA exposure on fish. The aim of this study was to investigate the effect of ZEA on selected biochemical parameters in juvenile rainbow trout after 24, 72, and 168 h of intraperitoneal exposure (10 mg/kg of body weight). The analysis showed a slight tendency towards prolonged blood clotting time and significant iron deficiency in the liver and ovary of exposed animals. However, no differences in aminotransferase (AlaAT, AspAT) activity or glucose levels in fish plasma was observed. The results of this study suggest that although trout exposed to ZEA did not exhibit any distinct symptoms of liver damage, the mycotoxin tested was able interfere with blood coagulation and iron-storage processes.

Open access

Usman Muhammad Tang, Zainal Abidin Muchlisin, Henni Syawal and Heri Masjudi

Abstract

The objectives of the present study were to analyze the effect of temperature regimes on stress levels and to determine the suitable water temperature for the domestication of tapah, Wallago leeri Bleeker. A completely randomized method was used in this study, and three levels of water temperature were tested, namely, 27, 29, and 31°C, in seven replicates. A total of 500 experimental fish were collected from the Kampar River, Langgam, Riau, Indonesia, and transported to the Aquaculture Laboratory, Riau University. The fish were reared in 21 tanks at stocking densities of 70-100 fish tank−1. The fish were fed rough fish three times a day at 08:00, 12:00, and 21:00 for 30 days. Blood samples were taken on days 1, 14, and 29, which were analyzed for cortisol, glucose, and plasma protein. Growth and survival rates were recorded at the end of the experiment. ANOVA showed that water temperature had a significant effect on the stress condition, growth, and survival rate of tapah. Lower blood glucose, protein, and cortisol plasma levels were recorded in fish acclimatized at 29°C with values of 14.44 mg dL−1, 5.35 g dL−1, and 6.90 mg mL−1, respectively. Additionally, higher growth performance (32.30 g) and survival rates (100%) were also found in fish reared at 29°C. It was concluded that the best water temperature for the domestication of tapah is 29°C.

Open access

Oluwaseun Serah Iyasere, Ikechuckwu Joseph James, Tolulope Julius Williams, James Olamitubo Daramola, Kabir Olumide Lawal, Oyegunle Emmanuel Oke and Emmanuel Iyasere

Abstract

Nineteen West African Dwarf (WAD) goats were used to investigate the physiological and behavioural responses of dams and kids to short-term separation. The dams were naturally mated with bucks and after parturition the kids remained with their respective dams for 5 weeks. Thereafter, the dams were separated from their kids for 10 minutes / week for three weeks (week 5 – 7). Physiological indicators, namely, eye temperature (ET), heart rate (HRT) and blood glucose (GLUC) were taken from each dam, while the ET and HRT were taken from the kids before and after the separation. The behaviours of the dams and kids were recorded during the separation period at the 7th week. Changes (before minus after) in the physiological parameters (ET, HRT and GLU) for the three weeks were analysed using repeated measures ANOVA while the behavioural data were analysed using non parametric test (SPSS statistical package). The ΔGLUC of WAD dams was greater at the 5th than 7th week. At the 5th week also, the ΔET was greater in dams with single kids than those with twins. Litter size did not influence the behaviour of the dams during separation. A significant correlation was established between ΔHRT and urination in dams. Although sex of the kids had no significant effect on both the physiological and behavioural indicators monitored, negative correlations were established between vocalization bouts and escape attempts (r = −0.516, P < 0.01), duration of vocalisation and escape attempts (r = −0.427, P < 0.05). In conclusion, only WAD dams showed physiological responses indicative of stress during the period of separation.