This is the story of the serial killer, Mrs. Gesina Gottfried from Bremen, Germany. She was executed in 1831, being charged and convicted for having murdered at least 16 people, partly from her own family, with arsenic trioxide.
Veera Tepsumethanon, Boonlert Lumlertdacha and Channarong Mitmoonpitak
Background: Rabies is a fatal disease. However, dogs are the principal vehicle for rabies transmission of human. A little information about pre-morbid behavior in rabid dogs could be found in the literature. Objective: Assess the value of history taking in predicting rabies diagnosis in dogs, and identify the percentage of rabies positives by history taking in a prospective study. Materials and methods: Studies were conducted at the Rabies Diagnostic Unit, Queen Saovabha Memorial Institute, Thai Red Cross Society between 2002 and 2008. Historical data were collected prospectively from 153 live rabies suspected dogs on admission to the diagnostic facility. Results: Rabies was found in 14% to 80% of dogs with completed questionnaires except for dogs less than one month old, not sick or sick for more than 10 days. Conclusion: History taking does not help in decision-making for rabies post-exposure prophylaxis of humans.
Irina Franciuc, Cristina Maria Mihai, Alina Martinescu, Loredana Mariana Aftenie and Adina Honcea
The aim of this study was to present the cases with family history of type 1 diabetes in a group of pediatric patients from the Clinic of Pediatrics, Constanta County Hospital, and to analyze the risk for relatives conferred by presence of particular DR genotypes. 8 out of 60 index cases had relatives affected with type 1 diabetes (13.33%). Of these, four had firstdegree relatives affected (6.67%) and were presented here. Although high-risk genotypes were more frequent in the group of familial cases, no association was found between DR genotype and family history of type 1 diabetes when statistical significance was tested (p value 0.119).
Stela Mariana Al Hussein, Hussam Al Hussein, Camil Eugen Vari, Nicoleta Todoran, Hamida Al Hussein, Adriana Ciurba and Maria Titica Dogaru
Objective. This study aimed to evaluate the effects of practices and attitudes towards lifestyle in adolescence as risk or protective factors, for both the acne occurrence and lesions’ severity.
Methods. A cross-sectional study based on a self-reported questionnaire was conducted during 4 months on 148 high school students, aged 16-20 years, in a high school community of Tîrgu Mureș. Acne prevalence and severity, demographic and anthropometric characteristics, the family history of acne vulgaris, smoking behavior and the weekly intake of certain food categories supposed to increase the risk of acne vulgaris were evaluated. Statistical analysis was performed in terms of Odds ratio, Confidence Interval and Chi-square (p<0.05) methods.
Results. In the investigated community, acne prevalence was found of 47.30%, while 78 subjects (control group) had no facial acne lesions. In acne group: 57.1% had family history of acne, 62.9% were smokers, 22.9% were overweight or obese and 84.3% did not receive any dietary information from specialists. 41.4% were not fish consumers, while 74.3% rarely or never were eating fruits and vegetables. Statistically significant differences between the two analyzed groups were found in terms of sweets, carbonated drinks, dietary fat, white bread, fish, fruits and vegetables weekly intake.
Conclusions. Family history, smoking behavior, excessive dietary fat, sweets, carbonated drinks and white bread could be considered as risk factors in acne vulgaris. An increased weekly intake of fish, vegetables and fruits, may have a protective effect in acne development or severity.
Tase Cristina Ramona, Cojocaru Lucia, Rusali Andrei and Suta Cristina
We present the case of a 25 years old patient who was submitted to our unit with a first time acute coronary syndrome. Despite his young age he had multiple cardiovascular risk factors. Although the chest pain was atypical and the electrocardiogram on presentation had unspecific changes, repeated investigations established the diagnosis of anterolateral myocardial infarction. Per primam angioplasty with stent implantation in the proximal segment of left anterior descending artery was performed, with good clinical outcome. Awareness is the key in establishing the diagnosis of myocardial infarction in young patients.
Aleksandar J. Ignjatovski was born in the Smolensk Region, Russia, on 18.03.1875. He graduated from the Faculty of Medicine in St. Petersburg in 1899 where he started specialization in internal medicine and continued in Berlin, Heidelberg, Munich and Paris. In 1905 he was elected assistant professor in St. Petersburg, continued as an associate professor in Odessa in 1908 and a full-time professor in 1912 in Warsaw. During the October Revolution, he was the Head of the Internal Clinic in Rostov, and in 1920 he emigrated to Belgrade. In 1922 he was appointed full professor and Director of the First Internal Clinic at the Faculty of Medicine in Belgrade, which he established, developed and managed until his retirement in 1946. In 1948 he moved to Skopje as a full professor and first Director of the Internal Clinic at the Faculty of Medicine in Skopje. He studied the pathogenesis of arteriosclerosis and first proved it experimentally, and published a paper in 1908, indicating that it was associated with higher blood cholesterol level. He also dealt with immunobiology and infectious diseases, in particular tuberculosis and tetanus. Prof. A. Ignjatovski was an excellent clinician, teacher and scientist, who published over 80 papers. His most important textbooks are “Clinical Semiotics and Symptomatic Therapy”, in two editions, in Russian (1919) and in Serbian (1929-37), and “The Basics of Internal Propedeutics” in three volumes, published in Skopje in 1952, 1954 and 1963. The work of Prof. A. Ignjatovski, as a leading clinician and a great teacher and scientist, is embedded in the development of internal medicine, and medicine in general, in Russia, Serbia and Macedonia. The bright memorial of the founder and first director of the Internal Medicine Clinic and the first Head of the Department of Internal Medicine at the Faculty of Medicine in Skopje has been permanently incorporated in the history of medicine in R. Macedonia. Prof. A. Ignjatovski died on 18.08.1955.
Fodor József (1843–1901) is the founder of Hungarian hygiene who established the second hygiene department and hygiene institute in the world; he was a member of the Hungarian Academy of Sciences. He lived in the era of great microbiological discoveries, and his rich and multidisciplinary work has opened up new directions and approaches in science. For a short period of time he was professor at the newly established university from Cluj (Kolozsvár), later he had important contributions to the Hungarian public health act of 1876. His entire professional career represents a very special model by the messages left behind. He was proposed for Nobel Prize in medical (biological) sciences, but he suddenly died on 20 March 1901.
Bereczki Dániel, Balla Árpád, Pelok Benedek and Szatmári Szabolcs
Pax Corporis is the first book written in Hungarian that presents in detail human diseases, their etiology and treatment. Ferenc Pápai Páriz had completed the manuscript entitled Pax Corporis in 1687, and it was published 3 years later in 1690 in Kolozsvár. Ferenc Pápai Páriz summarized the knowledge he gained during his studies and accumulated during his personal practice. He did not write this book for the professionals but for those poor people who had no access to physician’s care. This was the reason why Pax Corporis was written in Hungarian. Whereas Pápai’s Latin language scripts – for example his doctoral thesis written in Basel – are known to the international scientific community, the Hungarian language Pax Corporis remained unknown for all who were not familiar with the language. For this reason it also remained neglected that in Pax Corporis Ferenc Pápai Páriz had given a detailed description of all four currently acknowledged cardinal signs of Parkinson’s disease – tremor, rigor, bradykinesia and postural instability – and also of other characteristics of the disease 130 years before James Parkinson. The report on the description of the syndrome of Parkinson’s disease in Pax Corporis was presented to the international professional community in 2009. In the current study we evaluated the international recognition of Ferenc Pápai Páriz as one of the first descriptors of all 4 cardinal signs of Parkinson’s disease. We searched scientific citation databases – Web of Science, Scopus, Google Scholar – and also performed general searches on the web. We found that until April 2018 Pápai Páriz has been cited among those who first described the complete motor syndrome of Parkinson’ disease in Pax Corporis, in many countries of the world from New Zealand to Canada, and also in 16 European countries. Citations appeared in dissertations, scientific publications, textbooks, handbooks, professional websites and other documents. Three centuries after his original Hungarian script, Ferenc Pápai Páriz got his international recognition in medical history as one of the first descriptors of the syndrome of Parkinson’s disease.
Andrzej Wrobel, Malgorzata Korzeniowska, Agnieszka Polak, Marcin Szczygiel and Rafal Wrobel
This is one of a series of articles about pharmacists in Lublin district, in the 19th and 20th c. The first recorded owner of the pharmacy in Adamów was Aleksander Biernacki (1851-1897), who passed it onto his son-in-law, Aleksander Rogoziński (1873-1941), and who, in turn, passed it onto his son, Stanisław Rogoziński (1913-1998), married to Tatiana (1918-1998). This family's history is an example of the history of Polish intelligentsia in the second half of 19th c., in the times of the Russian partition, World War I, 1918-1939, World War II and until contemporary times.
Georgi Prisadov, Thomas Landes and Gabriella Kruger
Thoracoscopic Resection of Solitary Pulmonary Nodules in Patients with Previous Malignant Tumors
Round opacities in the lungs found in the course of a neoplastic disorder or during the initial tumor staging are most often regarded as metastases without histological studies to prove their nature. These presumed metastases are, however, very often diagnosed later as benign lesions or primary malignant pulmonary tumors.
Aim: To investigate the histological substrate of solitary pulmonary nodules in patients with a history of neoplastic condition and study the role of video-assisted thoracoscopy in their diagnosing and treatment.
Method: The study included 22 patients with solitary pulmonary nodules and history of previous malignant tumors who underwent video-assisted thoracoscopic surgery at the Clinic of Vascular and Thoracic Surgery, University Hospital Aschersleben, Germany between 01.01.2006 and 31.12.2009. Pulmonary wedge resection was performed and it was followed by histological verification.
Results: A diagnosis of pulmonary metastasis was confirmed in only 8 of the patients (36.4%). In another 8 of them (36.4%) the solitary pulmonary nodule proved to be a primary lung cancer, i.e. a second malignant tumor. The bronchial carcinoma was synchronous with the primary tumor in four of these patients, and metachronous in the rest. In the other 6 patients (27.2%) the lesions proved to be benign.
Conclusions: Not all solitary pulmonary nodules in patients with preceding malignant formations are metastases. In order to define their nature more precisely they should be resected by video-assisted thoracoscopy, if possible. In benign lesions video-assisted thoracoscopic resection is the definitive medical procedure too.